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Association of a pr...
Association of a protective paraoxonase 1 (PON1) polymorphism in Parkinson's disease
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- Ahmadi, Ahmad (author)
- Linköpings universitet,Karolinska Institutet,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden,Hälsouniversitetet,Cellbiologi
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- Ran, C. (author)
- Karolinska Institutet,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Anvret, A. (author)
- Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
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- Paddock, S. (author)
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Westerlund, M. (author)
- Karolinska Institutet,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Håkansson, Anna, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, Sahlgrenska Academy at Göteborg University, Sweden
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- Nissbrandt, Hans, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, Sahlgrenska Academy at Göteborg University, Sweden
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- Söderkvist, Peter (author)
- Linköpings universitet,Hälsouniversitetet,Cellbiologi
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- Dizdar (Dizdar Segrell), Nil, 1960- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Neurologiska kliniken
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Ahmadi, A. (author)
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Anvret, M. (author)
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- Willows, T. (author)
- Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
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- Sydow, O. (author)
- Karolinska Institutet,Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
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- Galter, D. (author)
- Karolinska Institutet,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Neuroscience Letters. - : Elsevier BV. - 0304-3940 .- 1872-7972. ; 522:1, s. 30-35
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Abstract
Subject headings
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- Pesticide exposure has been suggested to increase the risk to develop Parkinson's disease (PD). The arylesterase paraoxonase 1 (PON1) is mainly expressed in the liver and hydrolyzes organophosphates such as pesticides. The polymorphism Leu54Met (rs854560) in PON1, impairing enzyme activity and leading to decreased PON1 expression levels, has been reported to be associated with Parkinson's disease (PD). PON1 is part of a cluster on chromosome 7q21.3 together with PON2 and PON3. We investigated the occurrence of four additional polymorphisms in PON1 and two in PON2 in a Swedish PD case-control material. We found a significant association (p = 0.007) with a PON1 promoter polymorphism, rs854571. The minor allele was more common among controls than PD cases which suggest a protective effect. This is strengthened by the fact that rs854571 is in strong linkage disequilibrium with another PON1 promoter polymorphism, rs854572, reported to increase PON1 gene expression. Our findings support the hypothesis that PON1 is involved in the etiology of PD and that higher PON1 levels are reducing the risk for PD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Pesticide
- Linkage disequilibrium
- Lipid peroxidation
- serum concentrations
- alzheimer-disease
- gene
- population
- oxidation
- exposure
- promoter
- allele
- risk
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ahmadi, Ahmad
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Ran, C.
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Anvret, A.
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Paddock, S.
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Westerlund, M.
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Håkansson, Anna, ...
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Nissbrandt, Hans ...
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Söderkvist, Pete ...
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Dizdar (Dizdar S ...
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Ahmadi, A.
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Anvret, M.
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Willows, T.
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Sydow, O.
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Galter, D.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Neuroscience Let ...
- By the university
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University of Gothenburg
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Karolinska Institutet
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Linköping University