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1.
  • Helgadottir, Anna, et al. (författare)
  • Genome-wide analysis yields new loci associating with aortic valve stenosis
  • 2018
  • Ingår i: Nature Communications. - Nature Publishing Group. - 2041-1723. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR) = 1.20, P = 1.2 × 10-22) and on chromosome 2q22 in TEX41 (rs1830321; OR = 1.15, P = 1.8 × 10-13). Rs7543130 also associates with bicuspid aortic valve (BAV) (OR = 1.28, P = 6.6 × 10-10) and aortic root diameter (P = 1.30 × 10-8), and rs1830321 associates with BAV (OR = 1.12, P = 5.3 × 10-3) and coronary artery disease (OR = 1.05, P = 9.3 × 10-5). The results implicate both cardiac developmental abnormalities and atherosclerosis-like processes in the pathogenesis of AS. We show that several pathways are shared by CAD and AS. Causal analysis suggests that the shared risk factors of Lp(a) and non-high-density lipoprotein cholesterol contribute substantially to the frequent co-occurence of these diseases.
2.
  • Oskarsson, Viktor, et al. (författare)
  • Rising incidence of acute pancreatitis in Sweden : national estimates and trends between 1990 and 2013
  • 2020
  • Ingår i: United European Gastroenterology journal. - Sage Publications. - 2050-6406 .- 2050-6414. ; 8:4, s. 472-480
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background: Recent reports from western countries have indicated an increased incidence and a decreased mortality in acute pancreatitis. However, the incidence assessment has often been hampered by the inclusion of both first-time and recurrent episodes of acute pancreatitis.</p><p>Methods: In this retrospective cohort study, all Swedish residents hospitalized with a first-time episode of acute pancreatitis between 1990 and 2013 were identified using national registers. Sex- and age-standardized incidence rates per 100,000 individuals and year were calculated, as were annual percent changes (APC) from joinpoint regression models.</p><p>Results: Overall, between 1990 and 2013, 66,131 individuals had a first-time episode of acute pancreatitis in Sweden. Comparing the first five years (1990-1994) to the last four years (2010-2013) of the study period, the overall incidence of acute pancreatitis increased from 25.2 (95% confidence interval (CI): 24.1, 26.3) to 38.3 (95% CI: 37.0, 39.5) cases per 100,000 individuals and year. An increase in incidence was observed irrespective of the subtypes of acute pancreatitis as well as the sex and age of the patients. Although the incidence of complicated acute pancreatitis declined in both men and women between 1990 and 2004, it started to increase in both sexes (APC 3.0; 95% CI: 0.5, 5.5 in men; APC 5.4; 95% CI: 2.6, 8.2 in women) from 2005 onwards.</p><p>Conclusion: Based on nationwide data, the incidence of first-time acute pancreatitis has increased in Sweden over a period of 24 years. The incidence of disease-related complications has also been on the rise during the past few years, after declining for more than 15 years before that.</p>
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3.
  • Oskarsson, Viktor, et al. (författare)
  • Rising incidence of acute pancreatitis in Sweden : National estimates and trends between 1990 and 2013.
  • 2020
  • Ingår i: United European Gastroenterology journal. - 2050-6406 .- 2050-6414. ; 8:4, s. 472-480
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>BACKGROUND:</strong> Recent reports from western countries have indicated an increased incidence and a decreased mortality in acute pancreatitis. However, the incidence assessment has often been hampered by the inclusion of both first-time and recurrent episodes of acute pancreatitis.</p><p><strong>METHODS:</strong> In this retrospective cohort study, all Swedish residents hospitalized with a first-time episode of acute pancreatitis between 1990 and 2013 were identified using national registers. Sex- and age-standardized incidence rates per 100,000 individuals and year were calculated, as were annual percent changes (APC) from joinpoint regression models.</p><p><strong>RESULTS:</strong> Overall, between 1990 and 2013, 66,131 individuals had a first-time episode of acute pancreatitis in Sweden. Comparing the first five years (1990-1994) to the last four years (2010-2013) of the study period, the overall incidence of acute pancreatitis increased from 25.2 (95% confidence interval (CI): 24.1, 26.3) to 38.3 (95% CI: 37.0, 39.5) cases per 100,000 individuals and year. An increase in incidence was observed irrespective of the subtypes of acute pancreatitis as well as the sex and age of the patients. Although the incidence of complicated acute pancreatitis declined in both men and women between 1990 and 2004, it started to increase in both sexes (APC 3.0; 95% CI: 0.5, 5.5 in men; APC 5.4; 95% CI: 2.6, 8.2 in women) from 2005 onwards.</p><p><strong>CONCLUSION:</strong> Based on nationwide data, the incidence of first-time acute pancreatitis has increased in Sweden over a period of 24 years. The incidence of disease-related complications has also been on the rise during the past few years, after declining for more than 15 years before that.</p>
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5.
  • Sandin, P, et al. (författare)
  • Precautionary defaults - A new strategy for chemical risk management
  • 2004
  • Ingår i: HUMAN AND ECOLOGICAL RISK ASSESSMENT. - 1080-7039. ; 10:1, s. 1-18
  • Tidskriftsartikel (refereegranskat)abstract
    • In order to give adequate support to risk managers, new risk assessment methods should be developed that are (1) scientifically sound, (2) simplified, and (3) suited for precautionary risk management. In this Perspective we propose that the notion of a precautionary default can be a useful tool in the development of such methods. A precautionary default is a cautious or pessimistic assumption that is used in the absence of adequate information and that should be replaced when such information is obtained. Furthermore, we point out some promising research areas for the development of such indicators, viz. connections between chemical characteristics such as persistence and effect parameters, monitoring of contaminants in polar regions, monitoring of contaminants in breast milk, application of results from (human) toxicology in ecotoxicology and vice versa, (eco) toxicological test systems that are sensitive to effects on reproduction, and the application of bioinformatic methods to complex data, both in genomic research and in ecotoxicology. We conclude that precautionary decision-making does not require less science, but to the contrary it requires more science and improved communication between scientists and risk managers.
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6.
  • A, Lebedev, et al. (författare)
  • Direct photons in WA98.
  • 2002
  • Ingår i: Nuclear Physics A. - Elsevier. ; 698, s. 135-135
  • Tidskriftsartikel (refereegranskat)
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7.
  • Acharya, S, et al. (författare)
  • ALICE Collaboration
  • 2019
  • Ingår i: XXVIIth International Conference on Ultrarelativistic Nucleus–Nucleus Collisions (Quark Matter 2018). - 0375-9474. ; 982, s. 975-984
  • Konferensbidrag (refereegranskat)
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8.
  • Acharya, S, et al. (författare)
  • Analysis of the apparent nuclear modification in peripheral Pb–Pb collisions at 5.02 TeV
  • 2019
  • Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - Elsevier. - 0370-2693. ; 793, s. 420-432
  • Tidskriftsartikel (refereegranskat)abstract
    • Charged-particle spectra at midrapidity are measured in Pb–Pb collisions at the centre-of-mass energy per nucleon–nucleon pair s NN =5.02 TeV and presented in centrality classes ranging from most central (0–5%) to most peripheral (95–100%) collisions. Possible medium effects are quantified using the nuclear modification factor (R AA ) by comparing the measured spectra with those from proton–proton collisions, scaled by the number of independent nucleon–nucleon collisions obtained from a Glauber model. At large transverse momenta (8<p T <20GeV/c), the average R AA is found to increase from about 0.15 in 0–5% central to a maximum value of about 0.8 in 75–85% peripheral collisions, beyond which it falls off strongly to below 0.2 for the most peripheral collisions. Furthermore, R AA initially exhibits a positive slope as a function of p T in the 8–20 GeV/c interval, while for collisions beyond the 80% class the slope is negative. To reduce uncertainties related to event selection and normalization, we also provide the ratio of R AA in adjacent centrality intervals. Our results in peripheral collisions are consistent with a PYTHIA-based model without nuclear modification, demonstrating that biases caused by the event selection and collision geometry can lead to the apparent suppression in peripheral collisions. This explains the unintuitive observation that R AA is below unity in peripheral Pb–Pb, but equal to unity in minimum-bias p–Pb collisions despite similar charged-particle multiplicities. © 2019 Conseil Européen pour la Recherche Nucléaire
9.
  • Acharya, S, et al. (författare)
  • Anisotropic flow in Xe–Xe collisions at sNN=5.44 TeV
  • 2018
  • Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - Elsevier. - 0370-2693. ; 784, s. 82-95
  • Tidskriftsartikel (refereegranskat)abstract
    • The first measurements of anisotropic flow coefficients vn for mid-rapidity charged particles in Xe–Xe collisions at sNN=5.44 TeV are presented. Comparing these measurements to those from Pb–Pb collisions at sNN=5.02 TeV, v2 is found to be suppressed for mid-central collisions at the same centrality, and enhanced for central collisions. The values of v3 are generally larger in Xe–Xe than in Pb–Pb at a given centrality. These observations are consistent with expectations from hydrodynamic predictions. When both v2 and v3 are divided by their corresponding eccentricities for a variety of initial state models, they generally scale with transverse density when comparing Xe–Xe and Pb–Pb, with some deviations observed in central Xe–Xe and Pb–Pb collisions. These results assist in placing strong constraints on both the initial state geometry and medium response for relativistic heavy-ion collisions. © 2018 European Organization for Nuclear Research
10.
  • Acharya, S, et al. (författare)
  • Anisotropic flow of identified particles in Pb-Pb collisions at √sNN=5.02 TeV
  • 2018
  • Ingår i: Journal of High Energy Physics. - Springer. - 1029-8479. ; 2018:9
  • Tidskriftsartikel (refereegranskat)abstract
    • The elliptic (v2), triangular (v3), and quadrangular (v4) flow coefficients of π±, K±, p+p¯,Λ+Λ¯,KS0, and the ϕ-meson are measured in Pb-Pb collisions at sNN=5.02 TeV. Results obtained with the scalar product method are reported for the rapidity range |y| < 0.5 as a function of transverse momentum, pT, at different collision centrality intervals between 0–70%, including ultra-central (0–1%) collisions for π±, K±, and p + p ¯. For pT< 3 GeV/c, the flow coefficients exhibit a particle mass dependence. At intermediate transverse momenta (3 < pT < 8–10 GeV/c), particles show an approximate grouping according to their type (i.e., mesons and baryons). The ϕ-meson v2, which tests both particle mass dependence and type scaling, follows p + p ¯ v2 at low pT and π±v2 at intermediate pT. The evolution of the shape of vn(pT) as a function of centrality and harmonic number n is studied for the various particle species. Flow coefficients of π±, K±, and p + p ¯ for pT < 3 GeV/c are compared to iEBE-VISHNU and MUSIC hydrodynamical calculations coupled to a hadronic cascade model (UrQMD). The iEBE-VISHNU calculations describe the results fairly well for pT < 2.5 GeV/c, while MUSIC calculations reproduce the measurements for pT < 1 GeV/c. A comparison to vn coefficients measured in Pb-Pb collisions at sNN=2.76 TeV is also provided.[Figure not available: see fulltext.]. © 2018, The Author(s).
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