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Sökning: WFRF:(Osipov E)

  • Resultat 1-10 av 14
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1.
  • Han, L. K. M., et al. (författare)
  • Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
  • 2020
  • Ingår i: Molecular Psychiatry. - 1359-4184 .- 1476-5578.
  • Tidskriftsartikel (refereegranskat)abstract
    • Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. © 2020, The Author(s).
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2.
  • Sanchez-Gonzalez, A., et al. (författare)
  • Auger electron and photoabsorption spectra of glycine in the vicinity of the oxygen K-edge measured with an X-FEL
  • 2015
  • Ingår i: Journal of Physics B-Atomic Molecular and Optical Physics. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 48:23
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the first measurement of the near oxygen K-edge auger spectrum of the glycine molecule. Our work employed an x-ray free electron laser as the photon source operated with input photon energies tunable between 527 and 547 eV. Complete electron spectra were recorded at each photon energy in the tuning range, revealing resonant and non-resonant auger structures. Finally ab initio theoretical predictions are compared with the measured above the edge auger spectrum and an assignment of auger decay channels is performed.
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3.
  • Murphy, B. F., et al. (författare)
  • Femtosecond X-ray-induced explosion of C-60 at extreme intensity
  • 2014
  • Ingår i: Nature Communications. - 2041-1723. ; 5
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding molecular femtosecond dynamics under intense X-ray exposure is critical to progress in biomolecular imaging and matter under extreme conditions. Imaging viruses and proteins at an atomic spatial scale and on the time scale of atomic motion requires rigorous, quantitative understanding of dynamical effects of intense X-ray exposure. Here we present an experimental and theoretical study of C-60 molecules interacting with intense X-ray pulses from a free-electron laser, revealing the influence of processes not previously reported. Our work illustrates the successful use of classical mechanics to describe all moving particles in C-60, an approach that scales well to larger systems, for example, biomolecules. Comparisons of the model with experimental data on C-60 ion fragmentation show excellent agreement under a variety of laser conditions. The results indicate that this modelling is applicable for X-ray interactions with any extended system, even at higher X-ray dose rates expected with future light sources.
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5.
  • Zhaunerchyk, Vitali, et al. (författare)
  • Disentangling formation of multiple-core holes in aminophenol molecules exposed to bright X-FEL radiation
  • 2015
  • Ingår i: ; 48:24
  • Tidskriftsartikel (refereegranskat)abstract
    • Competing multi-photon ionization processes, some leading to the formation of double core hole states, have been examined in 4-aminophenol. The experiments used the linac coherent light source (LCLS) x-ray free electron laser, in combination with a time-of-flight magnetic bottle electron spectrometer and the correlation analysis method of covariance mapping. The results imply that 4-aminophenol molecules exposed to the focused x-ray pulses of the LCLS sequentially absorb more than two x-ray photons, resulting in the formation of multiple core holes as well as in the sequential removal of photoelectrons and Auger electrons (so-called PAPA sequences).
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6.
  • Bielecki, Johan, 1982, et al. (författare)
  • Electrospray sample injection for single-particle imaging with x-ray lasers
  • 2019
  • Ingår i: Science advances. - : American Association for the Advancement of Science. - 2375-2548. ; 5:5
  • Tidskriftsartikel (refereegranskat)abstract
    • The possibility of imaging single proteins constitutes an exciting challenge for x-ray lasers. Despite encouraging results on large particles, imaging small particles has proven to be difficult for two reasons: not quite high enough pulse intensity from currently available x-ray lasers and, as we demonstrate here, contamination of the aerosolized molecules by nonvolatile contaminants in the solution. The amount of contamination on the sample depends on the initial droplet size during aerosolization. Here, we show that, with our electrospray injector, we can decrease the size of aerosol droplets and demonstrate virtually contaminant-free sample delivery of organelles, small virions, and proteins. The results presented here, together with the increased performance of next-generation x-ray lasers, constitute an important stepping stone toward the ultimate goal of protein structure determination from imaging at room temperature and high temporal resolution.
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7.
  • Bolognesi, P., et al. (författare)
  • A study of the dynamical energy flow in uracil
  • 2015
  • Ingår i: Journal of Physics, Conference Series. - 1742-6588 .- 1742-6596. ; 635
  • Tidskriftsartikel (refereegranskat)abstract
    • The time resolved photoionization of C 1s in uracil following excitation of the neutral molecule by 260 nm pulses has been studied at LCLS.
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8.
  • Bushlya, V., et al. (författare)
  • Sintering of binderless cubic boron nitride and its modification by β-Si3N4 additive for hard machining applications
  • 2020
  • Ingår i: International Journal of Refractory Metals and Hard Materials. - : Elsevier. - 0263-4368. ; 86
  • Tidskriftsartikel (refereegranskat)abstract
    • This study present the results of HP-HT sintering, microstructure, properties, and performance of binderless cBN tool material. Within the investigated sintering temperature range of 1900–2600 °C the optimum was found to be 2200–2300 °C. Lower temperature results in incomplete diffusion bonding between cBN grains, while higher temperature results in high degree of recrystallization of initial structure, grain growth, and even formation of hexagonal boron nitride in triple joints. Introduction of stress-inducing β-Si3N4 minor inclusions resulted in high overall mechanical and thermal properties: HK = 41 GPa; KIC = 12.6 MPa·m1/2; λ = 180 W/(m·K). Machining experiments in roughing of hardened tool steels show that binderless cBN material provides high performance in terms of resistance to tool cratering, chipping, and tool fracture.
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9.
  • Fang, L., et al. (författare)
  • Multiple Ionization and Double Core-hole Production in Molecules using the LCLS X-ray FEL
  • 2012
  • Ingår i: Journal of Physics, Conference Series. - 1742-6588 .- 1742-6596. ; 388:3, s. 032028-
  • Tidskriftsartikel (refereegranskat)abstract
    • We used the world's first hard x-ray FEL to investigate the response of molecular systems to the ultra-intense, femtosecond x-ray radiation. We report sequential multiphoton ionization, frustrated absorption and double core hole production mechanisms.
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10.
  • Kleyko, Denis, et al. (författare)
  • Density Encoding Enables Resource-Efficient Randomly Connected Neural Networks
  • 2020
  • Ingår i: IEEE Transactions on Neural Networks and Learning Systems. - : IEEE. - 2162-237X .- 2162-2388.
  • Tidskriftsartikel (refereegranskat)abstract
    • The deployment of machine learning algorithms on resource-constrained edge devices is an important challenge from both theoretical and applied points of view. In this brief, we focus on resource-efficient randomly connected neural networks known as random vector functional link (RVFL) networks since their simple design and extremely fast training time make them very attractive for solving many applied classification tasks. We propose to represent input features via the density-based encoding known in the area of stochastic computing and use the operations of binding and bundling from the area of hyperdimensional computing for obtaining the activations of the hidden neurons. Using a collection of 121 real-world data sets from the UCI machine learning repository, we empirically show that the proposed approach demonstrates higher average accuracy than the conventional RVFL. We also demonstrate that it is possible to represent the readout matrix using only integers in a limited range with minimal loss in the accuracy. In this case, the proposed approach operates only on small n-bits integers, which results in a computationally efficient architecture. Finally, through hardware field-programmable gate array (FPGA) implementations, we show that such an approach consumes approximately 11 times less energy than that of the conventional RVFL.
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