Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Olsson Marita 1965 ) "

Sökning: WFRF:(Olsson Marita 1965 )

  • Resultat 1-10 av 35
  • [1]234Nästa
Sortera/gruppera träfflistan
  • Hedelin, M., et al. (författare)
  • Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33 000 women from the general population
  • 2010
  • Ingår i: BMC Psychiatry. - 1471-244X. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Low intake of fish, polyunsaturated fatty acids (PUFA) and vitamin D deficiency has been suggested to play a role in the development of schizophrenia. Our aim was to evaluate the association between the intake of different fish species, PUFA and vitamin D and the prevalence of psychotic-like symptoms in a population-based study among Swedish women. Methods: Dietary intake was estimated using a food frequency questionnaire among 33 623 women aged 30-49 years at enrolment (1991/92). Information on psychotic- like symptoms was derived from a follow-up questionnaire in the years 2002/03. Participants were classified into three predefined levels: low, middle and high frequency of symptoms. The association between diet and psychotic- like symptoms was summarized in terms of relative risks (RR) and corresponding 95% confidence intervals and was evaluated by energy-adjusted multinomial logistic regression. Results: 18 411 women were classified as having a low level of psychotic- like symptoms, 14 395 as middle and 817 as having a high level. The risk of high level symptoms was 53% (95% CI, 30-69%) lower among women who ate fish 3-4 times per week compared to women who never ate fish. The risk was also lower for women with a high intake of omega-3 and omega-6 PUFA compared to women with a lower intake of these fatty acids. The effect was most pronounced for omega-6 PUFAs. The RR comparing the highest to the lowest quartile of omega-6 PUFAs intake was 0.78 (95% CI, 0.64-0.97). The associations were J-shaped with the strongest reduced risk for an intermediate intake of fish or PUFA. For fatty fish (herring/mackerel, salmon-type fish), the strongest inverse association was found for an intermediate intake (RR: 0.81, 95% CI, 0.66-0.98), whereas a high intake of fatty fish was associated with an increased risk of psychotic- like symptoms (RR: 1.90, 95% CI, 1.34-2.70). Women in the highest compared with the lowest quartile of vitamin D consumption experienced a 37% (95% CI, 22-50%) lower risk of psychotic- like symptoms. Conclusion: Our findings raise a possibility that adult women with a high intake of fish, omega-3 or omega-6 PUFA and vitamin D have a lower rate of psychotic- like symptoms.
  • Hov, J. R., et al. (författare)
  • Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis
  • 2011
  • Ingår i: Hepatology. - 1527-3350 .- 0270-9139. ; 53:6, s. 1967-1976
  • Tidskriftsartikel (refereegranskat)abstract
    • The strongest genetic risk factors for primary sclerosing cholangitis (PSC) are found in the human leukocyte antigen (HLA) complex at chromosome 6p21. Genes in the HLA class II region encode molecules that present antigen to T lymphocytes. Polymorphisms in these genes are associated with most autoimmune diseases, most likely because they contribute to the specificity of immune responses. The aim of this study was to analyze the structure and electrostatic properties of the peptide-binding groove of HLA-DR in relation to PSC. Thus, four-digit resolution HLA-DRB1 genotyping was performed in 356 PSC patients and 366 healthy controls. Sequence information was used to assign which amino acids were encoded at all polymorphic positions. In stepwise logistic regressions, variations at residues 37 and 86 were independently associated with PSC (P = 1.2 x 10(-32) and P = 1.8 x 10(-22) in single-residue models, respectively). Three-dimensional modeling was performed to explore the effect of these key residues on the HLA-DR molecule. This analysis indicated that residue 37 was a major determinant of the electrostatic properties of pocket P9 of the peptide-binding groove. Asparagine at residue 37, which was associated with PSC, induced a positive charge in pocket P9. Tyrosine, which protected against PSC, induced a negative charge in this pocket. Consistent with the statistical observations, variation at residue 86 also indirectly influenced the electrostatic properties of this pocket. DRB1*13:01, which was PSC-associated, had a positive P9 pocket and DRB1*13:02, protective against PSC, had a negative P9 pocket. Conclusion: The results suggest that in patients with PSC, residues 37 and 86 of the HLA-DR beta chain critically influence the electrostatic properties of pocket P9 and thereby the range of peptides presented. (HEPATOLOGY 2011;53:1967-1976)
  • Næss, Sigrid, et al. (författare)
  • Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
  • 2014
  • Ingår i: PLoS ONE. - 1932-6203. ; 9:12, s. e114486
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic variants within the major histocompatibility complex (MHC) represent the strongest genetic susceptibility factors for primary sclerosing cholangitis (PSC). Identifying the causal variants within this genetic complex represents a major challenge due to strong linkage disequilibrium and an overall high physical density of candidate variants. We aimed to refine the MHC association in a geographically restricted PSC patient panel.
  • Sim, S, et al. (författare)
  • Association between CYP2C19 polymorphism and depressive symptoms
  • 2010
  • Ingår i: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. - 1552-485X. ; 153B:6, s. 1160-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Cytochrome P450 2C19 (CYP2C19) is a polymorphic enzyme active in the metabolism of for example diazepam and the antidepressants sertraline, citalopram, and escitalopram, whereby allelic variants cause increased (CYP2C19*17) or abolished (mainly CYP2C19*2) enzymatic activity in drug metabolism. In light of the importance of CYP2C19 in the metabolism of psychoactive substances we considered it of interest to investigate the relationship between CYP2C19 polymorphisms and depressive symptoms in 1,472 subjects of European ancestry (45-98 years old) from the Swedish Twin Registry. Depressive symptoms were assessed using the Center of Epidemiologic Studies Depression (CES-D) scale. We found that poor metabolizers lacking CYP2C19 activity (PMs, CYP2C19*2/*2) had significantly lower levels of depressive symptoms than extensive metabolizers (EMs, CYP2C19*1/*1) (P = 0.0018). The size of this difference was in the same range as that between subjects reported taking antidepressants (n = 104) and those without antidepressant treatment (P
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 35
  • [1]234Nästa
fritt online (3)
Typ av publikation
tidskriftsartikel (32)
konferensbidrag (1)
doktorsavhandling (1)
licentiatavhandling (1)
Typ av innehåll
refereegranskat (32)
övrigt vetenskapligt (3)
Olsson, M. (9)
Lind, Marcus, 1976-, (9)
Gudbjörnsdottir, Sof ... (7)
Rosengren, Annika, 1 ... (7)
Lie, Benedicte A (6)
Svensson, A. M. (6)
visa fler...
Lie, BA (5)
Warnhammar Finnborg, ... (4)
Hultborn, Ragnar, 19 ... (3)
Karlsen, Tom H (3)
Bergquist, A, (3)
Skrtic, Stanko, 1970 ... (2)
Kockum, I. (2)
Karlsen, TH (2)
Boberg, KM (2)
Humphreys, K, (2)
Schrumpf, Erik (2)
Weiderpass, E, (1)
Pedersen, NL, (1)
Hampe, Jochen, (1)
Nilsson, Staffan, 19 ... (1)
Johansson, S, (1)
Bergquist, Annika (1)
Boberg, Kirsten Muri (1)
Ingelman-Sundberg, M ... (1)
Löf, Marie (1)
Hampe, J (1)
Schreiber, S., (1)
Franke, A (1)
Jensen, H. (1)
Lewander, T, (1)
Weiderpass, Elisabet ... (1)
Gudjonsdottir, Audur ... (1)
Ascher, Henry, 1953- (1)
Nilsson, B (1)
Svensson, Ann-Marie, ... (1)
Ahlberg, Daniel, 198 ... (1)
Hedelin, M., (1)
Ripatti, Samuli (1)
Spurkland, A (1)
Sandberg-Wollheim, M (1)
Larsson, Marita, (1)
Naessén, Tord, (1)
Sparen, P, (1)
von Knorring, Anne-L ... (1)
Bohman, Hannes, 1965 ... (1)
Jonsson, Ulf, 1974-, (1)
Palmgren, J, (1)
Melum, Espen (1)
Schreiber, Stefan (1)
visa färre...
Göteborgs universitet (34)
Chalmers tekniska högskola (34)
Karolinska Institutet (9)
Uppsala universitet (1)
Engelska (35)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (26)
Naturvetenskap (11)


pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy