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| 2. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 3. |
- Nyberg, Lena, 1979, et al.
(författare)
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A single-step competitive binding assay for mapping of single DNA molecules
- 2012
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 417:1, s. 404-408
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Tidskriftsartikel (refereegranskat)abstract
- Optical mapping of genomic DNA is of relevance for a plethora of applications such as scaffolding for sequencing and detection of structural variations as well as identification cif pathogens like bacteria and viruses. For future clinical applications it is desirable to have a fast and robust mapping method based on as few steps as possible. We here demonstrate a single-step method to obtain a DNA barcode that is directly visualized using nanofluidic devices and fluorescence microscopy. Using a mixture of YOYO-1, a bright DNA dye, and netropsin, a natural antibiotic with very high AT specificity, we obtain a DNA map with a fluorescence intensity profile along the DNA that reflects the underlying sequence. The netropsin binds to AT-tetrads and blocks these binding sites from YOYO-1 binding which results in lower fluorescence intensity from AT-rich regions of the DNA. We thus obtain a DNA barcode that is dark in AT-rich regions and bright in GC-rich regions with kilobasepair resolution. We demonstrate the versatility of the method by obtaining a barcode on DNA from the phage T4 that captures its circular permutation and agrees well with its known sequence.
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| 4. |
- Schömer, Eva, et al.
(författare)
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Grounding worker conditions in the procurement of social welfare services
- 2019
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Ingår i: Labour Law and the Welfare State. - Uppsala : Iustus. ; , s. 209-230
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This article examines ways in which Swedish municipalities steer the selection of providers when procuring welfare services in the areas of homecare and personal assistance. It focuses particularly on issues related to working conditions and occupational health and safety.1 In accordance with Sweden’s Freedom of Choice Act (Lag [2008:962] om valfrihetssystem, LOV), municipal authorities and regional county boards may choose to outsource their welfare services through public procurement to private competition by allowing individual users to choose their own providers of health care and social services. Those municipalities and counties that implement freedom of choice systems must do so under the legal requirements set out in LOV. For municipal governments, implementing a system of choice is optional, while for county governments, a choice system in primary health care is mandatory under chapter 5 of the Health and Medical Services Act (Hälso- och sjukvårdslagen |2017:30]). The LOV regulates the procurement process by which contracting authorities outsource services through procurements to competition, by allowing individual users to choose their own providers. The government, however, retains overall responsibility for the services provided, and users pay the same price no matter what provider they choose. Private providers are remunerated by municipalities at a flat rate for services rendered (LOV, chapter 4, sections 1–2). This means that while the public sector assumes all the financial risk, it no longer has any “direct” insight into the operations of homecare and/or personal assistance service providers. The Public Procurement Act (Lag [2016:1145] om offentlig upphandling, LOU), which entered into force on January 1, 2017, applies in parallel with the LOV. Sweden’s supervisory body for public procurement, the Competition Authority (Konkurrensverket), recently stated that “there are good opportunities for doing good business while also contributing to sustainable development and ensuring robust competition inthe marketplace.”2 The LOU stipulates that contracting authorities “shall treat suppliers equally and without discrimination and shall conduct procurements in a transparent manner. Further, procurements shall be conducted in accordance withthe principles of mutual recognition and proportionality” (chapter 4, section 1). The LOU further states that although no supplier may be intentionally either “unduly favored or disadvantaged” (chapter 4, section 2), it should nonetheless be possible for public procurements to “take environmental considerations, and social and labor law considerations into account...if the nature of the procurement so justifies” (chapter 4, section 3).
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| 5. |
- Selegård, Linnéa, et al.
(författare)
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Step by step rare-earth catalyzed SiOx annealing and simultaneous formation of Europium- silicide by low coverage of Eu doped Gd2O3 nanoparticles
- 2021
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Ingår i: Surface Science. - : Elsevier BV. - 0039-6028 .- 1879-2758. ; 704
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Tidskriftsartikel (refereegranskat)abstract
- We report the formation of silicide by annealing of a SiOx surface, with low coverage of Eu doped Gd2O3 nanoparticles. The annealing temperature required for removal of native oxide from the Si substrate decreases with close to 200 °C in presence of the nanoparticles. X-ray photoemission electron microscopy, low-energy electron microscopy and mirror electron microscopy are used to monitor the silicide formation and SiOx removal. Fragmentation of the nanoparticles is observed, and the SiOx layer is gradually removed. Eu migrates to clean Si areas during the annealing process, while Gd is found in areas where oxide is still present. This annealing process is clearly facilitated in the presence of rare-earth based nanoparticles, where nanoparticles are suggested to function as reaction sites to catalyze the oxygen removal and simultaneously form Eu based silicide. Reduction of the annealing temperature of SiOx substrates is also observed in presence of pure Eu3+ and Gd3+ ions. Simultaneous oxygen removal and EuSi formation enable this new rare-earth catalyzed annealing and silicide formation to find applications both within optoelectronics and processing microelectronic industry.
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| 6. |
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| 7. |
- Armstrong, Andrea, et al.
(författare)
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Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimers Disease
- 2014
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Ingår i: Neuromolecular medicine. - : Humana Press. - 1535-1084 .- 1559-1174. ; 16:1, s. 150-160
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Tidskriftsartikel (refereegranskat)abstract
- The success of future intervention strategies for Alzheimers disease (AD) will likely rely on the development of treatments starting early in the disease course, before irreversible brain damage occurs. The pre-symptomatic stage of AD occurs at least one decade before the clinical onset, highlighting the need for validated biomarkers that reflect this early period. Reliable biomarkers for AD are also needed in research and clinics for diagnosis, patient stratification, clinical trials, monitoring of disease progression and the development of new treatments. Changes in the lysosomal network, i.e., the endosomal, lysosomal and autophagy systems, are among the first alterations observed in an AD brain. In this study, we performed a targeted search for lysosomal network proteins in human cerebrospinal fluid (CSF). Thirty-four proteins were investigated, and six of them, early endosomal antigen 1 (EEA1), lysosomal-associated membrane proteins 1 and 2 (LAMP-1, LAMP-2), microtubule-associated protein 1 light chain 3 (LC3), Rab3 and Rab7, were significantly increased in the CSF from AD patients compared with neurological controls. These results were confirmed in a validation cohort of CSF samples, and patients with no neurochemical evidence of AD, apart from increased total-tau, were found to have EEA1 levels corresponding to the increased total-tau levels. These findings indicate that increased levels of LAMP-1, LAMP-2, LC3, Rab3 and Rab7 in the CSF might be specific for AD, and increased EEA1 levels may be a sign of general neurodegeneration. These six lysosomal network proteins are potential AD biomarkers and may be used to investigate lysosomal involvement in AD pathogenesis.
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| 8. |
- Bergsten, Linnea, et al.
(författare)
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Designing engaging computer based simulation games for increasing societal resilience to payment system
- 2020
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Ingår i: Proceedings of the 2020 the 3rd International Conference on Computers in Management and Business (ICCMB 2020) Session - Computer and Mobile Technology. - New York : Association for Computing Machinery (ACM). - 9781450376778 ; , s. 166-172, s. 166-172
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Konferensbidrag (refereegranskat)abstract
- Large or lengthy disruptions to the card payment system are threats that can cause crisis in society, especially in countries where other payment options are scarce. This paper presents a study that provides suggestions on how to improve a simulation game used to increase societal resilience to payment system disruptions. Questionnaires and interviews have been used to investigate how 16 participant in crisis exercises experience realism, relevance and validity in such exercises. Suggestions on how to improve the simulation game are provided, such as improvements to the graphical interface and introducing supporting roles from the exercise management.
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| 9. |
- Blommé, Linnéa, et al.
(författare)
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ILO-kommittén och ILO:s reglering av det nationella trepartsarbetet
- 2020
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Ingår i: Sverige och ILO. - Stockholm : Svenska ILO-kommittén. ; , s. 131-180
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Bokkapitel (populärvet., debatt m.m.)abstract
- Fokus i detta kapitel ligger på den svenska ILO-kommitténs verksamhet från 1977 till våra dagar (avsnitt 4). 1977 var ett avgörande år för ILO-kommittén. Genom ratifikationen av ILO:s konvention nr 144 om samråd på trepartsbasis för att främja genomförandet av ILO:s normer (1976) ändrades förutsättningarna för ILO-kommitténs verksamhet och kommittén fick en ny instruktion som arbetet ännu idag utgår ifrån. Det huvudsakliga syftet med kapitlet är att belysa ILO-kommitténs roll över tid och fånga in vissa utvecklingslinjer. Strukturen i avsnittet utgår från de uppgifter ILO-kommittén har enligt sin instruktion. Avsnitt 2 går dock längre tillbaka i tiden för att beskriva kommitténs tillkomsthistoria. I avsnitt 3 avhandlas bakgrund och framväxt av ILO:s konvention nr 144. I avsnitt 5 lyfts EU-medlemskapets inverkan på ILO-kommitténs arbete och i avsnitt 6 görs en jämförelse med övriga nordiska länders motsvarande organ. Avslutningsvis ges i avsnitt 7 några sammanfattande reflektioner.
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| 10. |
- Carlsson, Linnea, et al.
(författare)
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Desperately seeking industrial digital strategy : a dynamic capability approach
- 2021
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Ingår i: International Journal of Information Systems and Change Management. - : Inderscience Publishers. - 1479-3121 .- 1479-313X. ; 12:4, s. 345-364
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Tidskriftsartikel (refereegranskat)abstract
- This study focuses on managers’ perceptions of organisational capabilities for strategy formulation related to industrial digitalisation. A qualitative case study based on ten interviews in two manufacturing companies explores managers’ perceptions of industrial digitalisation. A dynamic capability framework, consisting of the organisational capabilities sensing, seizing, and transforming opportunities, is applied to recognise and analyse nuances in managers’ interpretation of prevailing organisational capabilities. Findings reveal that the studied companies have a limited maturity concerning knowledge, skills, and resources for industrial digitalisation which is needed in order to formulate a digital strategy. An additional core capability was discerned, i.e., ’seeking’. Seeking includes actions for articulating, appropriating, and involving in the very early phases of understanding and formulating a digital strategy. This article contributes to the existing dynamic capability framework by adding the core capability seeking illustrated in an elaborated and holistic ’dynamic capability loop’. The loop frames industrial digitalisation as a continuous process closely integrated with strategy formulation.
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