| 1. |
- Dominguez, Cecilia A., et al.
(författare)
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The DQB1*03:02 HLA haplotype is associated with increased risk of chronic pain after inguinal hernia surgery and lumbar disc herniation
- 2013
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Ingår i: Pain. - : Ovid Technologies (Wolters Kluwer Health). - 0304-3959 .- 1872-6623. ; 154:3, s. 427-433
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Tidskriftsartikel (refereegranskat)abstract
- Neuropathic pain conditions are common after nerve injuries and are suggested to be regulated in part by genetic factors. We have previously demonstrated a strong genetic influence of the rat major histocompatibility complex on development of neuropathic pain behavior after peripheral nerve injury. In order to study if the corresponding human leukocyte antigen complex (HLA) also influences susceptibility to pain, we performed an association study in patients that had undergone surgery for inguinal hernia (n = 189). One group had developed a chronic pain state following the surgical procedure, while the control group had undergone the same type of operation, without any persistent pain. HLA DRB1genotyping revealed a significantly increased proportion of patients in the pain group carrying DRB1*04 compared to patients in the pain-free group. Additional typing of the DQB1 gene further strengthened the association; carriers of the DQB1*03:02 allele together with DRB1*04 displayed an increased risk of postsurgery pain with an odds risk of 3.16 (1.61-6.22) compared to noncarriers. This finding was subsequently replicated in the clinical material of patients with lumbar disc herniation (n = 258), where carriers of the DQB1*03:02 allele displayed a slower recovery and increased pain. In conclusion, we here for the first time demonstrate that there is an HLA-dependent risk of developing pain after surgery or lumbar disc herniation; mediated by the DRB1*04 - DQB1*03:02 haplotype. Further experimental and clinical studies are needed to fine-map the HLA effect and to address underlying mechanisms.
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| 2. |
- Ek, Staffan, et al.
(författare)
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Relative Age Effect of Sport Academy Adolescents, a Physiological Evaluation
- 2020
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Ingår i: Sports. - Basel : MDPI. - 2075-4663. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- The relationship between birth quarter distribution and physiological characteristics related to athletic skills, in adolescent sport academy students has not been fully investigated. In a cross-sectional study, we recruited 86 boys and 52 girls aged 12-14 years during their first term at a sport academy school. We measured body size, cardiac size, pulmonary function, body composition, lower body power, cardiorespiratory fitness parameters, and running endurance by standard methods and analyzed these estimates in relation to birth quarter by ANOVA. Birth quarter distribution in our cohort was compared with birth quarter distribution in the same ages in the whole of Sweden and analyzed by logistic regression. The academy had an overrepresentation of students born in the first quartile of the year compared to those born in the last quartile (odds ratio 2.3 (95% CI: 1.1-4.7)). When comparing the physiological characteristics between birth quarters, uniformity is prominent since out of 26 performed physiological and anthropometric tests only four showed statistically significant group differences. We thus believe that the selection process to the sport academy favours athletes with higher chronological age, i.e., a so-called relative age effect is present. © 2020 MDPI (Basel, Switzerland).
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| 3. |
- Gerostathopoulos, Ilias, et al.
(författare)
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Continuous Data-driven Software Engineering : Towards a Research Agenda
- 2019
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Ingår i: Software Engineering Notes. - : Association for Computing Machinery (ACM). - 0163-5948 .- 1943-5843. ; 44:3, s. 60-64
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Tidskriftsartikel (refereegranskat)abstract
- The rapid pace with which software needs to be built, together with the increasing need to evaluate changes for end users both quantitatively and qualitatively calls for novel software engineering approaches that focus on short release cycles, continuous deployment and delivery, experiment-driven feature development, feedback from users, and rapid tool-assisted feedback to developers. To realize these approaches there is a need for research and innovation with respect to automation and tooling, and furthermore for research into the organizational changes that support flexible data-driven decision-making in the development lifecycle. Most importantly, deep synergies are needed between software engineers, managers, and data scientists. This paper reports on the results of the joint 5th International Workshop on Rapid Continuous Software Engineering (RCoSE 2019) and the 1st International Workshop on Data-Driven Decisions, Experimentation and Evolution (DDrEE 2019), which focuses on the challenges and potential solutions in the area of continuous data-driven software engineering.
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| 4. |
- Peterson, Tomas, et al.
(författare)
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Malmö Youth Sport Study : A longitudinal study of a secondary school in Malmö, Sweden, specialized in physical activity and sports
- 2017
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Ingår i: Idrottsforum.org/Nordic sport science forum. - : Idrottsforum.org. - 1652-7224. ; :2017-12-04
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This is a presentation of the longitu- dinal and multidisciplinary research program Malmö Youth Sport Study (MYSS), which is an independent continuation of the Bunke o project. The aims, methods, empirical materials and theoretical basis are introduced. The study asks questions related to the role of physical activity and sports to promote an active lifestyle and to foster elite athletes. The longitudinal study involves 156 individuals engaged in thirteen different sports, from a secondary school in Malmö, Sweden, specialized in physical activity and sports. school form contributes to pupils taking part in competitive or rec- reational sports in adulthood to a greater extent than their peers at or- dinary schools. The overall aim with the MYSS study is both to answer these two questions empirically, and to investigate which selection factors (gender-related, physiologi- cal, social, or psychological) could be used to explain the outcomes. A three year follow-up is analyzed at the present time. There will also be a six year follow-up and a twelve year follow-up. Two basic questions to be an- swered are, rst, if this school form contributes to a larger extent to fos- ter elite athletes, and, second, if this The researchers represent disci- plines within Humanities, Medicine, and Social Sciences, and they are af liated to three Swedish universi- ties.
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