Evidence of Inbreeding Depression on Human Height

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: WFRF:(Pehlic M) > Perola Markus > Evidence of Inbreed...

1 of 1
Previous record
Next record
To hitlist

Evidence of Inbreeding Depression on Human Height

McQuillan, Ruth (author)

Eklund, Niina (author)

Pirastu, Nicola (author)

Kuningas, Maris (author)

McEvoy, Brian P (author)

Esko, Tõnu (author)

Corre, Tanguy (author)

Davies, Gail (author)

Kaakinen, Marika (author)

Lyytikäinen, Leo-Pekka (author)

Kristiansson, Kati (author)

Havulinna, Aki S (author)

Gögele, Martin (author)

Vitart, Veronique (author)

Tenesa, Albert (author)

Aulchenko, Yurii (author)

Hayward, Caroline (author)

Johansson, Åsa (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Boban, Mladen (author)

Ulivi, Sheila (author)

Robino, Antonietta (author)

Boraska, Vesna (author)

Igl, Wilmar (author): Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab

Wild, Sarah H (author)

Zgaga, Lina (author)

Amin, Najaf (author)

Theodoratou, Evropi (author)

Polašek, Ozren (author)

Girotto, Giorgia (author)

Lopez, Lorna M (author)

Sala, Cinzia (author)

Lahti, Jari (author)

Laatikainen, Tiina (author)

Prokopenko, Inga (author)

Kals, Mart (author)

Viikari, Jorma (author)

Yang, Jian (author)

Pouta, Anneli (author)

Estrada, Karol (author)

Hofman, Albert (author)

Freimer, Nelson (author)

Martin, Nicholas G (author)

Kähönen, Mika (author)

Milani, Lili (author)

Heliövaara, Markku (author)

Vartiainen, Erkki (author)

Räikkönen, Katri (author)

Masciullo, Corrado (author)

Starr, John M (author)

Hicks, Andrew A (author)

Esposito, Laura (author)

Kolčić, Ivana (author)

Farrington, Susan M (author)

Oostra, Ben (author)

Zemunik, Tatijana (author)

Campbell, Harry (author)

Kirin, Mirna (author)

Pehlic, Marina (author)

Faletra, Flavio (author)

Porteous, David (author)

Pistis, Giorgio (author)

Widén, Elisabeth (author)

Salomaa, Veikko (author)

Koskinen, Seppo (author)

Fischer, Krista (author)

Lehtimäki, Terho (author)

Heath, Andrew (author)

McCarthy, Mark I (author)

Rivadeneira, Fernando (author)

Montgomery, Grant W (author)

Tiemeier, Henning (author)

Hartikainen, Anna-Liisa (author)

Madden, Pamela A F (author)

d'Adamo, Pio (author)

Hastie, Nicholas D (author)

Gyllensten, Ulf (author): Uppsala universitet,Genomik,Science for Life Laboratory, SciLifeLab

Wright, Alan F (author)

van Duijn, Cornelia M (author)

Dunlop, Malcolm (author)

Rudan, Igor (author)

Gasparini, Paolo (author)

Pramstaller, Peter P (author)

Deary, Ian J (author)

Toniolo, Daniela (author)

Eriksson, Johan G (author)

Jula, Antti (author)

Raitakari, Olli T (author)

Metspalu, Andres (author)

Perola, Markus (author)

Järvelin, Marjo-Riitta (author)

Uitterlinden, André (author)

Visscher, Peter M (author)

Wilson, James F (author)

show less...

(creator_code:org_t)

2012-07-19
2012
English.
In: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 8:7, s. e1002655-

Related links:: https://uu.diva-port... (primary) (Raw object); show more...; https://journals.plo...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Stature is a classical and highly heritable complex trait, with 80%–90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive variants influencing human height; however, little attention has been given to the potential role of recessive genetic effects. Here, we investigated genome-wide recessive effects by an analysis of inbreeding depression on adult height in over 35,000 people from 21 different population samples. We found a highly significant inverse association between height and genome-wide homozygosity, equivalent to a height reduction of up to 3 cm in the offspring of first cousins compared with the offspring of unrelated individuals, an effect which remained after controlling for the effects of socio-economic status, an important confounder (χ2 = 83.89, df = 1; p = 5.2×10−20). There was, however, a high degree of heterogeneity among populations: whereas the direction of the effect was consistent across most population samples, the effect size differed significantly among populations. It is likely that this reflects true biological heterogeneity: whether or not an effect can be observed will depend on both the variance in homozygosity in the population and the chance inheritance of individual recessive genotypes. These results predict that multiple, rare, recessive variants influence human height. Although this exploratory work focuses on height alone, the methodology developed is generally applicable to heritable quantitative traits (QT), paving the way for an investigation into inbreeding effects, and therefore genetic architecture, on a range of QT of biomedical importance.

Find in a library

PLOS Genetics (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: McQuillan, Ruth; Eklund, Niina; Pirastu, Nicola; Kuningas, Maris; McEvoy, Brian P; Esko, Tõnu; show more...; Corre, Tanguy; Davies, Gail; Kaakinen, Marika; Lyytikäinen, Leo ...; Kristiansson, Ka ...; Havulinna, Aki S; Gögele, Martin; Vitart, Veroniqu ...; Tenesa, Albert; Aulchenko, Yurii; Hayward, Carolin ...; Johansson, Åsa; Boban, Mladen; Ulivi, Sheila; Robino, Antoniet ...; Boraska, Vesna; Igl, Wilmar; Wild, Sarah H; Zgaga, Lina; Amin, Najaf; Theodoratou, Evr ...; Polašek, Ozren; Girotto, Giorgia; Lopez, Lorna M; Sala, Cinzia; Lahti, Jari; Laatikainen, Tii ...; Prokopenko, Inga; Kals, Mart; Viikari, Jorma; Yang, Jian; Pouta, Anneli; Estrada, Karol; Hofman, Albert; Freimer, Nelson; Martin, Nicholas ...; Kähönen, Mika; Milani, Lili; Heliövaara, Mark ...; Vartiainen, Erkk ...; Räikkönen, Katri; Masciullo, Corra ...; Starr, John M; Hicks, Andrew A; Esposito, Laura; Kolčić, Ivana; Farrington, Susa ...; Oostra, Ben; Zemunik, Tatijan ...; Campbell, Harry; Kirin, Mirna; Pehlic, Marina; Faletra, Flavio; Porteous, David; Pistis, Giorgio; Widén, Elisabeth; Salomaa, Veikko; Koskinen, Seppo; Fischer, Krista; Lehtimäki, Terho; Heath, Andrew; McCarthy, Mark I; Rivadeneira, Fer ...; Montgomery, Gran ...; Tiemeier, Hennin ...; Hartikainen, Ann ...; Madden, Pamela A ...; d'Adamo, Pio; Hastie, Nicholas ...; Gyllensten, Ulf; Wright, Alan F; van Duijn, Corne ...; Dunlop, Malcolm; Rudan, Igor; Gasparini, Paolo; Pramstaller, Pet ...; Deary, Ian J; Toniolo, Daniela; Eriksson, Johan ...; Jula, Antti; Raitakari, Olli ...; Metspalu, Andres; Perola, Markus; Järvelin, Marjo- ...; Uitterlinden, An ...; Visscher, Peter ...; Wilson, James F; show less...

Articles in the publication: PLOS Genetics

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Evidence of Inbreeding Depression on Human Height

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub