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An international in...
An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
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- Lucidarme, J. (författare)
- Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom
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- Scott, K. J. (författare)
- Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom
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- Ure, R. (författare)
- Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom
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- Smith, A. (författare)
- Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom; College of Medical, Veterinary & Life Sciences, Glasgow Dental Hospital & School, University of Glasgow, Glasgow, United Kingdom
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- Lindsay, D. (författare)
- Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom
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- Stenmark, Bianca, 1987- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
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- Jacobsson, Susanne, 1974- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
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- Fredlund, Hans, 1952- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
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- Cameron, J. C. (författare)
- Health Protection Scotland, NHS National Services Scotland, Glasgow, United Kingdom
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- Smith-Palmer, A. (författare)
- Health Protection Scotland, NHS National Services Scotland, Glasgow, United Kingdom
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- McMenamin, J. (författare)
- Health Protection Scotland, NHS National Services Scotland, Glasgow, United Kingdom
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- Gray, S. J. (författare)
- Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom
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- Campbell, H. (författare)
- Immunisation Department, Public Health England, London, United Kingdom
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- Ladhani, S. (författare)
- Immunisation Department, Public Health England, London, United Kingdom
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- Findlow, J. (författare)
- Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom
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- Mölling, Paula (författare)
- National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Borrow, R. (författare)
- Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom
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(creator_code:org_t)
- Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC), 2016
- 2016
- Engelska.
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Ingår i: Eurosurveillance. - Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC). - 1025-496X .- 1560-7917. ; 21:45, s. 15-23
- Relaterad länk:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- The 23rd World Scout Jamboree in 2015 took place in Japan and included over 33,000 scouts from 162 countries. Within nine days of the meeting ending, six cases of laboratory-confirmed invasive serogroup W meningococcal disease occurred among scouts and their close contacts in Scotland and Sweden. The isolates responsible were identical to one-another by routine typing and, where known (4 isolates), belonged to the ST-11 clonal complex (cc11) which is associated with large outbreaks and high case fatality rates. Recent studies have demonstrated the need for high-resolution genomic typing schemes to assign serogroup W cc11 isolates to several distinct strains circulating globally over the past two decades. Here we used such schemes to confirm that the Jamboree-associated cases constituted a genuine outbreak and that this was due to a novel and rapidly expanding strain descended from the strain that has recently expanded in South America and the United Kingdom. We also identify the genetic differences that define the novel strain including four point mutations and three putative recombination events involving the horizontal exchange of 17, six and two genes, respectively. Noteworthy outcomes of these changes were antigenic shifts and the disruption of a transcriptional regulator.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Infektionssjukdomar
- Infectious Diseases
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- ref (ämneskategori)
- art (ämneskategori)
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Lucidarme, J.
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Scott, K. J.
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Ure, R.
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Smith, A.
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Lindsay, D.
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Stenmark, Bianca ...
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Jacobsson, Susan ...
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Fredlund, Hans, ...
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Cameron, J. C.
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Smith-Palmer, A.
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McMenamin, J.
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Gray, S. J.
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Campbell, H.
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Ladhani, S.
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Findlow, J.
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Mölling, Paula
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Borrow, R.
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