| 1. |
- Nilsson, Kent W., et al.
(författare)
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Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity
- 2006
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Ingår i: Biological Psychiatry. - Uppsala Univ, Clin Res Ctr, Cent Hosp Vasteras, S-72189 Vasteras, Sweden. Uppsala Univ, Dept Neurosci, Pharmacol Unit, S-72189 Uppsala, Sweden. : Elsevier. - 0006-3223 .- 1873-2402. ; 59:2, s. 121-127
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A number of important sociological, psychological, and biological predictors of adolescent criminal behavior have been identified during the most recent decades. The aim of this study was to replicate recent findings that interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter region and psychosocial factors might predict male adolescent criminal activity.METHODS: A cross-sectional study with a randomized sample from the total population of 16- and 19-year-olds from the county of Västmanland, Sweden. Eighty-one male adolescents, who volunteered to participate, were randomly selected from groups representing different degrees of deviant risk behavior.RESULTS: The present study strongly supports the notion that carrying the 3-repeat allele of the MAO-A-gene promoter increases the risk of male adolescent criminal behavior, when interacting with psychosocial factors. No effects at all of the MAO-A genotype on adolescent criminal activity were found when MAO-A genotype was considered alone (i.e., without its psychosocial context). The explained variance of the bio-psychosocial model (controlling for MAO-A) in this study exceeded the psychosocial model by 12%.CONCLUSIONS: The findings support the notion that genotype and psychosocial factors interact to precipitate male adolescent criminal behavior.
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| 2. |
- Nilsson, Kent W., et al.
(författare)
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Role of the serotonin transporter gene and family function in adolescent alcohol consumption.
- 2005
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Ingår i: Alcoholism. - Uppsala Univ, Clin Res Ctr, Cent Hosp Vasteras, S-72189 Vasteras, Sweden. Uppsala Univ, Dept Neurosci, Pharmacol Unit, S-72189 Vasteras, Sweden. : Wiley-Blackwell Publishing Inc.. - 0145-6008 .- 1530-0277. ; 29:4, s. 564-570
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: That the extent to which a particular individual will engage in problematic behaviors such as delinquency, violence, or drug abuse is determined by the way psychosocial, situational, and hereditary factors interact is widely accepted. However, only recently have researchers begun to investigate the interactions between specific genotypes and psychosocial factors in relation to behavior. The purpose of the present study was to investigate possible interactions between a polymorphism in the promoter region of the serotonin transporter (5-HTT) gene and family relations on adolescent alcohol consumption.METHODS: A cross-sectional study with a randomized sample from a total population of 16- and 19-year-old adolescents from a Swedish county was conducted. Eighty-one male and 119 female adolescents, who volunteered to participate after having answered a questionnaire, were randomly selected from quartiles of volunteers representing various degrees of psychosocial risk behavior.RESULTS: 5-HTT genotype (p=0.029) and family relations (p=0.022) predicted alcohol consumption independently as well as through an interaction with one another (p=0.05). The model explained 11% of the variance in alcohol consumption. In a binary logistic model, we found that adolescents with the LS variant of the 5-HTT gene and with family relations being "neutral" or "bad" had a 12- to 14-fold increased risk for high intoxication frequency.CONCLUSIONS: In sum, our results show that a functional polymorphism of the 5-HTT genotype, family relations, and interactions between these variables predict adolescent alcohol consumption in a randomized sample of adolescents.
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| 3. |
- Nilsson, Kent W, et al.
(författare)
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Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology.
- 2009
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Ingår i: Journal of neural transmission. - : Springer Science and Business Media LLC. - 0300-9564 .- 1435-1463. ; 116:3, s. 363-370
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate possible interactions between the gene coding for activating protein-2 beta (AP-2 beta) and psychosocial factors to predict depressive symptoms in adolescents. Two-hundred 16- and 19-year-old adolescents from the county of Västmanland, Sweden, were asked to complete a questionnaire, interviewed about psychosocial risk factors, and genotyped with regard to the transcription factor AP-2 beta intron 2 polymorphism. AP-2 beta genotype interacted significantly both with type of housing and parental separation to predict depressive symptoms. Individuals who were homozygous for the short AP-2 beta allele displayed higher depression scores when psychosocial adversity was taken into account. Amongst carriers of one or two copies of the long allele, there was no difference in depressive symptoms despite differences in psychosocial environments.
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