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Sökning: WFRF:(Papathoma Eugenia)

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1.
  • Mantzoros, Christos, et al. (författare)
  • Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns.
  • 2004
  • Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 151:6
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>OBJECTIVE:</strong> To assess serum adiponectin levels of neonates in relation to ponderal index and birth length with and without adjustment for potential confounding factors including maternal factors and perinatal characteristics.</p><p><strong>DESIGN:</strong> A cross-sectional study.</p><p><strong>METHODS:</strong> Three hundred and three newborns (Caucasian, singleton, full term, with a birth weight of &gt; or =2500 g, and apparently healthy) were included in the study. Blood samples were collected from the newborns no later than the fifth day of life for measurements of adiponectin and major IGF system components (IGF-I, IGF-II, IGF binding protein-3 (IGFBP-3)). The data were analyzed using simple and multiple regression analyses.</p><p><strong>RESULTS:</strong> Adiponectin is substantially higher in neonates than in adults, with no evidence of the gender dimorphism observed among adults. We found an inverse association between neonatal adiponectin levels and newborn ponderal index and a positive association with newborn length by univariate analysis. We also found a statistically significant inverse association of adiponectin with jaundice/bilirubin, and a marginally significant positive association of this hormone with IGFBP-3 but no significant association with any maternal factors. In multivariate analysis, the inverse association between serum adiponectin and ponderal index does not remain significant after adjustment for potential confounding factors. In contrast, neonatal adiponectin levels correlate inversely significantly and independently with liver maturity and IGF-II and tend to remain positively associated with IGFBP-3 and increased birth length.</p><p><strong>CONCLUSIONS:</strong> An inverse association of adiponectin with ponderal index by univariate analysis is not independent from confounding factors. In contrast, the positive association between serum adiponectin and birth length may reflect either a direct effect of adiponectin or an adiponectin-mediated increase in the sensitivity of tissues to insulin and components of the IGF system, and needs to be explored further.</p>
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2.
  • Petridou, Eleni, et al. (författare)
  • Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding.
  • 2005
  • Ingår i: Clinical Endocrinology. - 0300-0664 .- 1365-2265. ; 62:3, s. 366-71
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>OBJECTIVE:</strong> To investigate predictors of circulating leptin in healthy full-term newborns and to explore the relationship with anthropometric variables, serum levels of adiponectin and the major components of the IGF system at birth. To explore whether leptin levels are regulated by breastfeeding vs. formula feeding.</p><p><strong>DESIGN:</strong> Observational cross-sectional study.</p><p><strong>PATIENTS:</strong> Three hundred and nineteen healthy full-term newborns delivered during 1999 in Athens, Greece.</p><p><strong>MEASUREMENTS:</strong> Anthropometric measurements, formula feeding information and blood samples were obtained. Leptin and adiponectin determinations were performed using a radioimmunoassay (RIA).</p><p><strong>RESULTS:</strong> Multivariate regression analyses showed that leptin levels were positively associated with female gender, newborn length, ponderal index and IGF-I levels, but not with adiponectin levels. Newborns who were fed exclusively with milk formulas had more than twice the leptin levels of those who were exclusively breastfed.</p><p><strong>CONCLUSIONS:</strong> Leptin levels are positively related to female gender and anthropometric characteristics of neonates but, contrary to studies in adults, are not correlated with adiponectin levels. We also found evidence that formula feeding imparts a considerable increase in leptin levels in newborns.</p>
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