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N-acetylcysteine de...
N-acetylcysteine decreases dopamine transporter availability in the non-lesioned striatum of the 6-OHDA hemiparkinsonian rat
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- Virel, Ana (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Johansson, Jarkko (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Axelsson, Jan, 1966- (author)
- Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Ericsson, Madelene (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Laterveer, Rutger (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Ögren, Mattias (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Orädd, Greger (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Jakobson Mo, Susanna (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- af Bjerkén, Sara (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Neurovetenskaper
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Neuroscience Letters. - : Elsevier. - 0304-3940 .- 1872-7972. ; 770
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- This study aimed to explore the beneficial effects of the antioxidant N-acetylcysteine (NAC) on the degenerated dopamine system. The short- and long-term regulatory mechanisms of NAC on the 6-OHDA hemiparkinsonian rat model were longitudinally investigated by performing positron emission tomography (PET) imaging using the specific dopamine transporter (DAT) radioligand [18F]FE-PE2I. The results demonstrate that after a unilateral dopamine insult NAC has a strong influence on the non-lesioned hemisphere by decreasing the levels of DAT in the striatum early after the lesion. We interpret this early and short-term decrease of DAT in the healthy striatum of NAC-treated animals as a beneficial compensatory effect induced by NAC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- 6-OHDA
- N-acetylcysteine
- Neuroimaging
- Parkinson's disease
- PET
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Virel, Ana
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Johansson, Jarkk ...
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Axelsson, Jan, 1 ...
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Ericsson, Madele ...
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Laterveer, Rutge ...
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Ögren, Mattias
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Orädd, Greger
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Jakobson Mo, Sus ...
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af Bjerkén, Sara
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neuroscience Let ...
- By the university
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Umeå University