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Sökning: WFRF:(Pedersen L) > Annan publikation

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1.
  • Sahin, Cagla, et al. (författare)
  • Structural basis for dityrosine-mediated inhibition of alpha-synuclein fibrillation
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • α-synuclein (aSyn) is a small intrinsically disordered protein which can self-assemble into highly organized β-sheet structures that are found to accumulate in plaques in the brain of Parkinson’s Disease patients. Oxidative stress has been shown to be important for aSyn and its self-assembly. Here we characterize the molecular and structural effects that mild oxidation has on aSyn monomer and its aggregation. Using a combination of biophysical methods, SAXS and native ion mobility mass spectrometry, we find that oxidation leads to formation of intramolecular dityrosine cross-linkages that reduce aSyn’s size by a factor of √2. MD simulations support our experimental results showing a stable and compact aSyn conformation that prevents self-assembly and amyloid formation by steric hindrance, suggesting an important role of mild oxidation in preventing amyloid formation. 
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2.
  • A. Marques, Ana F., et al. (författare)
  • The Seven Sisters Hydrothermal System : First Record of Shallow Hybrid Mineralization Hosted in Mafic Volcaniclasts on the Arctic Mid-Ocean Ridge
  • 2020
  • Ingår i: Minerals. - : MDPI AG. - 2075-163X.
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • We document the discovery of an active, shallow, seafloor hydrothermal system (known as the Seven Sisters Vent Field) hosted in mafic volcaniclasts at a mid-ocean ridge setting. The vent field is located at the southern part of the Arctic mid-ocean ridge where it lies on top of a flat-topped volcano at ~130 m depth. Up to 200 deg C phase-separating fluids vent from summit depressions in the volcano, and from pinnacle-like edifices on top of large hydrothermal mounds. The hydrothermal mineralization at Seven Sisters manifests as a replacement of mafic volcaniclasts, as direct intraclast precipitation from the hydrothermal fluid, and as elemental sulfur deposition within orifices. Barite is ubiquitous, and is sequentially replaced by pyrite, which is the first sulfide to form, followed by Zn-Cu-Pb-Ag bearing sulfides, sulfosalts, and silica. The mineralized rocks at Seven Sisters contain highly anomalous concentrations of ‘epithermal suite’ elements such as Tl, As, Sb and Hg, with secondary alteration assemblages including silica and dickite. Vent fluids have a pH of ~5 and are Ba and metal depleted. Relatively high dissolved Si (~7.6 mmol/L Si) combined with low (0.2–0.4) Fe/Mn suggest high-temperature reactions at ~150 bar. A delta-13C value of -5.4 permil in CO2 dominated fluids denotes magmatic degassing from a relatively undegassed reservoir. Furthermore, low CH4 and H2 (<0.026 mmol/kg and <0.009 mmol/kg, respectively) and 3He/4He of ~8.3 R/Racorr support a MORB-like, sediment-free fluid signature from an upper mantle source. Sulfide and secondary alteration mineralogy, fluid and gas chemistry, as well as delta-34S and 87Sr/86Sr values in barite and pyrite indicate that mineralization at Seven Sisters is sustained by the input of magmatic fluids with minimal seawater contribution. 226Ra/Ba radiometric dating of the barite suggests that this hydrothermal system has been active for at least 4670 +/- 60 yr.
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3.
  • Olsson, AM, et al. (författare)
  • State of the Art - Immpotens
  • 1999
  • Ingår i: Medicinsk Faktabas - MARS. - : Socialstyrelsen.
  • Annan publikation (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-3 av 3

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