SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Peng Tao) "

Sökning: WFRF:(Peng Tao)

  • Resultat 1-10 av 58
  • [1]23456Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Chang, Hong, et al. (författare)
  • Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.
  • 2017
  • Ingår i: Molecular neurobiology. - 1559-1182. ; 54:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide analysis (GWA) is an effective strategy to discover extreme effects surpassing genome-wide significant levels in studying complex disorders; however, when sample size is limited, the true effects may fail to achieve genome-wide significance. In such case, there may be authentic results among the pools of nominal candidates, and an alternative approach is to consider nominal candidates but are replicable across different samples. Here, we found that mRNA expression of the choline dehydrogenase gene (CHDH) was uniformly upregulated in the brains of bipolar disorder (BPD) patients compared with healthy controls across different studies. Follow-up genetic analyses of CHDH variants in multiple independent clinical datasets (including 11,564 cases and 17,686 controls) identified a risk SNP rs9836592 showing consistent associations with BPD (P meta = 5.72 × 10(-4)), and the risk allele indicated an increased CHDH expression in multiple neuronal tissues (lowest P = 6.70 × 10(-16)). These converging results may identify a nominal but true BPD susceptibility gene CHDH. Further exploratory analysis revealed suggestive associations of rs9836592 with childhood intelligence (P = 0.044) and educational attainment (P = 0.0039), a "proxy phenotype" of general cognitive abilities. Intriguingly, the CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous BPD genome-wide association studies (GWAS), but CHDH is lying outside of the core GWAS linkage disequilibrium (LD) region, and our studied SNP rs9836592 is ∼1.2 Mb 3' downstream of the previous GWAS loci (e.g., rs2251219) with no LD between them; thus, the association observed here is unlikely a reflection of previous GWAS signals. In summary, our results imply that CHDH may play a previously unknown role in the etiology of BPD and also highlight the informative value of integrating gene expression and genetic code in advancing our understanding of its biological basis.
  •  
2.
  • Peng, Jianhui, et al. (författare)
  • Achieving ultra-high electromagnetic wave absorption by anchoring Co0.33Ni0.33Mn0.33Fe2O4 nanoparticles on graphene sheets using microwave-assisted polyol method
  • 2018
  • Ingår i: Ceramics International. - ELSEVIER SCI LTD. - 0272-8842 .- 1873-3956. ; 44:17, s. 21015-21026
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The Co0.33Ni0.33Mn0.33Fe2O4/graphene nanocomposite for electromagnetic wave absorption was successfully synthesized from metal chlorides solutions and graphite powder by a simple and rapid microwave-assisted polyol method via anchoring the Co0.33Ni0.33Mn0.33Fe2O4 nanoparticles on the layered graphene sheets. The Fe3+, Co2+, Ni2+ and Mn2+ ions in the solutions were attracted by graphene oxide obtained from graphite and converted to the precursors Fe(OH)(3), Co(OH)(2), Ni(OH)(2), and Mn(OH)(2) under slightly alkaline conditions. After the transformations of the precursors to Co-Ni-Mn ferrites and conversion of graphene oxide to graphene under microwave irradiation at 170 degrees C in just 25 min, the Co0.33Ni0.33Mn0.33Fe2O4/graphene nanocomposite was prepared. The composition and structure of the nanocomposite were characterized by X-ray diffraction (XRD), inductive coupled plasma emission spectroscopy (ICP), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy (RS), transmission electron microscopy (TEM), etc. It was found that with the filling ratio of only 20 wt% and the thickness of 2.3 mm, the nanocomposite showed an ultra-wide effective absorption bandwidth (less than -10 dB) of 8.48 GHz (from 9.52 to 18.00 GHz) with the minimum reflection loss of - 24.29 dB. Compared to pure graphene sheets, Co0.33Ni0.33Mn0.33Fe2O4 nano particles and the counterparts reported in literature, the nanocomposite exhibited much better electromagnetic wave absorption, mainly attributed to strong wave attenuation, as a result of synergistic effects of dielectric loss, conductive loss and magnetic loss, and to good impedance matching. In view of its thin thickness, light weight and outstanding electromagnetic wave absorption property, the nanocomposite could be used as a very promising electromagnetic wave absorber.</p>
  •  
3.
  • Piao, S. L., et al. (författare)
  • The carbon budget of terrestrial ecosystems in East Asia over the last two decades
  • 2012
  • Ingår i: Biogeosciences. - Copernicus Publications. - 1726-4189. ; 9:9, s. 3571-3586
  • Tidskriftsartikel (refereegranskat)abstract
    • This REgional Carbon Cycle Assessment and Processes regional study provides a synthesis of the carbon balance of terrestrial ecosystems in East Asia, a region comprised of China, Japan, North and South Korea, and Mongolia. We estimate the current terrestrial carbon balance of East Asia and its driving mechanisms during 1990-2009 using three different approaches: inventories combined with satellite greenness measurements, terrestrial ecosystem carbon cycle models and atmospheric inversion models. The magnitudes of East Asia's terrestrial carbon sink from these three approaches are comparable: -0.293 +/- 0.033 PgC yr(-1) from inventory-remote sensing model-data fusion approach, -0.413 +/- 0.141 PgC yr(-1)(not considering biofuel emissions) or -0.224 +/- 0.141 PgC yr(-1) (considering biofuel emissions) for carbon cycle models, and -0.270 +/- 0.507 PgC yr(-1) for atmospheric inverse models. Here and in the following, the numbers behind +/- signs are standard deviations. The ensemble of ecosystem modeling based analyses further suggests that at the regional scale, climate change and rising atmospheric CO2 together resulted in a carbon sink of -0.289 +/- 0.135 PgC yr(-1), while land-use change and nitrogen deposition had a contribution of -0.013 +/- 0.029 PgC yr(-1) and -0.107 +/- 0.025 PgC yr(-1), respectively. Although the magnitude of climate change effects on the carbon balance varies among different models, all models agree that in response to climate change alone, southern China experienced an increase in carbon storage from 1990 to 2009, while northern East Asia including Mongolia and north China showed a decrease in carbon storage. Overall, our results suggest that about 13-27% of East Asia's CO2 emissions from fossil fuel burning have been offset by carbon accumulation in its terrestrial territory over the period from 1990 to 2009. The underlying mechanisms of carbon sink over East Asia still remain largely uncertain, given the diversity and intensity of land management processes, and the regional conjunction of many drivers such as nutrient deposition, climate, atmospheric pollution and CO2 changes, which cannot be considered as independent for their effects on carbon storage.
4.
  • Song, Guohe, et al. (författare)
  • TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway
  • 2016
  • Ingår i: Journal of Experimental & Clinical Cancer Research. - London, United Kingdom : BioMed Central. - 1756-9966 .- 1756-9966. ; 35:1
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>Background:</strong> Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study, we aim to investigate its biological function and clinical significance in human colon cancer.</p><p><strong>Methods:</strong> We analyzed the expression of TIMP1 in both public database (Oncomine and TCGA) and 94 cases of primary colon cancer and matched normal colon tissue specimens. The underlying mechanisms of altered TIMP1 expression on cell tumorigenesis, proliferation, and metastasis were explored in vitro and in vivo.</p><p><strong>Results:</strong> TIMP1 was overexpressed in colon tumorous tissues and lymph node metastasis specimens than in normal tissues. The aberrant expression of TIMP1 was significantly associated with the regional lymph node metastasis (p = 0.033), distant metastasis (p = 0.039), vascular invasion (p = 0.024) and the American Joint Committee on Cancer (AJCC) stage (p = 0.026). Cox proportional hazards model showed that TIMP1 was an independent prognostic indicator of disease-free survival (HR = 2.603, 95 % CI: 1.115-6.077, p = 0.027) and overall survival (HR = 2.907, 95 % CI: 1.254-6.737, p = 0.013) for patients with colon cancer. Consistent with this, our findings highlight that suppression of TIMP1 expression decreased proliferation, and metastasis but increased apoptosis by inducing TIMP1 specific regulated FAK-PI3K/AKT and MAPK pathway.</p><p><strong>Conclusion:</strong> TIMP1 might play an important role in promoting tumorigenesis and metastasis of human colon cancer and function as a potential prognostic indicator for colon cancer.</p>
  •  
5.
  • Tian, Yu-Peng, et al. (författare)
  • Investigations and facile synthesis of a series of novel multi-functional two-photon absorption materials
  • 2007
  • Ingår i: Journal of Materials Chemistry. - 0959-9428 .- 1364-5501. ; 17:34, s. 3646-3654
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Six centrosymmetric D-(pi-A)(3) structural triphenylamine derivatives that can be used as two- photon photopolymerization and optical data storage chromophores, tris[ 4-( 4- pyridylethenyl) phenyl] amine ( 1), tris[ 4-( 2- pyridylethenyl) phenyl] amine ( 2), tris( 4- cyanoethenylphenyl) amine ( 3), tris[ 4- butylacrylatephenyl] amine ( 4), tris[ 4- methylacrylatephenyl] amine ( 5) and tris[ 4- acrylicethenylphenyl] amine ( 6), have been successfully synthesized via a triple palladium-catalyzed Heck coupling reaction, and the novel chromophores were fully characterized by elemental analysis, IR, (1)H-NMR and ESIMS. The structure for 3 was determined by single crystal X-ray diffraction study. One- and two-photon absorption and fluorescence in various solvents were experimentally investigated. Two-photon initiated polymerization microfabrication and optical data recording experiments were carried out under 780 nm laser radiation, and the possible polymerization mechanism is discussed based on theoretical calculations. All the six chromophores have relatively large two-photon absorption crosssections, and exhibit optical memory and highly efficient two-photon initiated polymerization abilities.</p>
  •  
6.
  •  
7.
  • Bo, Tao, et al. (författare)
  • Hexagonal Ti2B2 monolayer : a promising anode material offering high rate capability for Li-ion and Na-ion batteries
  • 2018
  • Ingår i: Physical Chemistry, Chemical Physics - PCCP. - ROYAL SOC CHEMISTRY. - 1463-9076 .- 1463-9084. ; 20:34, s. 22168-22178
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Combining the first-principles density functional method and crystal structure prediction techniques, we report a series of hexagonal two-dimensional transition metal borides including Sc2B2, Ti2B2, V2B2, Cr2B2, Y2B2, Zr2B2, and Mo2B2. Their dynamic and thermal stabilities are testified by phonon and molecular dynamics simulations. We investigate the potential of the two-dimensional Ti2B2 monolayer as an anode material for Li-ion and Na-ion batteries. The Ti2B2 monolayer possesses high theoretical specific capacities of 456 and 342 mA h g(-1) for Li and Na, respectively. The very high Li/Na diffusivity with an ultralow energy barrier of 0.017/0.008 eV indicates an excellent charge-discharge capability. In addition, good electronic conductivity during the whole lithiation process is found by electronic structure calculations. The very small change in volume after the adsorption of one, two, and three layers of Li and Na ions indicates that the Ti2B2 monolayer is robust. These results highlight the suitability of Ti2B2 monolayer as well as the other two-dimensional transition metal borides as excellent anode materials for both Li-ion and Na-ion batteries.</p>
  •  
8.
  • Chadburn, Sarah E., et al. (författare)
  • Carbon stocks and fluxes in the high latitudes : using site-level data to evaluate Earth system models
  • 2017
  • Ingår i: Biogeosciences. - 1726-4170 .- 1726-4189. ; 14:22, s. 5143-5169
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>It is important that climate models can accurately simulate the terrestrial carbon cycle in the Arctic due to the large and potentially labile carbon stocks found in permafrost-affected environments, which can lead to a positive climate feedback, along with the possibility of future carbon sinks from northward expansion of vegetation under climate warming. Here we evaluate the simulation of tundra carbon stocks and fluxes in three land surface schemes that each form part of major Earth system models (JSBACH, Germany; JULES, UK; ORCHIDEE, France). We use a site-level approach in which comprehensive, high-frequency datasets allow us to disentangle the importance of different processes. The models have improved physical permafrost processes and there is a reasonable correspondence between the simulated and measured physical variables, including soil temperature, soil moisture and snow. We show that if the models simulate the correct leaf area index (LAI), the standard C3 photosynthesis schemes produce the correct order of magnitude of carbon fluxes. Therefore, simulating the correct LAI is one of the first priorities. LAI depends quite strongly on climatic variables alone, as we see by the fact that the dynamic vegetation model can simulate most of the differences in LAI between sites, based almost entirely on climate inputs. However, we also identify an influence from nutrient limitation as the LAI becomes too large at some of the more nutrient-limited sites. We conclude that including moss as well as vascular plants is of primary importance to the carbon budget, as moss contributes a large fraction to the seasonal CO2 flux in nutrient-limited conditions. Moss photosynthetic activity can be strongly influenced by the moisture content of moss, and the carbon uptake can be significantly different from vascular plants with a similar LAI. The soil carbon stocks depend strongly on the rate of input of carbon from the vegetation to the soil, and our analysis suggests that an improved simulation of photosynthesis would also lead to an improved simulation of soil carbon stocks. However, the stocks are also influenced by soil carbon burial (e.g. through cryoturbation) and the rate of heterotrophic respiration, which depends on the soil physical state. More detailed below-ground measurements are needed to fully evaluate biological and physical soil processes. Furthermore, even if these processes are well modelled, the soil carbon profiles cannot resemble peat layers as peat accumulation processes are not represented in the models. Thus, we identify three priority areas for model development: (1) dynamic vegetation including (a) climate and (b) nutrient limitation effects; (2) adding moss as a plant functional type; and an (3) improved vertical profile of soil carbon including peat processes.</p>
  •  
9.
  • Chadburn, Sarah E., et al. (författare)
  • Carbon stocks and fluxes in the high latitudes : Using site-level data to evaluate Earth system models
  • 2017
  • Ingår i: Biogeosciences. - Copernicus Publications. - 1726-4170. ; 14:22, s. 5143-5169
  • Tidskriftsartikel (refereegranskat)abstract
    • It is important that climate models can accurately simulate the terrestrial carbon cycle in the Arctic due to the large and potentially labile carbon stocks found in permafrost-affected environments, which can lead to a positive climate feedback, along with the possibility of future carbon sinks from northward expansion of vegetation under climate warming. Here we evaluate the simulation of tundra carbon stocks and fluxes in three land surface schemes that each form part of major Earth system models (JSBACH, Germany; JULES, UK; ORCHIDEE, France). We use a site-level approach in which comprehensive, high-frequency datasets allow us to disentangle the importance of different processes. The models have improved physical permafrost processes and there is a reasonable correspondence between the simulated and measured physical variables, including soil temperature, soil moisture and snow. We show that if the models simulate the correct leaf area index (LAI), the standard C3 photosynthesis schemes produce the correct order of magnitude of carbon fluxes. Therefore, simulating the correct LAI is one of the first priorities. LAI depends quite strongly on climatic variables alone, as we see by the fact that the dynamic vegetation model can simulate most of the differences in LAI between sites, based almost entirely on climate inputs. However, we also identify an influence from nutrient limitation as the LAI becomes too large at some of the more nutrient-limited sites. We conclude that including moss as well as vascular plants is of primary importance to the carbon budget, as moss contributes a large fraction to the seasonal CO2 flux in nutrient-limited conditions. Moss photosynthetic activity can be strongly influenced by the moisture content of moss, and the carbon uptake can be significantly different from vascular plants with a similar LAI. The soil carbon stocks depend strongly on the rate of input of carbon from the vegetation to the soil, and our analysis suggests that an improved simulation of photosynthesis would also lead to an improved simulation of soil carbon stocks. However, the stocks are also influenced by soil carbon burial (e.g. through cryoturbation) and the rate of heterotrophic respiration, which depends on the soil physical state. More detailed below-ground measurements are needed to fully evaluate biological and physical soil processes. Furthermore, even if these processes are well modelled, the soil carbon profiles cannot resemble peat layers as peat accumulation processes are not represented in the models. Thus, we identify three priority areas for model development: (1) dynamic vegetation including (a) climate and (b) nutrient limitation effects; (2) adding moss as a plant functional type; and an (3) improved vertical profile of soil carbon including peat processes.
10.
  • Chen, Lin, et al. (författare)
  • Seismically constrained thermo-rheological structure of the eastern Tibetan margin : Implication for lithospheric delamination
  • 2014
  • Ingår i: Tectonophysics. - Elsevier. - 0040-1951 .- 1879-3266. ; 627, s. 122-134
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The eastern Tibetan margin bordered by the Longmen Shan range exhibits significant lateral differences in the lithospheric structure and thermal state. To investigate the roles of these differences in mountain building, we construct a thermo-rheological model along a wide-angle seismic profile across the eastern Tibetan margin based on recent seismic and thermal observations. The thermal modeling is constrained by the surface heat flow data and crustal P wave velocity model. The construction of the theological envelopes is based on rock mechanics results, and involves two types of rheology: a weak case where the lower crust is felsic granulite and the lithospheric mantle is wet peridotite, and a strong case where the lower crust is mafic granulite and the lithospheric mantle is dry peridotite. The results demonstrate: (1) one high-temperature anomaly exists within the uppermost mantle beneath eastern Tibet, indicating that the crust in eastern Tibet is remarkably warmer than that in the Sichuan basin, and (2) the rheological strength of the lithospheric mantle beneath eastern Tibet is considerably weaker than that beneath the Sichuan basin. The rheological profiles are in accord with seismicity distribution. By combining these results with the observed crustal/lithospheric architecture, Pn velocity distribution and magmatism in the eastern Tibetan margin, we suggest that the delamination of a thickened lithospheric mantle root beneath eastern Tibet is responsible for the growth of the eastern Tibetan margin.</p>
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 58
  • [1]23456Nästa
Åtkomst
fritt online (11)
Typ av publikation
tidskriftsartikel (56)
konferensbidrag (2)
Typ av innehåll
refereegranskat (58)
övrigt vetenskapligt (1)
Författare/redaktör
Wang, Tao, (8)
Zhang, Peng (8)
Jiang, Tao, (6)
Han, Yuanyuan, (6)
Nikolajeff, Fredrik, (5)
Peng, Tao (5)
visa fler...
Ahlström, Anders, (4)
Peng, Shushi, (4)
Augustine, Robin, 19 ... (4)
Eriksson, Olle, 1960 ... (4)
Bo, Tao, (4)
Liu, Peng-Fei, (4)
Wang, Fangwei, (4)
Wang, Bao-Tian, (4)
Chen, Peng, (4)
Peng, Zhiwei, (4)
Engqvist, Håkan, (3)
Ciais, Philippe (3)
Zhou, Xin (3)
Engqvist, Håkan, 197 ... (3)
Stenmark, Pål, (3)
Berntsson, Ronnie P. ... (3)
Peng, Lisheng (3)
Dong, Min (3)
Qin, Wei (3)
Zhang, Tao, (3)
Liu, Sai Man (3)
Beard, Matthew (3)
Boone, Christopher (3)
Palan, Shilpa (3)
Krupp, Johannes (3)
Yu, Feifan, (3)
Zeng, Xianmin, (3)
Huang, Ketuan, (3)
Liao, Xiwen, (3)
Han, Chuangye, (3)
Wang, Xiangkun, (3)
Yu, Tingdong, (3)
Yang, Chengkun, (3)
Liu, Xiaoguang, (3)
Yu, Long, (3)
Zhu, Guangzhi, (3)
Su, Hao, (3)
Liu, Zhengqian, (3)
Liu, Zhengtao, (3)
Deng, Jianlong, (3)
Ye, Xinping, (3)
Tian, Yu-Peng, (3)
Rao, Mingjun, (3)
Zhang, Yuanbo, (3)
visa färre...
Lärosäte
Uppsala universitet (16)
Lunds universitet (12)
Kungliga Tekniska Högskolan (7)
Chalmers tekniska högskola (5)
Linköpings universitet (4)
Göteborgs universitet (3)
visa fler...
Umeå universitet (3)
Örebro universitet (3)
Karolinska Institutet (3)
Stockholms universitet (2)
Naturhistoriska riksmuseet (1)
visa färre...
Språk
Engelska (57)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (27)
Teknik (17)
Medicin och hälsovetenskap (11)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy