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Cognitive function predicts work disability among multiple sclerosis patients

Kavaliunas, Andrius (författare)
Karolinska Institutet
Tinghög, Petter (författare)
Röda Korsets Högskola,Hälsovetenskapliga institutionen,Karolinska Institutet
Friberg, Emilie (författare)
Karolinska Institutet
visa fler...
Olsson, Tomas (författare)
Karolinska Institutet
Alexanderson, Kristina (författare)
Karolinska Institutet
Hillert, Jan (författare)
Karolinska Institutet
Karrenbauer, Virginija Danylaite (författare)
Karolinska Institutet
visa färre...
 (creator_code:org_t)
2019-01-14
2019
Engelska.
Ingår i: Multiple Sclerosis Journal, Experimental, Translational and Clinical. - : Sage Publications. - 2055-2173. ; 5:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: In multiple sclerosis various aspects of cognitive function can be detrimentally affected. More than that, patients´ employment and social functioning is likely to be impacted.Objective: To determine whether work disability among multiple sclerosis patients could be predicted by the symbol digit modalities test.Methods: A register-based cohort study was conducted. Individual data on work disability, operationalised as annual net days of sickness absence and/or disability pension were retrieved at baseline, when the symbol digit modalities test was performed, after one-year and 3-year follow-up for 903 multiple sclerosis patients. The incidence rate ratios for work disability were calculated with general estimating equations using a negative binomial distribution and were adjusted for gender, age, educational level, family composition, type of living area and physical disability.Results: After one year of follow-up, the patients in the lowest symbol digit modalities test quartile were estimated to have a 73% higher rate of work disability when compared to the patients in the highest symbol digit modalities test quartile (incidence rate ratio 1.73, 95% confidence interval 1.42‒2.10). This estimate after 3-year follow-up was similar (incidence rate ratio 1.68, 95% confidence interval 1.40‒2.02).Conclusion: Cognitive function is to a high extent associated with multiple sclerosis patients' future work disability, even after adjusting for other factors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- General Practice (hsv//eng)

Nyckelord

Multiple sclerosis
cognition
employment
prognosis
socioeconomic factors
work

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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