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Sökning: WFRF:(Pelletier Luc)

  • Resultat 1-7 av 7
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1.
  • Tidskriftsartikel (refereegranskat)
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2.
  • Do Rego, Jean-Luc, et al. (författare)
  • Steroid biosynthesis within the frog brain : a model of neuroendocrine regulation
  • 2009
  • Ingår i: Annals of the New York Academy of Sciences. - 0077-8923 .- 1749-6632. ; 1163, s. 83-92
  • Tidskriftsartikel (refereegranskat)abstract
    • There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [(3)H]pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by gamma-aminobutyric acid (GABA), acting through GABA(A) receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropeptide (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.
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3.
  • Larochelle, Jean, et al. (författare)
  • Effect of nitisinone (NTBC) treatment on the clinical course of hepatorenal tyrosinemia in Québec.
  • 2012
  • Ingår i: Molecular genetics and metabolism. - 1096-7206. ; 107:1-2, s. 49-54
  • Tidskriftsartikel (refereegranskat)abstract
    • Hepatorenal tyrosinemia (HT1, fumarylacetoacetate hydrolase deficiency, MIM 276700) can cause severe hepatic, renal and peripheral nerve damage. In Québec, HT1 is frequent and neonatal HT1 screening is practiced. Nitisinone (NTBC, Orfadin ®) inhibits tyrosine degradation prior to the formation of toxic metabolites like succinylacetone and has been offered to HT1 patients in Québec since 1994.
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4.
  • Loisel, Julie, et al. (författare)
  • Insights and issues with estimating northern peatland carbon stocks and fluxes since the Last Glacial Maximum
  • 2017
  • Ingår i: Earth-Science Reviews. - 0012-8252 .- 1872-6828. ; 165, s. 59-80
  • Forskningsöversikt (refereegranskat)abstract
    • In this review paper, we identify and address key uncertainties related to four local and global controls of Holocene northern peatland carbon stocks and fluxes. First, we provide up-to-date estimates of the current northern peatland area (3.2 M km(2)) and propose a novel approach to reconstruct changes in the northern peatland area over time (Section 2). Second, we review the key methods and models that have been used to quantify total carbon stocks and methane emissions over time at the hemispheric scale, and offer new research directions to improve these calculations (Section 3). Our main proposed improvement relates to allocating different carbon stock and emission values for each of the two dominant vegetation assemblages (sedge and brown moss-dominated vs. Sphagnum-dominated peat). Third, we discuss and quantify the importance of basin heterogeneity in estimating peat volume at the local scale (Section 4.1). We also highlight the importance of age model selection when reconstructing carbon accumulation rates from a peat core (Section 4.2). Lastly, we introduce the role of biogeomorphological agents such as beaver activity in controlling carbon dynamics (Section 5.1) and review the newest research related to permafrost thaw (Section 5.2) and peat fire (Section 5.3) under climate change. Overall, this review summarizes new information from a broad range of peat-carbon studies, provides novel analysis of hemispheric-scale paleo datasets, and proposes new insights on how to translate peat-core data into carbon fluxes. It also identifies critical data gaps and research priorities, and many ways to consider and address them.
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5.
  • Louis, Véronique Leh, et al. (författare)
  • Pichia sorbitophila, an Interspecies Yeast Hybrid, Reveals Early Steps of Genome Resolution After Polyploidization
  • Ingår i: G3: Genes, Genomes, Genetics. - : Genetics Society of America. - 2160-1836. ; 2:2, s. 299-311
  • Tidskriftsartikel (refereegranskat)abstract
    • Polyploidization is an important process in the evolution of eukaryotic genomes, but ensuing molecular mechanisms remain to be clarified. Autopolyploidization or whole-genome duplication events frequently are resolved in resulting lineages by the loss of single genes from most duplicated pairs, causing transient gene dosage imbalance and accelerating speciation through meiotic infertility. Allopolyploidization or formation of interspecies hybrids raises the problem of genetic incompatibility (Bateson-Dobzhansky-Muller effect) andmay be resolved by the accumulation of mutational changes in resulting lineages. In this article, we show that an osmotolerant yeast species, Pichia sorbitophila, recently isolated in a concentrated sorbitol solution in industry, illustrates this last situation. Its genome is amosaic of homologous and homeologous chromosomes, or parts thereof, that corresponds to a recently formed hybrid in the process of evolution. The respective parental contributions to this genome were characterized using existing variations in GC content. The genomic changes that occurred during the short period since hybrid formation were identified (e.g., loss of heterozygosity, unilateral loss of rDNA, reciprocal exchange) and distinguished from those undergone by the two parental genomes after separation from their common ancestor (i.e., NUMT (NUclear sequences of MiTochondrial origin) insertions, gene acquisitions, gene location movements, reciprocal translocation). We found that the physiological characteristics of this new yeast species are determined by specific but unequal contributions of its two parents, one of which could be identified as very closely related to an extant Pichia farinosa strain.
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6.
  • Mills, James A, et al. (författare)
  • Archiving Primary Data: Solutions for Long-Term Studies.
  • 2015
  • Ingår i: Trends in Ecology & Evolution. - : Elsevier. - 1872-8383 .- 0169-5347. ; 30:10, s. 581-589
  • Tidskriftsartikel (refereegranskat)abstract
    • The recent trend for journals to require open access to primary data included in publications has been embraced by many biologists, but has caused apprehension amongst researchers engaged in long-term ecological and evolutionary studies. A worldwide survey of 73 principal investigators (Pls) with long-term studies revealed positive attitudes towards sharing data with the agreement or involvement of the PI, and 93% of PIs have historically shared data. Only 8% were in favor of uncontrolled, open access to primary data while 63% expressed serious concern. We present here their viewpoint on an issue that can have non-trivial scientific consequences. We discuss potential costs of public data archiving and provide possible solutions to meet the needs of journals and researchers.
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  • Resultat 1-7 av 7
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Pelletier, Luc (2)
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