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| 2. |
- Wagner, W, et al.
(författare)
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Europe ambivalent on biotechnology
- 1997
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Ingår i: Nature. - London : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 387, s. 845-847
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Tidskriftsartikel (refereegranskat)abstract
- The Eurobarometer on Biotechnology (46.1) was conducted during October and November 1996. The survey conducted in each EU (European Union) country used a multi-stage random sampling procedure and provided a statistically representative sample of national residents aged 15 and over. The total sample within the EU was 16,246 respondents (about 1,000 per EU country). The survey questionnaire was designed by the authors as part of a larger study involving the comparative analysis of public perceptions, media coverage and public policy in relation to biotechnology from 1973 to the present.
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| 4. |
- Aili, Katarina, PhD, 1980-, et al.
(författare)
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Health-related quality of life in adults treated for paediatric acute lymphoblastic leukaemia: a cross-sectional and longitudinal cohort study
- 2022
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Ingår i: Bmj Open. - London : BMJ. - 2044-6055. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Acute lymphoblastic leukaemia (ALL) is the most common form of cancer in children. Although treatment methods have improved and resulted in significant improvement of survival and reduction in late effects and late mortality risk, the health-related quality of life (HRQOL) of survivors might be affected. To introduce new interventions in clinical practice with the potential to support positive HRQOL outcomes, more knowledge is needed on how HRQOL in this group is constructed and stimulated. The purpose of this study is to investigate how HRQOL is affected in adults treated for paediatric ALL, in a long-term perspective and possible factors influencing this relationship. Methods and analysis This cohort of young adult ALL survivors allows for investigations of factors influencing HRQOL outcomes on a national level. Eligible participants are obtained from the Swedish Childhood Cancer quality registry. Data collection includes both a follow-up of data collected in 2012 (n=224) and recruitment of new eligible participants to the cohort (n=601). The cohort will cover survivors of paediatric ALL, diagnosed between 1985 and 2007, at an age between 0 and 15 years. Data will be collected using validated, multidimensional, self-administered instruments, designed to measure HRQOL (SF-36), social support, sense of coherence and resilience. Ethics and dissemination The study will be carried out in accordance with the ethics permit obtained from the Swedish ethics review authority (Dnr 2019-05181). Dissemination of study results will take place through research articles and reports to the national patient organisation and the national network for consultancy nurses for this target group and to the working group for the Swedish national long-term care programme for childhood cancer. Results will also reach practical application within the follow-up clinic for adult childhood cancer survivors at Sahlgrenska Hospital in Gothenburg.
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| 5. |
- Andersson, Åsa, et al.
(författare)
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Effects on serum protein levels from one bout of high intensity interval training in individuals with axial spondyloarthritis and controls
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on disease activity and the level of inflammation in axSpA has been less studied. With the aim of investigating how levels of inflammatory cytokines, myokines, and protein markers for bone metabolism are acutely affected by one bout of HIIT, we studied serum from individuals with axSpA and healthy controls (HC). Methods: Ten participants with axSpA and 11 age- and sex-matched HC performed a single HIIT bout on a cycle ergometer: 4x4 minutes intervals with three minutes active rest in between. Blood samples were taken before and one hour after the HIIT bout. Serum proteins (IL-6, IL-17, IL-18, TNFa, CXCL-10, VEGF-A, BDNF, DKK-1, osteoprotegerin, osteocalcin, osteopontin, BMP-7, CRP) were analyzed with a Luminex system or ELISA. Descriptive data are presented as mean with standard deviation. A two-way ANOVA was used for comparisons. Results: A main effect from baseline to one hour post HIIT showed that both groups had a significant increase in serum levels (pg/ml) of IL-6: axSpA 2.2 (3.0) to 3.2 (1.8) and HC 0.4 (0.4) to 1.9 (2.0), p=0.03. VEGF-A (pg/ml) was significantly lower in the axSpA group: 159 (138) vs. HC 326 (184), p=0.03, but was not affected by the HIIT bout. BMP-7 (ng/ml) increased in both groups after the HIIT: axSpA 61.6 (13.1) to 75.2 (20.0) and HC 64.6 (20.8 to 75.0 (17.8), p<0.001. For the other proteins analyzed, there were no significant differences in serum concentrations between individuals with axSpA and HC, or within the two groups before and after one bout of HIIT. Conclusions: One acute bout of HIIT significantly increases the serum concentrations of IL-6 and BMP-7 after 1 hour in both individuals with axSpA and HC.
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| 6. |
- Andersson, Åsa, Professor, 1960-, et al.
(författare)
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Serum Protein Response To A Single High-Intensity Interval Training Bout – Comparison Between Individuals With Spondyloarthritis And Healthy Controls
- 2022
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Ingår i: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 81:Suppl 1, s. 780-781
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Tidskriftsartikel (refereegranskat)abstract
- Axial spondyloarthritis (axSpA) is a chronic inflammatory disease affecting mainly the axial skeleton. To decrease the risk of cardiovascular comorbidity, aerobic training is recommended as a part of disease management in patients with axSpA. High-intensity interval training (HIIT) interventions are, in addition to other recommended treatments, believed to positively affect the disease activity (1). However, the knowledge about the acute effects of HIIT on the inflammatory process at the molecular level is less studied. Understanding the acute HIIT effects on cytokines and additional serum proteins in axSpA is important for further long-term HIIT interventions and recording of the effect of HIIT on the axSpA disease profile.ObjectivesTo study the acute effects on serum proteins, such as cytokines, myokines, and inflammatory- and bone-related proteins, in response to a single bout of HIIT, and to compare the levels between baseline and post-HIIT in patients with axSpA and healthy controls (HC).MethodsThe pilot study included twenty-one participants (10 female, 11 male), mean (SD) age 40 (7) years, ten with axSpA, and eleven age and sex matched HC, who performed a single HIIT on a cycle ergometer consisting of 4x4 minutes interval (90% heart rate, HR-max) with three minutes active rest in between (70% of HR-max). Disease activity (BASDAI, 0-10) in patients with axSpA was 1.6 (0.8). Health status EuroQol (EQ5D, 0-1) were 0.87 (0.11) for axSpA, and 0.93 (0.10) for HC. The groups were well matched with no difference in baseline data for weight, BMI, EQ5D, blood pressure or aerobic capacity.Blood samples were taken before (baseline) and one hour after the single HIIT. The following serum proteins were analyzed on a Luminex MAGPIX System (Luminex corporation, Austin, TX USA): Interleukin (IL)-6, IL-17, IL-18, TNFαAGPIX System (Luminex corporatiosteoprotegerin, osteocalcin, osteopontin, and FGF-23. A three-way analysis of variance (ANOVA) was used to detect differences between groups, between sexes, and before and after a HIIT bout in a 2(group)*2(sex)*2(time) design. For main effects or interactions significant at p≤0.05, simple effect t-tests were used to determine the specific effects.ResultsA group main effect (p=0.048) showed that the serum level of IL-6 was increased one hour after the HIIT session primarily in the HC, 0.4 pg/ml (SD±0.4) at baseline vs. post-HIIT 1.8 (2.0). The concentration of the cytokines/chemokine IL-17, IL-18, TNFα group main effect (p=0.048) showed that the serum level of IL-6 was increased one hour after the HIIT session primarily in30) in VEGF-A showed that the axSpA group had significantly lower VEGF-A at baseline, 159 pg/ml (138) vs 326 (184) in the control group (which might be due to anti-inflammatory medication). A sex main effect (p=0.029) was observed from baseline to post-HIIT for the bone hormone osteocalcin, with a more pronounced decrease of serum osteocalcin in women with axSpA, 14.0 ng/ml (8.3) vs. post HIIT 13.2 (6.9). Moreover, the level of the multifunctional protein osteopontin was significantly lower (sex main effect, p=0.021) in women, 10.7 ng/ml (7.0) vs. men 20.4 (10.1), post-HIIT.ConclusionThis pilot study shows that one bout of HIIT influences the expression of proteins involved in inflammation and metabolism, and that sex is an important factor in the response to HIIT. The results should be followed up in longer intervention studies including higher numbers of participants.References[1]Sveaas, S. H. et al. (2019). High intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): a multicentre randomised trial of 100 patients. British journal of sports medicine, 54(5), 292-297.Disclosure of InterestsÅsa Andersson: None declared, Emma Haglund Consultant of: Novartis, Emma Berthold: None declared, Elisabeth Mogard Consultant of: Novartis, Anna Torell: None declared, M Charlotte Olsson: None declared
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| 7. |
- Arakelyan, Arsen, et al.
(författare)
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Functional Genetic Polymorphisms of Monocyte Chemoattractant Protein 1 and C-C Chemokine Receptor Type 2 in Ischemic Stroke
- 2014
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Ingår i: Journal of Interferon and Cytokine Research. - New Rochelle, NY : Mary Ann Liebert. - 1079-9907 .- 1557-7465. ; 34:2, s. 100-105
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Tidskriftsartikel (refereegranskat)abstract
- Recent findings indicated that monocyte chemoattractant protein 1 (MCP1) and its C-C chemokine receptor type 2 (CCR2) play a key role in ischemic stroke (IS) progression. This study was aimed at evaluating the potential association of the MCP1 gene (MCP1) rs1024611 (-2518 A>G) and CCR2 gene (CCR2) rs1799864 (V64I; 190 G>A) functional single nucleotide polymorphisms (SNPs) with IS in the Armenian population. For the purpose of this study, genomic DNA samples of 100 patients with the first-episode IS and 115 healthy subjects (controls) were genotyped for the selected SNPs using a polymerase chain reaction with sequence-specific primers. The results obtained demonstrated that while the CCR2 rs1799864 SNP genotypes were equally distributed among patients and controls, the frequency and carriage rate of the of the MCP1 rs1024611*G minor allele were higher in patients. While a potential association between IS and CCR2 rs1799864 SNP was evaluated for the first time, the latest finding was in agreement with the earlier data reported for some other populations. In summary, this study revealed no association of CCR2 rs1799864 SNP with IS, and a positive association between G minor allele of MCP1 rs1024611 SNP and IS in the Armenian population. Based on the present and earlier reported data, we concluded that the minor G allele of the MCP1 rs1024611 SNP might be considered a risk factor for IS.
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| 8. |
- Brorsson, Sofia, et al.
(författare)
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Maximal multiple repetitions in free weight strength training with different bar sizes
- 2010
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Konferensbidrag (refereegranskat)abstract
- INTRODUCTION: An individual’s grip strength is vital for performance of physical demanding tasks such as give some other example here? As well as strength training with free weights. Performing strength training with a thicker grip around the bar may enhance the strength of the grip in the athlete without other special routines for grip strength development. The purpose of this study was a) to examine the difference in performance in multiple repetitions in two strength training exercises using two different sizes on the bar, b) to investigate correlations between hand grip strength and the amount of repetitions performed with two different sizes of the bar and c) to correlate hand size with the amount of performed repetitions with two different bar sizes.METHODS: Fifteen male participants (24 ± 4 years) with at least one year of strength training experience performed bench press and a prone lying rowing exercise with two different bar sizes (normal Olympic lifting bar with and with out Fat Gripz™). The participants performed test of maximal number of repetitions at a level of 80% of one repetition maximum (1RM), hand size was measured as well as maximum grip strength (using JAMAR).RESULTS: The use of a thicker diameter bar resulted in 22 % (p<0.01) reduction of weight performance in number of performed repetitions in the bench press compared to the normal diameter of the bar. When performing lying bench row a 66 % (p<0.01) reduction in number of performed repetitions was seen with the thicker diameter of the bar. There was no significant correlation between hand size and the submaximal strength test (rp = 0,33 ; p = 0,23) or grip strength and submaximal strength test (rp = 0,31 ; p = 0,27).CONCLUSION: The results from this study indicated that the size of the bar diameter influences the performance in maximal number of repetitions in a prone lying rowing exercise and bench press. Further studies have to be done to analyses the effect of strength training with thicker bar.
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| 9. |
- Brorsson, Sofia, et al.
(författare)
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Maximal strength in one leg squat correlates with acceleration capacity and agility
- 2010
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Konferensbidrag (refereegranskat)abstract
- INTRODUCTION: In many intermittent team sports capacities such as speed, agility and explosiveness are important for performance and are evaluated by sprint-, agility- and strength tests. Earlier studies have shown strong correlations between strength in the two leg squat exercise and sprint performance in various distances but not in sprint performance in agility. Studies evaluating squat strength predominantly perform tests on two legs even when they test athletes involved in intermittent sports where sprinting and agility are common features. Thus, the purpose of this study was to investigate the correlation between maximal strength in a one leg squat (Bulgarian split squat) and acceleration capacity in various sprint distances and agility.METHODS: The test group consisted of 19 men (mean age 24 ± 2 years ) with experience in intermittent team sports. Acceleration capacity was assessed by sprint tests at 5, 10 and 20 meters and agility was evaluated using the zigzag agility test. The timing was made using photocells (Muscle lab,Ergotest Technology,Norway). The Bulgarian split squat was performed in a smith machine with the barbell on the shoulders to a depth of 110 degrees between tibia and femur.RESULTS: The results show significant correlation between maximal strength in the Bulgarian split squat and sprint capacity in the 5 and 10 meter sprint test (Rp= -0,56; p<0.01) as well as the agility test. Maximal strength relative to bodyweight showed significant correlation with the 5 and 20 meter sprint (Rp=-0,62; p< 0,01) as well as the agility test. The zigzag agility test also showed significant correlation between all distances in the sprint tests (p<0.01).CONCLUSION: The results from this study show that there maximal strength in one leg correlate significantly with both acceleration capacity and agility. Implementing one leg exercises in the strength and conditioning routine can be useful for athletes in intermittent sports wanting to improve agility and short sprinting capacity. Further implications is that the Bulgarian split squat could be a more functional test for agility performance than the squat on two legs which predominantly is being used today.
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| 10. |
- Brorsson, Sofia, et al.
(författare)
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Training program for young female soccer players with focus on increasing the acceleration capacity
- 2010
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Konferensbidrag (refereegranskat)abstract
- INTRODUCTION: Soccer is the world’s most popular team sport with over 240 million players around the world. About 20 million of the 240 million players are women and 80% of these women are adolescence or juniors. Acceleration capacity is one of the most important physical qualities for a soccer player. The aim of this study was to design, perform and evaluate a training program for young female soccer players with focus on increasing the acceleration capacity.METHODS: There were 22 young females (14,6 ± 1,0 years, 50,3 ± 5,1 kg, 160,2 ± 3,0 cm) from two different soccer teams participating. They were split into two groups, one test group (TG) (n=8) and one control group (CG) (n=14). The training period was 12 weeks, with soccer training 3 times per week for both groups. In the TG one workout per week was specifically designed to increase the acceleration capacity and took about 40 minutes to perform. The acceleration capacity was evaluated by a sprint test of 10-20-30 meter and vertical countermovement jump test using photocells. RESULTS: The TG showed a tendency to increased acceleration at the sprint test (p=0,08) and significant improvement at the jump test (p<0.05) after 12 weeks of training. The acceleration training also showed significant correlations between the sprint- and jump test in the TG after completed the 12 week training period (p<0.05). The CG showed decreased acceleration at the sprint test (p<0.05) and the vertical jump height was not significantly different. There were no significant differences between the two groups pre and post training.CONCLUSION: A 12 week training program can increase the acceleration capacity and the vertical jump height on young female soccer players. In sport were acceleration capacity is important it seems relevant to specifically train those qualities.
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