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- Kanoni, Stavroula, et al.
(author)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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In: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Journal article (peer-reviewed)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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- Lucchi, Nicola, 1971-, et al.
(author)
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Market Structure and Innovation Policies in Sweden
- 2017
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In: Innovation Policies in the European News and Media Industry. - Cham : Springer. - 9783319452043 - 9783319452029 ; , s. 191-205
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Book chapter (peer-reviewed)abstract
- The chapter explores the regulatory framework and the types of media innovation policies formulated and implemented in Sweden. In particular, the country's analysis illustrates the evolution and structure of news media markets and media cross-ownership policies in recent years and evaluates how innovation policies stimulate innovative activities in journalism and news media.
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- Mattsson, Niklas, et al.
(author)
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Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease
- 2018
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In: Neurology. - 0028-3878. ; 90:5
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Journal article (peer-reviewed)abstract
- To compare PET imaging of tau pathology with CSF measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance for Alzheimer disease (AD).We compared t-tau and p-tau and 18F-AV-1451 in 30 controls, 14 patients with prodromal AD, and 39 patients with Alzheimer dementia, recruited from the Swedish BioFINDER study. All patients with AD (prodromal and dementia) were screened for amyloid positivity using CSF β-amyloid 42. Retention of 18F-AV-1451 was measured in a priori specified regions, selected for known associations with tau pathology in AD.Retention of 18F-AV-1451 was markedly elevated in Alzheimer dementia and moderately elevated in prodromal AD. CSF t-tau and p-tau was increased to similar levels in both AD dementia and prodromal AD. 18F-AV-1451 had very good diagnostic performance for Alzheimer dementia (area under the receiver operating characteristic curve [AUROC] ∼1.000), and was significantly better than t-tau (0.876), p-tau (0.890), hippocampal volume (0.824), and temporal cortical thickness (0.860). For prodromal AD, there were no significant AUROC differences between CSF tau and 18F-AV-1451 measures (0.836-0.939), but MRI measures had lower AUROCs (0.652-0.769).CSF tau and 18F-AV-1451 have equal performance in early clinical stages of AD, but 18F-AV-1451 is superior in the dementia stage, and exhibits close to perfect diagnostic performance for mild to moderate AD.This study provides Class III evidence that CSF tau and 18F-AV-1451 PET have similar performance in identifying early AD, and that 18F-AV-1451 PET is superior to CSF tau in identifying mild to moderate AD.
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Mediebarometern 2020
- 2021
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Editorial collection (other academic/artistic)abstract
- Mediebarometern är en årlig undersökning av den svenska befolkningens tillgång till, och användning av, olika typer av medier. Undersökningen har genomförts sedan 1979 och det gör Mediebarometern till den äldsta studien i sitt slag i världen. Resultaten i 2020 års undersökning bygger på svar från omkring 6 000 slumpmässigt utvalda personer i åldern 9 till 85 år. Mediebarometern genomförs av Nordicom vid Göteborgs universitet i samverkan med Dagens Nyheter, Göteborgs-Posten, Myndigheten för press, radio och tv, Sveriges Radio, Sveriges Television och Sveriges Utbildningsradio.
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- Ohlsson, Jonas, 1980, et al.
(author)
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A matter of cultural distinction: News consumption in the online media landscape
- 2017
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In: European Journal of Communication. - : SAGE Publications. - 0267-3231 .- 1460-3705. ; 32:2, s. 116-130
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Journal article (peer-reviewed)abstract
- The world of online news is a world where news consumers must make choices among a plethora of different news sources. Previous research points towards a fragmentation of news consumption across the citizenry. However, not enough attention has been paid to class, in particular cultural capital, and how it shapes how groups in society develop preferences for different categories of online news. Drawing upon a representative national survey in Sweden (N=11,108), a country historically known for its egalitarian news consumption, we show that cultural capital engenders patterns of taste and distaste for different online national news providers. This is manifested in that those rich in cultural capital are more inclined to consume ‘quality’ news and to neglect ‘popular’ news. A relative lack of cultural capital is associated with a somewhat reverse pattern. News consumption in the online media landscape is a matter of cultural distinction.
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