| 1. |
- South, Nicholas, et al.
(författare)
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Väderradarteknik inom VA-området : Test av metodik
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The report consists of a literature study of X-band weather radar technology, a comparison of rain data between an X-band radar facility near Lund and rain gauges, an analysis of flow- and sewage overflow data during rain events and implementation ideas of the X-band radar.
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| 2. |
- Arenaz Búa, Beatriz, et al.
(författare)
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The Pharyngoesophageal Segment after Total Laryngectomy
- 2017
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Ingår i: Annals of Otology, Rhinology and Laryngology. - : SAGE Publications. - 0003-4894 .- 1943-572X. ; 126:2, s. 138-145
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of the present study was to characterize the pharyngoesophageal segment in laryngectomees who rated themselves as functional tracheoesophageal speakers. Methods: Voice perceptual assessment, high-resolution videomanometry of swallowing and phonation, and high-speed camera recording during phonation provided information about the anatomy and function of the pharyngoesophageal segment. Results: Fourteen patients were included in the study. The voice assessments presented high intra/inter-listener reliability. We found a significant correlation between roughness and poor voice quality, hyperfunction and poor intelligibility, and poor voice quality, long time since the operation, and old age. High-resolution videomanometry during phonation revealed decreasing mean pressures from the distal esophagus to the pharynx and confirmed low resting pressures at the pharyngoesophageal segment and low esophageal peristaltic contraction pressures after laryngectomy in comparison to normal subjects. The neoglottis shape was mainly circular and presented a strong mucosal wave in most of the patients on the high-speed camera recording. Conclusions: Perceptual voice assessment and high-speed camera recordings provided baseline information about voice characteristics and vibration regularity of the neoglottis. Additionally, the quantitative measures obtained with high-resolution videomanometry may have clinical applicability as reference data in voice rehabilitation after total laryngectomy.
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| 3. |
- Arenaz Bua, Beatriz, et al.
(författare)
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Treatment of cricopharyngeal dysfunction: a comparative pilot study.
- 2015
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Ingår i: BMC Research Notes. - : Springer Science and Business Media LLC. - 1756-0500. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Cricopharyngeal dysfunction is a narrowing at the level of the upper oesophageal sphincter caused by failed or incomplete sphincter opening as a result of lack of pharyngoesophageal coordination or reduction in the muscular compliance of the upper oesophageal sphincter. Oropharyngeal dysphagia is a typical symptom. Videomanometry allows direct comparison of pressure readings with dynamic anatomy during swallowing.
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| 4. |
- Burmakin, Mikhail, et al.
(författare)
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Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma
- 2017
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Ingår i: Journal of Translational Medicine. - : BioMed Central. - 1479-5876. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Background: Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model. Methods: We compared the effects of imatinib on oxygen levels, vascular morphology and IFP in three experimental tumor models differing in their content of a collagenous extracellular matrix. Results: Neither the KAT4 and CT-26 colonic carcinoma models, nor B16BB melanoma expressed PDGF beta-receptors in the malignant cells. KAT-4 tumors exhibited a well-developed ECM in contrast to the other two model systems. The collagen content was substantially higher in KAT-4 than in CT-26, while collagen was not detectable in B16BB tumors. The pO(2) was on average 5.4, 13.9 and 19.3 mmHg in KAT-4, CT-26 and B16BB tumors, respectively. Treatment with imatinib resulted in similar pO(2)-levels in all three tumor models but only in KAT-4 tumors did the increase reach statistical significance. It is likely that after imatinib treatment the increase in pO(2) in KAT-4 tumors is caused by increased blood flow due to reduced vascular resistance. This notion is supported by the significant reduction observed in IFP in KAT-4 tumors after imatinib treatment. Vessel area varied between 4.5 and 7% in the three tumor models and was not affected by imatinib treatment. Imatinib had no effect on the fraction of proliferating cells, whereas the fraction of apoptotic cells increased to a similar degree in all three tumor models. Conclusion: Our data suggest that the effects of imatinib on pO(2)-levels depend on a well-developed ECM and provide further support to the suggestion that imatinib acts by causing interstitial stroma cells to produce a less dense ECM, which would in turn allow for an increased blood flow. The potential of imatinib treatment to render solid tumors more accessible to conventional treatments would therefore depend on the degree of tumor desmoplasia.
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| 5. |
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| 6. |
- Ståhl, Fredrik, et al.
(författare)
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Kernel-based Estimate of the Insulin Action of Rapid-Acting Insulin in Home-Monitored Data
- 2015
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Ingår i: IFAC-PapersOnLine. - : Elsevier BV. - 2405-8963. ; 48:28, s. 715-720
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Tidskriftsartikel (refereegranskat)abstract
- To improve glycemic control in insulin-dependent diabetes, estimates of the glucose- lowering effect of insulin-the insulin action (IA)-and the dynamics thereof are essential. The current practice relies on generic estimates of the dynamic shape of the IA and rules-of-thumb to assess the total glucose-lowering effect. In this paper we present individualized estimates based on home-monitored data, incorporating a kernel-based estimate that also accounts for the nonlinear behavior of the IA across the glucose range. The method is successfully validated on 29 patients on continuous insulin pump therapy.
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| 7. |
- Ståhl, Fredrik, et al.
(författare)
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Predicting Nocturnal Hypoglycemia Using a Non-Parametric Insulin Action Model
- 2015
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Ingår i: 2015 IEEE International Conference on Systems, Man, and Cybernetics (SMC). - 1062-922X. ; , s. 1583-1588
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Konferensbidrag (refereegranskat)abstract
- Nocturnal hypoglycemia is a common and potentially very dangerous condition facing persons with insulin-treated diabetes. To reduce the risk of going low while sleeping, many patient wilfully elevate their glucose level before bedtime, thereby also eroding the conditions for a sound glucose control for the next day. Recent advances in sensor technology allow for real-time frequent monitoring of the glucose level, and the road map towards an artificial pancreas involves combining an insulin pump with such sensors. The first steps towards a more autonomous insulin pump have been taken by allowing the pump to suspend the insulin supply when a hypoglycemic episode is imminent. This feature relies on algorithms for predicting the nocturnal event. In this paper, we present a novel model for this purpose. In comparison to previous methods, a better trade-off between sensitivity and false alarm rate was achieved, as well as improved warning time.
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