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May P-glycoprotein ...
May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol
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Serra, Massimo (author)
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Pasello, Michela (author)
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Manara, Maria Cristina (author)
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Scotlandi, Katia (author)
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Ferrari, Stefano (author)
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Bertoni, Franco (author)
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Mercuri, Mario (author)
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- Alvegård, Thor (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Picci, Piero (author)
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Bacc, Gaetano (author)
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Smeland, Sigbjorn (author)
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: International Journal of Oncology. - 1019-6439. ; 29:6, s. 1459-1468
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
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- The aim was to evaluate the clinical impact of P-glycoprotein in primary non-metastatic high-grade osteosarcoma patients, treated with neoadjuvant chemotherapy protocols. P-glycoprotein was assessed by immunohistochemistry on paraffin-embedded tissue samples collected at time of diagnosis from 94 osteosarcoma patients, treated with the Italian Sarcoma Group/Scandinavian Sarcoma Group 1 (ISG/SSG 1) protocol. P-glycoprotein-positivity at diagnosis was found in 53/94 ISG/SSG 1 cases (56%) and emerged as the single factor significantly associated with an unfavourable outcome from survival and multivariate analyses. A comparative analysis of the subgroup of 94 patients considered for P-glycoprotein evaluation and the whole series of ISG/SSG 1 patients showed that this marker retained its prognostic value also in the latter group. In osteosarcoma patients treated with doxorubicin-based chemotherapy protocols, P-glycoprotein overexpression at diagnosis is an important adverse prognostic factor for outcome. P-glycoprotein evaluation can therefore constitute the basis for stratifying, at diagnosis, osteosarcoma patients for whom alternative treatments may be considered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- prognosis
- chemotherapy
- drug resistance
- osteosarcoma
- P-glycoprotein
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Serra, Massimo
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Pasello, Michela
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Manara, Maria Cr ...
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Scotlandi, Katia
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Ferrari, Stefano
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Bertoni, Franco
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show more...
-
Mercuri, Mario
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Alvegård, Thor
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Picci, Piero
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Bacc, Gaetano
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Smeland, Sigbjor ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Lund University