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Untargeted screenin...
Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis
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- Zandian, Arash (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Affin Prote, SciLifeLab, Tomtebodavagen 23A, S-17165 Stockholm, Sweden.
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- Wingård, L. (författare)
- Karolinska Institutet,Karolinska Inst, Ctr Mol Med, Karolinska Univ Hosp Solna, Dept Clin Neurosci, L8 01, Stockholm, Sweden.;Karolinska Univ Hosp Solna, SLSO, Psykiatri Nordvast, Stockholm, Sweden.;Karolinska Inst, Karolinska Univ Hosp Solna, Ctr Pharmacoepidemiol, Dept Med, Stockholm, Sweden.
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- Nilsson, H. (författare)
- Karolinska Inst, Ctr Mol Med, Karolinska Univ Hosp Solna, Dept Clin Neurosci, L8 01, Stockholm, Sweden.
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- Sjöstedt, Evelina (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi
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- Johansson, D. X. (författare)
- Karolinska Inst, Ctr Mol Med, Karolinska Univ Hosp Solna, Dept Clin Neurosci, L8 01, Stockholm, Sweden.
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- Just, David (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Affin Prote, SciLifeLab, Tomtebodavagen 23A, S-17165 Stockholm, Sweden.
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- Hellström, Cecilia (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Affin Prote, SciLifeLab, Tomtebodavagen 23A, S-17165 Stockholm, Sweden.
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- Uhlén, Mathias (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Affin Prote, SciLifeLab, Tomtebodavagen 23A, S-17165 Stockholm, Sweden.
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- Schwenk, Jochen M. (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Affin Prote, SciLifeLab, Tomtebodavagen 23A, S-17165 Stockholm, Sweden.
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- Häggmark-Månberg, Anna (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Affin Prote, SciLifeLab, Tomtebodavagen 23A, S-17165 Stockholm, Sweden.
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- Norbeck, O. (författare)
- Karolinska Inst, Karolinska Univ Hosp Solna, Ctr Mol Med, Dept Med, L8 01, Stockholm, Sweden.;Karolinska Inst, Sect Psychiat, Karolinska Univ Hosp Huddinge, Dept Clin Neurosci,Ctr Psychiat Res, Stockholm, Sweden.
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- Owe-Larsson, B. (författare)
- Karolinska Institutet,Karolinska Inst, Sect Psychiat, Karolinska Univ Hosp Huddinge, Dept Clin Neurosci,Ctr Psychiat Res, Stockholm, Sweden.
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- Nilsson, Peter (författare)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sch Biotechnol, Affin Prote, SciLifeLab, Tomtebodavagen 23A, S-17165 Stockholm, Sweden.
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- Persson, M. A. A. (författare)
- Karolinska Institutet,Karolinska Inst, Ctr Mol Med, Karolinska Univ Hosp Solna, Dept Clin Neurosci, L8 01, Stockholm, Sweden.;Karolinska Univ Hosp Solna, SLSO, Psykiatri Nordvast, Stockholm, Sweden.
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(creator_code:org_t)
- 2017-07-25
- 2017
- Engelska.
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Ingår i: Translational Psychiatry. - : Nature Publishing Group. - 2158-3188. ; 7
- Relaterad länk:
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Immunological and inflammatory reactions have been suggested to have a role in the development of schizophrenia, a hypothesis that has recently been supported by genetic data. The aim of our study was to perform an unbiased search for autoantibodies in patients with a first psychotic episode, and to explore the association between any seroreactivity and the development of a Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) disorder characterized by chronic or relapsing psychotic symptoms. We collected plasma samples from 53 patients when they were treated for their first-episode psychosis, and 41 non-psychotic controls, after which the patients were followed for a mean duration of 7 years. Thirty patients were diagnosed with schizophrenia, delusional disorder, schizoaffective disorder, bipolar disorder or a long-term unspecified nonorganic psychosis during follow-up, whereas 23 patients achieved complete remission. At the end of follow-up, plasma samples were analyzed for IgG reactivity to 2304 fragments of human proteins using a multiplexed affinity proteomic technique. Eight patient samples showed autoreactivity to the N-terminal fragment of the PAGE (P antigen) protein family (PAGE2B/PAGE2/PAGE5), whereas no such autoreactivity was seen among the controls. PAGE autoreactivity was associated with a significantly increased risk of being diagnosed with schizophrenia during follow-up (odds ratio 6.7, relative risk 4.6). An immunohistochemistry analysis using antisera raised against the N-terminal fragment stained an unknown extracellular target in human cortical brain tissue. Our findings suggest that autoreactivity to the N-terminal portion of the PAGE protein family is associated with schizophrenia in a subset of patients with first-episode psychosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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Zandian, Arash
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Wingård, L.
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Nilsson, H.
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Sjöstedt, Evelin ...
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Johansson, D. X.
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Just, David
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visa fler...
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Hellström, Cecil ...
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Uhlén, Mathias
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Schwenk, Jochen ...
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Häggmark-Månberg ...
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Norbeck, O.
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Owe-Larsson, B.
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Nilsson, Peter
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Persson, M. A. A ...
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