Blood Pressure Loci Identified with a Gene-Centric Array.

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Blood Pressure Loci Identified with a Gene-Centric Array.

Johnson, Toby (author)

Gaunt, Tom R (author)

Newhouse, Stephen J (author)

Padmanabhan, Sandosh (author)

Tomaszewski, Maciej (author)

Kumari, Meena (author)

Morris, Richard W (author)

Tzoulaki, Ioanna (author)

O'Brien, Eoin T (author)

Poulter, Neil R (author)

Sever, Peter (author)

Shields, Denis C (author)

Thom, Simon (author)

Wannamethee, Sasiwarang G (author)

Whincup, Peter H (author)

Brown, Morris J (author)

Connell, John M (author)

Dobson, Richard J (author)

Howard, Philip J (author)

Mein, Charles A (author)

Onipinla, Abiodun (author)

Shaw-Hawkins, Sue (author)

Zhang, Yun (author)

Smith, George Davey (author)

Day, Ian N M (author)

Lawlor, Debbie A (author)

Goodall, Alison H (author): Karolinska Institutet

Fowkes, F Gerald (author)

Abecasis, Gonçalo R (author)

Elliott, Paul (author)

Gateva, Vesela (author)

Braund, Peter S (author)

Burton, Paul R (author)

Nelson, Christopher P (author)

Tobin, Martin D (author)

van der Harst, Pim (author)

Glorioso, Nicola (author)

Neuvrith, Hani (author)

Salvi, Erika (author)

Staessen, Jan A (author)

Stucchi, Andrea (author)

Devos, Nabila (author)

Jeunemaitre, Xavier (author)

Plouin, Pierre-François (author)

Tichet, Jean (author)

Juhanson, Peeter (author)

Org, Elin (author)

Putku, Margus (author)

Sõber, Siim (author)

Veldre, Gudrun (author)

Viigimaa, Margus (author)

Levinsson, Anna (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine

Rosengren, Annika, 1951 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine

Thelle, Dag, 1942 (author)

Hastie, Claire E (author)

Hedner, Thomas, 1949 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine

Lee, Wai K (author)

Melander, Olle (author): Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups

Wahlstrand, Björn, 1970 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine

Hardy, Rebecca (author)

Wong, Andrew (author)

Cooper, Jackie A (author)

Palmen, Jutta (author)

Chen, Li (author)

Stewart, Alexandre F R (author)

Wells, George A (author)

Westra, Harm-Jan (author)

Wolfs, Marcel G M (author)

Clarke, Robert (author)

Franzosi, Maria Grazia (author)

Goel, Anuj (author)

Hamsten, Anders (author)

Lathrop, Mark (author)

Peden, John F (author)

Seedorf, Udo (author)

Watkins, Hugh (author)

Ouwehand, Willem H (author)

Sambrook, Jennifer (author)

Stephens, Jonathan (author)

Casas, Juan-Pablo (author)

Drenos, Fotios (author)

Holmes, Michael V (author)

Kivimaki, Mika (author)

Shah, Sonia (author)

Shah, Tina (author)

Talmud, Philippa J (author)

Whittaker, John (author)

Wallace, Chris (author)

Delles, Christian (author)

Laan, Maris (author)

Kuh, Diana (author)

Humphries, Steve E (author)

Nyberg, Fredrik, 1961 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine

Cusi, Daniele (author)

Roberts, Robert (author)

Newton-Cheh, Christopher (author)

Franke, Lude (author)

Stanton, Alice V (author)

Dominiczak, Anna F (author)

Farrall, Martin (author)

Hingorani, Aroon D (author)

Samani, Nilesh J (author)

Caulfield, Mark J (author)

Munroe, Patricia B (author)

Laan, Mans (author)

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(creator_code:org_t)

Elsevier BV, 2011
2011
English.
In: American Journal of Human Genetics. - : Elsevier BV. - 1537-6605 .- 0002-9297. ; 89:6

Related links:: http://www.cell.com/...; show more...; http://dx.doi.org/10...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://lup.lub.lu.s...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56 × 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56 × 10(-7) at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.

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By the author/editor: Johnson, Toby; Gaunt, Tom R; Newhouse, Stephe ...; Padmanabhan, San ...; Tomaszewski, Mac ...; Kumari, Meena; show more...; Morris, Richard ...; Tzoulaki, Ioanna; O'Brien, Eoin T; Poulter, Neil R; Sever, Peter; Shields, Denis C; Thom, Simon; Wannamethee, Sas ...; Whincup, Peter H; Brown, Morris J; Connell, John M; Dobson, Richard ...; Howard, Philip J; Mein, Charles A; Onipinla, Abiodu ...; Shaw-Hawkins, Su ...; Zhang, Yun; Smith, George Da ...; Day, Ian N M; Lawlor, Debbie A; Goodall, Alison ...; Fowkes, F Gerald; Abecasis, Gonçal ...; Elliott, Paul; Gateva, Vesela; Braund, Peter S; Burton, Paul R; Nelson, Christop ...; Tobin, Martin D; van der Harst, P ...; Glorioso, Nicola; Neuvrith, Hani; Salvi, Erika; Staessen, Jan A; Stucchi, Andrea; Devos, Nabila; Jeunemaitre, Xav ...; Plouin, Pierre-F ...; Tichet, Jean; Juhanson, Peeter; Org, Elin; Putku, Margus; Sõber, Siim; Veldre, Gudrun; Viigimaa, Margus; Levinsson, Anna; Rosengren, Annik ...; Thelle, Dag, 194 ...; Hastie, Claire E; Hedner, Thomas, ...; Lee, Wai K; Melander, Olle; Wahlstrand, Björ ...; Hardy, Rebecca; Wong, Andrew; Cooper, Jackie A; Palmen, Jutta; Chen, Li; Stewart, Alexand ...; Wells, George A; Westra, Harm-Jan; Wolfs, Marcel G ...; Clarke, Robert; Franzosi, Maria ...; Goel, Anuj; Hamsten, Anders; Lathrop, Mark; Peden, John F; Seedorf, Udo; Watkins, Hugh; Ouwehand, Willem ...; Sambrook, Jennif ...; Stephens, Jonath ...; Casas, Juan-Pabl ...; Drenos, Fotios; Holmes, Michael ...; Kivimaki, Mika; Shah, Sonia; Shah, Tina; Talmud, Philippa ...; Whittaker, John; Wallace, Chris; Delles, Christia ...; Laan, Maris; Kuh, Diana; Humphries, Steve ...; Nyberg, Fredrik, ...; Cusi, Daniele; Roberts, Robert; Newton-Cheh, Chr ...; Franke, Lude; Stanton, Alice V; Dominiczak, Anna ...; Farrall, Martin; Hingorani, Aroon ...; Samani, Nilesh J; Caulfield, Mark ...; Munroe, Patricia ...; Laan, Mans; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: American Journal ...

By the university: University of Gothenburg; Lund University; Karolinska Institutet

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Blood Pressure Loci Identified with a Gene-Centric Array.

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