| 1. |
- Gustavsson, Carl Gunnar, et al.
(författare)
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Blood viscosity in relation to blood haemoglobin concentration in healthy subjects and in patients with different cardiovascular diseases
- 1994
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Ingår i: Clinical Hemorheology. - New York, USA : Pergamon Press. - 0271-5198. ; 14:5, s. 677-683
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Blood viscosity was measured at different shear rates using a rotational viscometer, and the correlation between blood viscosity and blood haemoglobin concentration was studied. In 10 healthy controls correlation coefficients were: 0,966 at shear rate 40,0 s-1, 0,931 at 19,6 s-l, 0,817 at 2,3 s-1 and 0,816 at 0,8 s-l , p<0,01 to p < 0,001. The regression lines for these relationships were then applied to the patient groups to calculate what blood viscosity should be predicted solely from the individual haemoglobin concentration, "predicted blood viscosity". In 34 patients with cardiovascular diseases (20 patients with coronary artery disease (CAD), 8 patients with idiopathic dilated cardiomyopathy and 6 patients with primary pulmonary hypertension) the correlation between blood viscosity and haemoglobin concentration was less good, for the total patient material 0,748 to 0,613, p < 0,001 at all shear rates, and for the CAD patients 0,664 to 0,428, p < 0,05 at 3 out of 4 shear rates. Apparently the poorer correlation in the patients was due to a larger influence from factors unrelated to haemoglobin concentration/haematocrit, as the quotients between individually measured and predicted blood viscosity correlated with measured blood viscosity when the haematocrit factor had been eliminated by in vitro standardisation of sample haematocrits to 45%. Key words: Blood viscosity; Haemorheology; Haemoglobin concentration; Microcirculation.
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| 2. |
- Gustavsson, Carl Gunnar, et al.
(författare)
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Changed blood rheology in patients with idiopathic dilated cardiomyopathy
- 1994
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Ingår i: Angiology. - New York, USA : Westminster Publications, Inc.. - 0003-3197 .- 1940-1574. ; 45:2, s. 107-111
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Rheologic properties of blood were studied in 8 patients with dilated cardiomyopathy (DCM) and in 10 healthy subjects. Whole-blood viscosity was measured at four different shear rates, by means of a computer-controlled rotational viscometer. The patients had significantly higher blood viscosity at all shear rates, both at their natural hematocrits and after an in vitro adjustment of sample hematocrits to 45%. Erythrocyte filterability (5 μm pore size) was significantly lower, fibrinogen concentration significantly higher, and HDLcholesterol concentration significantly lower in the patient group. No significant differences were found regarding hematocrit, mean corpuscular volume, haemoglobin concentration, leukocyte count and filterability (8 μm pore size), plasma viscosity, and total cholesterol concentration. The measured hemorheologic abnormalities may contribute to the previously reported reduction of coronary blood flow reserve in DCM patients and to myocardial microcirculatory disturbances, which have been suggested as a cause for DCM.
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| 3. |
- Gustavsson, Carl G, et al.
(författare)
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Vein blood rheology alterations immediately after coronary angiography with iohexol, and one month later.
- 1996
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Ingår i: Clinical Hemorheology. - New York, USA : Pergamon Press. - 0271-5198. ; 16:6, s. 737-743
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Tidskriftsartikel (refereegranskat)abstract
- Abstract The effects of coronary angiography with iohexol upon vein blood rheology were studied before, immediately after and one month after angiography. Haematocrit decreased from 40.5 % to 39.0 % immediately after angiography (p < 0.01). When this was compensated for by in vitro standardisation of sample haematocrits to 45% there was a blood viscosity increase by 10.9 - 15.0 %, at the four studied shear rates 0.8 s-1, 2.3 s-1, 19.6 s-1, and 40.0 s-1 (p < 0.05 - p < 0.01). In unadjusted samples, i.e. at the patients natural haematocrits, there was only a slight and statistically non-significant blood viscosity increase. Plasma viscosity decreased immediately after angiography, and was even lower 1 month after angiography. The haematocrit reduction correlated significantly with the iohexol doses (correlation coefficient -0.852, p < 0.001), whereas no significant correlation was found between the contrast volumes and the alterations of blood and plasma viscosity. Except for plasma viscosity, there were no significant differences when the values before angiography and one month later were compared. Key words: Blood viscosity; Contrast media; Iohexol; Coronary angiography; Haematocrit; Haemorheology
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| 4. |
- Persson, Sylvi, et al.
(författare)
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Increased blood viscosity and decreased red cell filterability in patients with dilated cardiomyopathy
- 1991
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Ingår i: 7th European Conference on Clinical Haemorheology, Southampton, United Kingdom, July 16-19, 1991..
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Konferensbidrag (refereegranskat)abstract
- Abstract Rheological properties o f blood were studied in eight patients with dilated cardiomyopathy (DCM) and ten healthy controls . Whole blood viscosity was measured at 4 different shear rates, using a computer controlled rotational viscometer. Patients had significantly higher blood viscosity at all shear rates, both at the patients natural hematocrits and after in vitro adjustment of sample hematocrits to 45%. Erythrocyte filterability measured by St George's Filtrometer and expressed as red cell transit time (RCTT) were significantly lower in patients. Hematocrits were higher but not statistically significant. No differences were found regarding plasma viscosity, leucocyte count and leucocyte filterability. The blood rheology changes found in this study may contribute to myocardial perfusion disturbances, which have been suggested a s a cause for DCM. The coronary blood flow reserve is reduced in patients with DCM as well as in patients with angina pectoris, both with and without coronary artery stenosis (Syndrome X). In all three patients cathegories we have found increased blood viscosity but DCM differs by by normal plasma viscosity.
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| 5. |
- Persson, Sylvi, et al.
(författare)
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Studies on blood rheology in patients with primary pulmonary hypertension
- 1990
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Ingår i: 32nd Annual Meeting of the International College of Angiology, Toronto, Canada, June 24-29, 1990.
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Konferensbidrag (refereegranskat)abstract
- Abstract Background: Disturbances of blood rheology may create unfavorable changes of blood flow. The present study was performed to reveal possible hemorheologic abnormalities in primary pulmonary hypertension. Methods: Six patients with primary pulmonary hypertension (PPH) and 10 healthy controls of comparable age and smoking habits were studied. Blood viscosity was studied with a computer-controlled rotational viscometer, at natural hematocrit and at standardized hematocrit (45%). A capillary U-tube was used for plasma viscosity studies. Blood cell filterability was measured by theSt. George's Filtrometer (according to Dormandy et a1). Nucleopore filters of 5 (erythrocytes) and 8 (leukocytes) micrometers were used. Results: Whole blood viscosity in PPH patients was higher than in controls at four different shear rates (p<0.025-0.005). This was partly due to a higher concentration of red cells in the patients. After standardization to 45% however, the difference was still there at the highest shear rate used (40 s-1). It was also found that the passage time for erythrocytes through the filter was increased in the patient group, indicating decreased erythrocyte deformability. There were no significant differences between the groups in plasma viscosity, plasma fibrinogen, concentration of leukocytes, or leukocyte deformability. Conclusions: Patients with PPH show increased whole blood viscosity values. This is partly explained by an increased hematocrit. It is also found, however, that the deformability of erythrocytes in these patients is decreased. These changes may influence blood flow in an unfavorable way. Therapeutic measures against hemorheologic disturbances may be a possible complement to the commonly used vasodilatory treatment.
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| 6. |
- Persson, Sylvi Ulrika, et al.
(författare)
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Studies on blood rheology in patients with primary pulmonary hypertension
- 1991
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Ingår i: Angiology. - New York, USA : Westminster Publications, Inc.. - 0003-3197 .- 1940-1574. ; 42:10, s. 836-842
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Tidskriftsartikel (refereegranskat)abstract
- Abstract The rheologic properties of blood were studied in 6 patients with primary pulmonary hypertension (PPH) and compared with those of a control group of 10 healthy subjects. Blood viscosity was studied with a rotational viscometer and blood cell deformability with a filtrometer giving values for clogging particles (CP) and red cell transit time (RCTT). Blood viscosity at varying shear rates was found to be increased both at natural (p<0.025-0.005) and standardized hematocrit, 45% (p<0.05 at 40 s-1) in patients with PPH. Red cell deformability was reduced as indicated by a significant increase of RCTT (p<0.01). Increased values for hematocrit (p<0.001), hemoglobin concentration (p< 0.001), and erythrocyte count (p<0.005) were found and decreased values for mean corpuscular hemoglobin concentration (MCHC) (p< 0.025) and HDL cholesterol (p<0.005). Plasma viscosity, white cell deformability, white cell count, mean corpuscular volume (MCV), and plasma fibrinogen concentration did not significantly differ from the values found in the control group. It is concluded that patients with PPH have impaired blood rheology. The hemorheologic abnormalities in these patients may be of hemodynamic significance.
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| 7. |
- Högberg, Anders, 1968-, et al.
(författare)
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Small pieces of flint : Mesolithic contact patterns on the Småland highlands in south Sweden
- 2019
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Ingår i: Fornvännen. - Solna : Kungl. Vitterhets Historie och Antikvitets Akademien. - 0015-7813 .- 1404-9430. ; 114:4, s. 201-219
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Tidskriftsartikel (refereegranskat)abstract
- This text discusses a small assemblage of flint from an excavation of a Mesolithic site in the Småland highlands dated to c. 9.200 cal BP. Flint does not occur naturally in the area and the flint assemblage was brought to the site from the coast, about 45 kilometres to the west. The ambition of the study was to analyse a Mesolithic site with few and fragmented artefacts . By means of analyses of distribution patterns and detailed analyses of reduction processes and use-wear analysis it could be established that a variety of tasks had been performed at the site. The distribution of burnt flint together with there mains of a hut demonstrate that the site was spatially organized. Even though the number of flint pieces from the site is small, there are no indications that the find material is the result of short visits on the site. Instead, it is more likely a place that was used for stays of some duration. The use of non-local raw material indicates mobility and contact patterns that links present day west coast of Halland and south-east Scandinavia (Skåne and the Danish islands), with the Småland highland and the Markaryd area at the time of the settlement. The technological analys is indicates that stays in the inland lasted long enough to force the group to use and curate the flint tools in a careful way to make them last. But the visits were not so long that locally available raw materials, as for example quartz, had to be used. A general conclusion to be drawn from the result is that the number of lithic pieces in an assemblage, is not in proportion to the interpretative potential of a site.
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| 8. |
- Åvik Persson, Helene, et al.
(författare)
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Early and late signs that precede dying among older persons in nursing homes : the multidisciplinary team's perspective
- 2018
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Ingår i: BMC Geriatrics. - : BioMed Central. - 1471-2318. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- Background: Nursing home residents in Sweden are old, frail and usually have multiple morbidities which often make dying a prolonged suffering. It has been found that older persons at nursing homes receive far less palliative care than younger persons, partly because it is difficult to identify when the final stage of life begins. The identification may help the staff to enable the older person and their families to participate in planning the care in accordance with their own preferences and values. With this in mind the aim was to explore the experiences of early and late signs preceding dying in older persons in nursing homes from the multidisciplinary team's perspective. Methods: The focus group method was used to interview 20 health-care professionals on the basis of semi-structured questions. Four focus groups were conducted at four nursing homes in two counties in southern Sweden. The groups included different professionals such as assistant nurses, registered nurses, occupational therapists, physiotherapists, social workers and unit managers. The analysis was conducted according to the focus group method developed by Kruger and Casey. Results: The analysis revealed one major theme, from unawareness to obviousness, which illustrates that the participants experienced dying as a happening, not a process, and found it difficult to identify early signs. Even though it was a new way of thinking, several suggestions of early signs were presented. The main category "Going into a bubble" illustrates early signs, which meant that the older person showed signs of wanting to withdraw from the outside world. The main category "The body begins to shut down" illustrates late signs, which meant that the older person showed signs that indicate that the body starts to prepare for death. Conclusions: This study conveys new knowledge concerning the multidisciplinary team's collective experience of early and late signs that precede dying. This knowledge can increase the understanding of when a palliative care approach needs to be in place at nursing homes. The use of a palliative care approach in care planning requires consensus in the perception of the dying process of frail older persons.
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