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Seasonal variation ...
Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue
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- Epstein, Mara M (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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- Andrén, Ove, 1963- (författare)
- Department of Urology, Örebro University Hospital, Örebro, Sweden
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- Kasperzyk, Julie L (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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- Shui, Irene M (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston MA, United States
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- Penney, Kathryn L (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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- Fall, Katja, 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Clinical Epidemiology and Biostatistics, Örebro University Hospital, Örebro, Sweden
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- Rider, Jennifer R (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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- Stampfer, Meir J (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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- Andersson, Swen-Olof, 1949- (författare)
- Department of Urology, Örebro University Hospital, Örebro, Sweden
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- Giovannucci, Edward (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Nutrition, Harvard School of Public Health, Boston MA, United States
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- Mucci, Lorelei A (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States; Centre for Public Health Services, University of Iceland, Reykjavik, Iceland
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(creator_code:org_t)
- 2012-06-19
- 2012
- Engelska.
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Ingår i: Cancer Causes and Control. - : Springer. - 0957-5243 .- 1573-7225. ; 23:8, s. 1359-1366
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE: Recent studies suggest variation in genes along the vitamin D pathway, as well as vitamin D receptor (VDR) protein levels, may be associated with prostate cancer. As serum vitamin D levels vary by season, we sought to determine whether the expression of genes on the vitamin D pathway, assessed in prostate tumor tissue, do the same.METHODS: Our study incorporates mRNA expression data from 362 men in the Swedish Watchful Waiting cohort, diagnosed between 1977 and 1999, and 106 men enrolled in the US Physicians' Health Study (PHS) diagnosed between 1983 and 2004. We also assayed for VDR protein expression among 832 men in the PHS and Health Professionals Follow-up Study cohorts. Season was characterized by date of initial tissue specimen collection categorically and by average monthly ultraviolet radiation levels. One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRα, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade. Variation was also examined separately among lethal and nonlethal cases.RESULTS: Tumor expression levels of the six genes did not vary significantly by season of tissue collection. No consistent patterns emerged from subgroup analyses by lethal versus nonlethal cases.CONCLUSIONS: Unlike circulating levels of 25(OH) vitamin D, expression levels of genes on the vitamin D pathway and VDR protein did not vary overall by season of tissue collection. Epidemiological analyses of vitamin D gene expression may not be biased by seasonality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Vitamin D; Vitamin D receptor; Prostate cancer; Gene expression; Seasonality; Biomarkers
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Epstein, Mara M
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Andrén, Ove, 196 ...
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Kasperzyk, Julie ...
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Shui, Irene M
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Penney, Kathryn ...
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Fall, Katja, 197 ...
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Rider, Jennifer ...
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Stampfer, Meir J
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Andersson, Swen- ...
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Giovannucci, Edw ...
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Mucci, Lorelei A
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Örebro universitet