| 1. |
- Augustsson, Anna, et al.
(författare)
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The risk of overestimating the risk-metal leaching to groundwater near contaminated glass waste deposits and exposure via drinking water
- 2016
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 566, s. 1420-1431
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates metal contamination patterns and exposure to Sb, As, Ba, Cd and Pb via intake of drinking water in a region in southeastern Sweden where the production of artistic glass has resulted in a large number of contaminated sites. Despite high total concentrations of metals in soil and groundwater at the glassworks sites properties, all drinking water samples from households with private wells, located at a 30-640 m distance from a glassworks site, were below drinking water criteria from the WHO for Sb, As, Ba and Cd. A few drinking water samples showed concentrations of Pb above the WHO guideline, but As was the only element found in concentrations that could result in human exposure near toxicological reference values. An efficient retention of metals in the natural soil close to the source areas, which results in a moderate impact on local drinking water, is implied. Firstly, by the lack of significant difference in metal concentrations when comparing households located upstream and downstream of the main waste deposits, and secondly, by the lack of correlation between the metal concentration in drinking water and distance to the nearest glassworks site. However, elevated Pb and Cd concentrations in drinking water around glassworks sites when compared to regional groundwater indicate that diffuse contamination of the soils found outside the glassworks properties, and not only the glass waste landfills, may have a significant impact on groundwater quality. We further demonstrate that different mobilization patterns apply to different metals. Regarding the need to use reliable data to assess drinking water contamination and human exposure, we finally show that the conservative modelling approaches that are frequently used in routine risk assessments may result in exposure estimates many times higher than those based on measured concentrations in the drinking water that is actually being used for consumption. (C) 2016 Elsevier B.V. All rights reserved.
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| 2. |
- Karlson, Mårten, 1983-, et al.
(författare)
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Design and evaluation of railway corridors based on spatial ecological and geological criteria
- 2016
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Ingår i: Transportation Research Part D. - : Elsevier. - 1361-9209 .- 1879-2340. ; 46, s. 207-228
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Tidskriftsartikel (refereegranskat)abstract
- Transport infrastructure is closely linked to several sustainability issues of main policy relevance, and significant impacts on biodiversity as well as resource use and construction costs relate to the corridor design and location in the landscape. The aim of this study was to develop methods for railway corridor planning, in which corridor design and location would be based on important ecological and geological sustainability criteria. The method, an MCA framework including both spatial and non-spatial MCA, was demonstrated on a railway planning proposition in an urbanising area north of Stockholm, Sweden. Alternative spatial alignments for 6 railway corridors were derived based on criteria representing biodiversity, resource efficiency and costs, developed from ecological and geological knowledge, data and models. The method identified a study area specific positive synergy between ecological and geological sustainability criteria. The evaluation part of the methodology could furthermore identify uncertainties in the input data and assumptions and conflicts between ecological criteria. In order to arrive at a well-informed decision support system, the criteria as well as the decision rules employed could be further elaborated. Other relevant sustainability issues would also need to be integrated, such as cultural landscapes, recreation, and other ecosystem services. Still, arriving at a corridor design informed by the ecological and geological conditions in the planned area, as demonstrated by this study, could improve the sustainability performance of transport infrastructure planning.
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| 3. |
- Küpper, Frithjof C., et al.
(författare)
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Commemorating Two Centuries of Iodine Research : An Interdisciplinary Overview of Current Research
- 2011
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 50:49, s. 11598-11620
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Forskningsöversikt (refereegranskat)abstract
- Iodine was discovered as a novel element in 1811 during the Napoleonic Wars. To celebrate the bicentennial anniversary of this event we reflect on the history and highlight the many facets of iodine research that have evolved since its discovery. Iodine has an impact on many aspects of life on Earth as well as on human civilization. It is accumulated in high concentrations by marine algae, which are the origin of strong iodine fluxes into the coastal atmosphere which influence climatic processes, and dissolved iodine is considered a biophilic element in marine sediments. Iodine is central to thyroid function in vertebrates, with paramount implications for human health. Iodine can exist in a wide range of oxidation states and it features a diverse supramolecular chemistry. Iodine is amenable to several analytical techniques, and iodine compounds have found widespread use in organic synthesis. Elemental iodine is produced on an industrial scale and has found a wide range of applications in innovative materials, including semiconductorsin particular, in solar cells.
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| 4. |
- Mustjoki, S, et al.
(författare)
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Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients
- 2013
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 27:7, s. 1520-1526
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Tidskriftsartikel (refereegranskat)abstract
- Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not been systematically assessed. We prospectively analyzed the proportion of Philadelphia chromosome-positive leukemic stem cells (LSCs, Ph+CD34+CD38=) and progenitor cells (LPCs, Ph+CD34+CD38+) from 46 newly diagnosed CML patients both at the diagnosis and during imatinib or dasatinib therapy (ClinicalTrials.gov NCT00852566). At diagnosis, the proportion of LSCs varied markedly (1-100%) between individual patients with a significantly lower median value as compared with LPCs (79% vs 96%, respectively, P = 0.0001). The LSC burden correlated with leukocyte count, spleen size, hemoglobin and blast percentage. A low initial LSC percentage was associated with less therapy-related hematological toxicity and superior cytogenetic and molecular responses. After initiation of TKI therapy, the LPCs and LSCs rapidly decreased in both therapy groups, but at 3 months time point the median LPC level was significantly lower in dasatinib group compared with imatinib patients (0.05% vs 0.68%, P = 0.032). These data detail for the first time the prognostic significance of the LSC burden at diagnosis and show that in contrast to in vitro data, TKI therapy rapidly eradicates the majority of LSCs in patients.
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| 5. |
- Olofsson, Berit, 1972-
(författare)
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A Regio- and Stereodivergent Route to All Isomers of vic-Amino Alcohols
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The first part of this thesis describes a synthetic strategythat provides all eight possible isomers of a given vic-aminoalcohol starting from vinylepoxides. The value of a generalroute is evident, as several isomers are needed ininvestigations of structure-activity relationships forpharmacologically active derivatives, and for optimizing theperformance of chiral ligands containing the amino alcoholmoiety.Vinylepoxides, obtained in high enantiomeric excess, werering-opened both with inversion and retention ofstereochemistry, delivering two diastereomeric amino alcoholswith high regio- and stereoselectivity. Via ring-closure toaziridines and subsequent regioselective ring-opening withsuitable oxygen nucleophiles, the two remaining amino alcoholswere selectively achieved.Within this study, two efficient protocols for theregioselective and stereospecific aminolysis of vinylepoxideshave been presented. Comparedto previous methods, theseprocedures use milder reaction conditions, shorter reactiontimes, generally give higher yields and are applicable to alarger set of substrates. Furthermore, the ring-closure ofvic-amino alcohols to the corresponding N-H vinylaziridines hasbeen investigated. Three routes have been found useful, whichone is preferred depends on substrate and scale.In the second part of the thesis, the synthetic strategy isapplied on the synthesis of Sphingosine and its regio- andstereoisomers. Moreover, a rapid way of determining relativeconfiguration of vic-amino alcohols is described, which shouldbe of substantial use when amino alcohols are formed bydiastereoselective reactions.amino alcohols, vinylepoxides, vinylaziridines, oxazolines,oxazolidinones, ring-opening, regioselective,diastereoselective, sphingosine, configuration, NMRspectroscopy.
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| 6. |
- Olofsson, Berit, et al.
(författare)
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A regio- and stereodivergent route to all isomers of vic-amino alcohols
- 2002
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 67:24, s. 8574-8583
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Tidskriftsartikel (refereegranskat)abstract
- Vicinal amino alcohols are substructures in several important natural products. They are also frequently employed ligands in asymmetric synthesis. Many enantioselective syntheses of vic-amino alcohols have been reported, but each structure has required its own synthetic route. This study presents a synthetic strategy leading to all eight possible isomers of a given beta-amino alcohol, starting from vinyl epoxides. The developed strategy focuses on the propensity of vinyl epoxides and vinylaziridines to be selectively ring-opened at the allylic position by suitable hard nucleophiles. Within this strategy, a novel large-scale aminolysis reaction and the synthesis of a trisubstituted N-H vinylaziridine are detailed.
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| 7. |
- Olofsson, Berit, et al.
(författare)
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A regio- and stereodivergent synthesis of vic-amino alcohols
- 2000
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Ingår i: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 2:25, s. 4087-4089
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Tidskriftsartikel (refereegranskat)abstract
- [GRAPHICS] A regio- and stereodivergent synthesis of vic-amino alcohols starting from vinylepoxides is described. The developed strategy focuses on the propensity of vinylepoxides and vinylaziridines to be ring-opened at the allylic position by suitable nucleophiles and makes use of reactions that perform such tasks selectively with either retention or inversion of configuration.
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| 8. |
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| 9. |
- Olofsson, Berit, et al.
(författare)
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Determination of the relative configuration of vic-amino alcohols
- 2003
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Ingår i: Tetrahedron Letters. - 0040-4039 .- 1359-8562. ; 44:6, s. 1279-1281
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Tidskriftsartikel (refereegranskat)abstract
- A large set of syn- and anti-1,2-amino alcohols has been synthesized. Upon comparison of the CHO and CHN H-1 NMR shifts a general trend has been observed, making it possible to determine the relative configuration of 1,2-amino alcohols without derivatization or shift reagents.
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| 10. |
- Olofsson, Berit, et al.
(författare)
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Divergent synthesis of D-erythro-sphingosine, L-threo-sphingosine, and their regioisomers
- 2003
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 68:6, s. 2514-2517
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Tidskriftsartikel (refereegranskat)abstract
- Starting from a vinyl epoxide, a divergent synthesis of four sphingosine isomers is described. The remaining four isomers can easily be synthesized using the same methodology. Although numerous syntheses of sphingosine have been published, this is the first general route leading to all eight isomers in this important compound class. The synthetic strategy relies on regioselective opening of a vinyl epoxide and a vinylaziridine in the allylic position.
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