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Macrophage-associat...
Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
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- Barrenäs, Fredrik (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik,Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
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- Raehtz, Kevin (författare)
- Univ Pittsburgh, Dept Med, Div Infect Dis, Pittsburgh, PA USA;Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA USA
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- Xu, Cuiling (författare)
- Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA
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- Law, Lynn (författare)
- Univ Washington, Dept Immunol, Seattle, WA 98195 USA;Univ Washington, Ctr Innate Immun & Immune Dis, Seattle, WA 98195 USA
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- Green, Richard R. (författare)
- Univ Washington, Dept Immunol, Seattle, WA 98195 USA;Univ Washington, Ctr Innate Immun & Immune Dis, Seattle, WA 98195 USA
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- Silvestri, Guido (författare)
- Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA;Emory Univ, Yerkes Natl Primate Res Ctr, Div Microbiol & Immunol, Atlanta, GA 30322 USA
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- Bosinger, Steven E. (författare)
- Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA;Emory Univ, Yerkes Natl Primate Res Ctr, Div Microbiol & Immunol, Atlanta, GA 30322 USA
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- Nishida, Andrew (författare)
- Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
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- Li, Qingsheng (författare)
- Univ Nebraska, Sch Biol Sci, Nebraska Ctr Virol, Lincoln, NE USA
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- Lu, Wuxun (författare)
- Univ Nebraska, Sch Biol Sci, Nebraska Ctr Virol, Lincoln, NE USA
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- Zhang, Jianshui (författare)
- Univ Nebraska, Sch Biol Sci, Nebraska Ctr Virol, Lincoln, NE USA
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- Thomas, Matthew J. (författare)
- Univ Washington, Dept Immunol, Seattle, WA 98195 USA;Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA
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- Chang, Jean (författare)
- Univ Washington, Dept Immunol, Seattle, WA 98195 USA;Univ Washington, Ctr Innate Immun & Immune Dis, Seattle, WA 98195 USA
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- Smith, Elise (författare)
- Univ Washington, Dept Immunol, Seattle, WA 98195 USA;Univ Washington, Ctr Innate Immun & Immune Dis, Seattle, WA 98195 USA
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- Weiss, Jeffrey M. (författare)
- Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
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- Dawoud, Reem A. (författare)
- Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
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- Richter, George H. (författare)
- Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA
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- Trichel, Anita (författare)
- Univ Pittsburgh, Div Lab Anim Resources, Pittsburgh, PA USA
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- Ma, Dongzhu (författare)
- Univ Pittsburgh, Dept Orthoped Surg, Pittsburgh, PA USA
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- Peng, Xinxia (författare)
- North Carolina State Univ, Dept Mol Biomed Sci, Raleigh, NC 27695 USA
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- Komorowski, Jan (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik
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- Apetrei, Cristian (författare)
- Univ Pittsburgh, Dept Med, Div Infect Dis, Pittsburgh, PA USA;Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA USA
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- Pandrea, Ivona (författare)
- Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA USA;Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA
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- Gale, Michael, Jr. (författare)
- Univ Washington, Dept Immunol, Seattle, WA 98195 USA;Univ Washington, Ctr Innate Immun & Immune Dis, Seattle, WA 98195 USA;Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA
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(creator_code:org_t)
- 2019-11-08
- 2019
- Engelska.
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Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Natural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection. Here, we examined how this outcome is achieved by comparing a natural SIV host, African green monkey (AGM) to an AIDS susceptible species, rhesus macaque (RM). To asses gene expression profiles from acutely SIV infected AGMs and RMs, we developed a systems biology approach termed Conserved Gene Signature Analysis (CGSA), which compared RNA sequencing data from rectal AGM and RM tissues to various other species. We found that AGMs rapidly activate, and then maintain, evolutionarily conserved regenerative wound healing mechanisms in mucosal tissue. The wound healing protein fibronectin shows distinct tissue distribution and abundance kinetics in AGMs. Furthermore, AGM monocytes exhibit an embryonic development and repair/regeneration signature featuring TGF-beta and concomitant reduced expression of inflammatory genes compared to RMs. This regenerative wound healing process likely preserves mucosal integrity and prevents inflammatory insults that underlie immune exhaustion in RMs.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
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- Av författaren/redakt...
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Barrenäs, Fredri ...
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Raehtz, Kevin
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Xu, Cuiling
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Law, Lynn
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Green, Richard R ...
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Silvestri, Guido
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visa fler...
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Bosinger, Steven ...
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Nishida, Andrew
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Li, Qingsheng
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Lu, Wuxun
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Zhang, Jianshui
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Thomas, Matthew ...
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Chang, Jean
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Smith, Elise
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Weiss, Jeffrey M ...
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Dawoud, Reem A.
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Richter, George ...
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Trichel, Anita
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Ma, Dongzhu
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Peng, Xinxia
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Komorowski, Jan
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Apetrei, Cristia ...
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Pandrea, Ivona
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Gale, Michael, J ...
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