SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(PALMBLAD J) "

Sökning: WFRF:(PALMBLAD J)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Bergemalm, D., et al. (författare)
  • Platelet proteome and function in X-linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome
  • 2020
  • Ingår i: Haematologica. - : Ferrata Storti Foundation. - 1592-8721 .- 0390-6078.
  • Tidskriftsartikel (refereegranskat)abstract
    • In X-linked thrombocytopenia with thalassemia (XLTT; OMIM 314050), caused by the mutation p.R216Q in exon 4 of the GATA1 gene, male hemizygous patients display macrothrombocytopenia, bleeding diathesis and a β-thalassemia trait. Herein, we describe findings in two unrelated Swedish XLTT families with a bleeding tendency exceeding what is expected from the thrombocytopenia. Blood tests revealed low P-PAI-1 and P-factor 5, and elevated S-thrombopoietin levels. Transmission electron microscopy showed diminished numbers of platelet α- and dense granules. The proteomes of isolated blood platelets from 5 male XLTT patients, compared to 5 gender- and age matched controls, were explored. Quantitative mass spectrometry showed alterations of 83 proteins (fold change ≥±1.2, q< .05). Of 46 downregulated proteins, 39 were previously reported to be associated with platelet granules. Reduced protein levels of PTGS1 and SLC35D3 were validated in megakaryocytes of XLTT bone marrow biopsies by immunohistochemistry. Platelet function testing by flow cytometry revealed low dense- and α-granule release and fibrinogen binding in response to ligation of receptors for ADP, the thrombin receptor PAR4 and the collagen receptor GPVI. Significant reductions of a number of α-granule proteins overlapped with a previous platelet proteomics investigation in the inherited macrothrombocytopenia gray platelet syndrome (GPS). In contrast, Ca2+ transporter proteins that facilitate dense granule release were downregulated in XLTT but upregulated in GPS. Ingenuity Pathway Analysis showed altered Coagulation System and Protein Ubiquitination pathways in the XLTT platelets. Collectively, the results revealed protein and functional alterations affecting platelet α- and dense granules in XLTT, probably contributing to bleeding.
  •  
2.
  •  
3.
  • Palmblad, Jan, et al. (författare)
  • TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders
  • 2008
  • Ingår i: International Journal of Medical Sciences. - Lake Haven : Ivyspring international publishers. - 1449-1907 .- 1449-1907. ; 5:2, s. 87-91
  • Tidskriftsartikel (refereegranskat)abstract
    • Anagrelide is often used in the treatment of thrombocythemia in myeloproliferative disease (MPD), but information concerning effects of treatment on cytokines involved in regulation of blood platelet levels is limited. Here, we investigated serum levels of thrombopoietin (TPO) and soluble IL-6 receptor (sIL-6R) in relation to response to treatment with and plasma concentrations of anagrelide. Samples from 45 patients with thrombocythemia due to MPD (ET=31, PV=14), being treated with anagrelide for 6 months, were analyzed for TPO, sIL-6R and anagrelide levels. The mean baseline platelet count was 983x10(9)/L. A reduction of platelets to <600 in asymptomatic or <400 x 10(9)/L in symptomatic patients was defined as a complete remission (CR), a reduction with >50% of baseline as partial remission, and <50% reduction as failure. At 6 months, 35 patients were in CR, 1 had a partial remission and 9 were treatment failures. For all patients, there was an increase in TPO of 44% from baseline; this change was more pronounced for patients with partial remission and failure. sIL-6R levels did not change significantly. There was no correlation between levels of anagrelide and cytokine levels at 6 months, and changes of cytokine levels did not relate to changes of platelet counts. Thus, a pronounced increase of TPO levels after 6 months of anagrelide treatment indicated that this treatment affected a major regulatory mechanism for megakaryocyte and platelet formation in MPD.
  •  
4.
  •  
5.
  •  
6.
  • Berntorp, Erik, et al. (författare)
  • Treatment of haemophilia A and B and von Willebrand's disease: summary and conclusions of a systematic review as part of a Swedish health-technology assessment.
  • 2012
  • Ingår i: Haemophilia. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 1351-8216 .- 1365-2516. ; 18:2, s. 158-165
  • Tidskriftsartikel (refereegranskat)abstract
    • Summary. In an ongoing health-technology assessment of haemophilia treatment in Sweden, performed by the governmental agency Dental and Pharmaceutical Benefits Agency (TLV; tandva˚rds-och lākemedelsförma˚nsverket), the Swedish Council on Health Technology Assessment (SBU; statens beredning för medicinsk utvārdering) was called upon to evaluate treatment of haemophilia A and B and von Willebrand's disease (VWD) with clotting factor concentrates. To evaluate the following questions: What are the short-term and long-term effects of different treatment strategies? What methods are available to treat haemophilia patients that have developed inhibitors against factor concentrates? Based on the questions addressed by the project, a systematic database search was conducted in PubMed, NHSEED, Cochrane Library, EMBASE and other relevant databases. The literature search covered all studies in the field published from 1985 up to the spring of 2010. In most instances, the scientific evidence is insufficient for the questions raised in the review. Concentrates of coagulation factors have good haemostatic effects on acute bleeding and surgical intervention in haemophilia A and B and VWD, but conclusions cannot be drawn about possible differences in the effects of different dosing strategies for acute bleeding and surgery. Prophylaxis initiated at a young age can prevent future joint damage in persons with haemophilia. The available treatment options for inhibitors have been insufficiently assessed. The economic consequences of various treatment regimens have been insufficiently analysed. Introduction of national and international registries is important.
  •  
7.
  •  
8.
  • Carlsson, G, et al. (författare)
  • Hematopoietic stem cell transplantation in severe congenital neutropenia
  • 2011
  • Ingår i: Pediatric Blood & Cancer. - 1545-5009 .- 1545-5017. ; 56:3, s. 444-451
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND:Severe congenital neutropenia (SCN) is an immunodeficiency characterized by disturbed myelopoiesis and an absolute neutrophil count (ANC) <0.5 × 10(9)/L. SCN is also a premalignant condition; a significant proportion of patients develop myelodysplastic syndrome or leukemia (MDS/L). Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCN.PROCEDURE:Since 2004, eight HSCT have been performed in seven patients at our center. The indications were transformation to MDS/L (n = 2), granulocyte colony-stimulating factor receptor (CSF3R) mutation(s) (n = 2), granulocyte colony-stimulating factor (G-CSF) resistance (n = 2), and at the patient's own request (n = 1).RESULTS:The mean age at transplantation was 13 years (2.8-28 years) (mean follow-up 32 months, range 21-60). Three patients harbored ELANE mutations, three HAX1 mutations, and in one patient no causative mutation was identified. Two of the ELANE mutations were novel mutations. Three patients initially received myeloablative conditioning and four had reduced intensity conditioning (RIC). Three grafts were from HLA-identical siblings, three from matched unrelated donors and two were cord blood units. Engraftment occurred in all patients. Two of seven (29%) patients died; both had MDS/L and both were among the three that underwent myeloablative conditioning. One patient has chronic GVHD 2 years post-transplant.CONCLUSIONS:The role of HSCT should be explored further in patients with SCN. In particular, the influence of the conditioning regime needs to be evaluated in a larger cohort of patients.
  •  
9.
  •  
10.
  • Cederholm, Tommy, et al. (författare)
  • Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients
  • 2007
  • Ingår i: Journal of Internal Medicine. - 0954-6820 .- 1365-2796. ; 262:2, s. 215-223
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives. We asked if single nucleotide polymorphisms (SNP) in inflammatory cytokine genes related to 3-year survival in ill elderly subjects and if genotypes differed between the elderly and a younger control population. Design. Prospective observational study. Setting. Two geriatric departments at a university hospital. Subjects. Eighty three acutely admitted geriatric patients (83 ± 7 year, 70% women) and 207 young healthy subjects (40 ± 1 year, 37% women) were included. Outcome measures. Single nucleotide polymorphisms in the genes of tumour necrosis factor (TNF)-α–308 G/A, interleukin (IL)-1β–511 C/T, IL-6–174 G/C and IL-10–1082 A/G were analysed. In the geriatric patients SNP in lymphotoxin (LT)-α +252 G/A and serum levels of TNF-α, IL-6, IL-10, soluble IL-I receptor(R)II were also determined, as well as the 3-year mortality. Results. The allele distribution did not differ significantly between the elderly and the young. In the female elderly, 3-year survival was doubled (P < 0.05) in those with the high-producing genotypes of IL-6 –174 GG and TNF-α -308 GA compared with those with low-producing alleles. In contrast, men with high-producing LT-α +252 AA and IL-1β–511 CT&TT genotypes displayed halved 3-year survival (P < 0.05) compared with those with low-producing genotypes, whereas possession of the high-producing IL-10 –1082 GG genotype favoured survival. Serum IL-10 was higher in the high-producing IL-10 genotype in females. Conclusion. As high-producing IL-6 –174 genotype favoured 3-year survival in women, whereas the likewise high-producing LT-α +252 and IL-1β -511 genotypes were associated with poor survival in men, we conclude that the specific genotypes, in association with gender, may act as determinants for survival in elderly patients.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (205)
konferensbidrag (50)
forskningsöversikt (4)
bokkapitel (1)
annan publikation (1)
Typ av innehåll
refereegranskat (191)
övrigt vetenskapligt (70)
Författare/redaktör
Palmblad, J (234)
Cederholm, T (46)
Palmblad, Jan (37)
Vedin, I (29)
Cederholm, Tommy (24)
Carlsson, G. (22)
visa fler...
Fadeel, B (22)
Basun, H (22)
Wahlund, LO (21)
Freund-Levi, Y (19)
Palmblad, M (18)
Freund-Levi, Yvonne, ... (18)
Henter, JI (17)
Vedin, Inger (16)
Johansson, AS (16)
Basun, Hans (15)
Wahlund, Lars-Olof (15)
Hjorth, E (15)
Zetterberg, E (14)
Bratt, J (14)
Schultzberg, M (13)
Faxén Irving, Gerd (13)
Samuelsson, J (12)
Palmblad, K (12)
Mints, M (12)
Ahlin, A (12)
Merup, M. (11)
Andersson, P (11)
Eriksdotter, M (11)
LERNER, R (11)
Hjorth, Erik (11)
Nordenskjold, M (10)
Fadeel, Bengt (10)
Faxen-Irving, G (10)
Irving, GF (10)
Andersson, U (9)
Bjorkholm, M (9)
Schultzberg, Mariann ... (9)
Bergquist, J. (8)
Haeggstrom, JZ (8)
Heimburger, M (8)
Dale, DC (8)
Eriksdotter, Maria (8)
Papadaki, HA (8)
Vessby, B (7)
Gyllenhammar, H (7)
Tesfa, D (7)
Blomgren, B (7)
Eriksdotter-Jönhagen ... (7)
Rogers, R. (7)
visa färre...
Lärosäte
Karolinska Institutet (226)
Uppsala universitet (52)
Örebro universitet (24)
Lunds universitet (6)
Linköpings universitet (4)
Kungliga Tekniska Högskolan (3)
visa fler...
Göteborgs universitet (2)
Umeå universitet (2)
visa färre...
Språk
Engelska (259)
Svenska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (40)
Naturvetenskap (7)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy