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Träfflista för sökning "WFRF:(Olsson Bob 1969 ) ;pers:(Andersson Per Ola 1964)"

Sökning: WFRF:(Olsson Bob 1969 ) > Andersson Per Ola 1964

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1.
  • Olsson, Bob, 1969, et al. (författare)
  • Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura.
  • 2005
  • Ingår i: Thrombosis and haemostasis. - 0340-6245. ; 93:1, s. 139-44
  • Tidskriftsartikel (refereegranskat)abstract
    • Idiopathic thrombocytopenic purpura (ITP) is an organ specific autoimmune disorder in which T-lymphocyte abnormalities have pathogenetic importance. In a DNA microarray screen of CD3+ T-lymphocytes from ITP patients and healthy controls we found an altered expression of genes associated with apoptosis, e.g. A20, caspase-8 and Bax. This together with our previous findings of increased gene expression of Fas, interferon-g and IL-2 receptor beta (IL2RB) indicated an altered activation induced cell death (AICD) of T-cells in ITP. Using a proliferation assay we found that CD3+ lymphocytes from ITP patients were significantly more resistant to dexamethasone induced suppression compared to normal lymphocytes. We also found that cultured CD3+ lymphocytes from ITP patients in remission were more susceptible to apoptosis both in the presence and absence of dexamethasone compared to cells from patient with active ITP and healthy controls, as indicated by increased staining of AnnexinV binding. Our findings suggest that apoptotic resistance of activated T-lymphocytes in patients with active ITP may lead to defective clearance of autoreactive T-lymphocytes through AICD, which might cause a continued immune destruction of platelets. Conversely, a loss of resistance to AICD in ITP patients in remission might be an important mechanism for the achievement of remission.
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2.
  • Olsson, Bob, 1969, et al. (författare)
  • T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.
  • 2003
  • Ingår i: Nature medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 9:9, s. 1123-4
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
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