SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Oksenberg Jorge R.) ;pers:(Vyse Timothy J.)"

Sökning: WFRF:(Oksenberg Jorge R.) > Vyse Timothy J.

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Langefeld, Carl D., et al. (författare)
  • Transancestral mapping and genetic load in systemic lupus erythematosus
  • 2017
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.
  •  
2.
  • Din, Lennox, et al. (författare)
  • Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes
  • 2019
  • Ingår i: Genetic Epidemiology. - : WILEY. - 0741-0395 .- 1098-2272. ; 43:7, s. 844-863
  • Tidskriftsartikel (refereegranskat)abstract
    • Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p =.0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Vyse, Timothy J. (2)Ta bort avgränsningen
Glimelius, Bengt (1)
Gunnarsson, Iva (1)
Svenungsson, Elisabe ... (1)
Scherbarth, Hugo R (1)
Berbotto, Guillermo ... (1)
visa fler...
García, Mercedes A (1)
Truedsson, Lennart (1)
Alarcón-Riquelme, Ma ... (1)
D'Alfonso, Sandra (1)
Baca, Vicente (1)
Orozco, Lorena (1)
Ortego-Centeno, Norb ... (1)
Pons-Estel, Bernardo ... (1)
Martin, Javier (1)
Adami, Hans Olov (1)
Melbye, Mads (1)
Berndt, Sonja I (1)
Conti, David V (1)
Chanock, Stephen J (1)
Albanes, Demetrius (1)
Travis, Ruth C (1)
Giles, Graham G (1)
Carlsson Almlöf, Jon ... (1)
Rönnblom, Lars (1)
Kelly, Jennifer A. (1)
Kaufman, Kenneth M. (1)
Guthridge, Joel M. (1)
Brown, Elizabeth E. (1)
Ramsey-Goldman, Rosa ... (1)
Reveille, John D. (1)
Vila, Luis M. (1)
Criswell, Lindsey A. (1)
Edberg, Jeffrey C. (1)
Freedman, Barry I. (1)
Gregersen, Peter K. (1)
Gilkeson, Gary S. (1)
Jacob, Chaim O. (1)
James, Judith A. (1)
Kamen, Diane L. (1)
Kimberly, Robert P. (1)
Merrill, Joan T. (1)
Niewold, Timothy B. (1)
Tsao, Betty P. (1)
Langefeld, Carl D. (1)
Harley, John B. (1)
Gaffney, Patrick M. (1)
Vineis, Paolo (1)
Frostegard, Johan (1)
Cervera, Ricard (1)
visa färre...
Lärosäte
Uppsala universitet (2)
Karolinska Institutet (2)
Umeå universitet (1)
Linköpings universitet (1)
Lunds universitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy