| 1. |
- Gustafsson, Harald, et al.
(författare)
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Den dubbla blicken. En inledning
- 2007
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Ingår i: Den dubbla blicken. Historia i de nordiska samhällena. - 9789185767007 ; , s. 7-26
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Kesarimangalam, Sriram, 1983, et al.
(författare)
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Fluorescence Microscopy of Nanochannel-Confined DNA
- 2024
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Ingår i: Methods in Molecular Biology. - 1940-6029 .- 1064-3745. - 9781071633762 - 9781071633779 ; 2694, s. 175-202
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Stretching of DNA in nanoscale confinement allows for several important studies. The genetic contents of the DNA can be visualized on the single DNA molecule level, and the polymer physics of confined DNA and also DNA/protein and other DNA/DNA-binding molecule interactions can be explored. This chapter describes the basic steps to fabricate the nanostructures, perform the experiments, and analyze the data.
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| 3. |
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| 4. |
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| 5. |
- Persson, Fredrik, et al.
(författare)
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Fluorescence microscopy of nanochannel-confined DNA
- 2011
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Ingår i: Single Molecule Analysis : Methods and Protocols - Methods and Protocols. - Totowa, NJ : Humana Press. - 1064-3745. - 9781617792816 ; 783, s. 159-179
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Bokkapitel (refereegranskat)abstract
- Stretching of DNA in nanoscale confinement allows for direct visualization of the genetic contents of the DNA on the single DNA molecule level. DNA stretched in nanoscale confinement also allows for studies of DNA-protein interactions and DNA polymer physics in confined environments. This chapter describes the basic steps to fabricate the nanostructures, to perform the experiments, and to analyze the data.
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| 6. |
- Westerlund, Fredrik, 1978, et al.
(författare)
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Fluorescence microscopy of nanochannel-confined DNA
- 2018
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Ingår i: Methods in Molecular Biology. - New York, NY : Springer New York. - 1064-3745 .- 1940-6029. ; 1665, s. 173-198
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Bokkapitel (refereegranskat)abstract
- Stretching of DNA in nanoscale confinement allows for several important studies. The genetic contents of the DNA can be visualized on the single DNA molecule level and both the polymer physics of confined DNA and also DNA/protein and other DNA/DNA-binding molecule interactions can be explored. This chapter describes the basic steps to fabricate the nanostructures, perform the experiments and analyze the data.
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| 7. |
- Carlson, Julie, et al.
(författare)
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Salivary gland cancer: an update on present and emerging therapies
- 2013
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Ingår i: 2013 ASCO Educational Book. American Society of Clinical Oncology. ; , s. 257-63
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Bokkapitel (refereegranskat)abstract
- Malignant salivary gland tumors make up a small proportion of malignancies worldwide, yet vary widely in terms of histology, patterns of spread, and recurrence. A better understanding of this variability will guide appropriate treatment recommendations and lead to improved outcomes. Recent molecular genetic studies have uncovered a translocation-generated gene fusion network in salivary gland carcinomas that can be used for diagnosis, treatment decisions, and development of specific targeted therapies. The gene fusions encode novel fusion oncoproteins that function as transcriptional coactivators, tyrosine kinase receptors, and transcription factors involved in growth-factor signaling and cell-cycle regulation. While surgery currently is the primary therapy for operable tumors, radiation plays an important role in the postoperative setting, as well as in the definitive setting for inoperable lesions. An awareness of the risk factors for tumor recurrence and spread is important for both adjuvant therapy referrals and for radiation treatment planning purposes. Additionally, chemotherapy is being used increasingly in both the concurrent setting as a radiosensitizer, as well as in the palliative setting for metastatic tumors. Future trials investigating concurrent chemotherapy and radiation, as well as the use of targeted agents based on evolving molecular discoveries, will elucidate optimal personalized approaches for this challenging disease.
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| 8. |
- Feldmann, Andreas, 1981-, et al.
(författare)
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Utformning av produktionsnätverk - En empirisk studie
- 2007
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Ingår i: PLANs Forsknings- och tillämpningskonferens 2007: Kundfokuserade varor och tjänster. - Stockholm : PLAN - Logistikföreningen ;Jönköping :Tekniska högskolan, Högskolan i Jönköping. - 9789197644419 - 9197644412 ; , s. 67-82
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Henricsson, Fredrik, et al.
(författare)
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Polonium-210 in the bio-sphere : Bio-kinetics and biological effects
- 2012
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Ingår i: Radionuclides : Sources, Properties and Hazards - Sources, Properties and Hazards. - 9781619427488 ; , s. 33-60
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Bokkapitel (refereegranskat)abstract
- Polonium-210 is an alpha particle emitting radioactive element with a half-life of 138 days. It appears at the end of the decay-chain of Uranium-238 where the long lived Lead-210 (22.3 a) decays to Bismuth-210, and finally Polonium-210. 210Po is introduced into the biosphere through various routes of terrestrial and marine radioecological pathways. The level of 210Po activity in drinking water (5 Bq.kg-1) and in most common food items of terrestrial origin are usually low (0.04-0.1 Bq.kg-1 wet mass) and considered to be without concerns for human health. In some terrestrial food items such as reindeer and caribou, high 210Po levels (10 Bq.kg-1 wet mass) are due to their habit of grazing lichens (250 Bq.kg-1 dry weight). The food chain lichen-reindeer and man in arctic and sub-arctic regions is a unique pathway of 210Po to man. The enhancement of 210Po concentrations is also very pronounced in marine organisms feeding upon phytoplankton at the base of the food chain. Fish and seafood therefore have high activity concentrations of 210Po (2-15 Bq.kg-1). The daily dietary intakes of 210Po vary widely around the world with an estimated average median of about 160mBq.day-1. That corresponds to annual effective doses of about 70μSv.a-1 for 210Po. Populations mainly living on reindeer meat or marine food have a 5-10 fold higher annual effective doses. High activity concentrations (13 ± 3 Bq.kg-1) of Po-210 and Pb-210 are found in tobacco and its products. The annual effective radiation dose from 210Po for the whole body of a smoker who smokes 20 cigarettes per day has been estimated to 400μSv.a-1. The concentrations of 210Po in the air-ways and the lung tissues caused by smoking of tobacco contributes to a high radiation adsorbed dose to the respiratory epithelium, which contribute to the increased incidence of lung cancer observed among smokers, In December of 2006, former Russian intelligence operative Alexander Litvinenko died by what proved to be ingestion of polonium-210. This incident brought with it an increased interest of the bio-kinetics and radio-toxicity of 210Po. Alpha particles have a greater relative biological effectiveness (RBE) than gamma and X-rays considering cancer induction. But there are still no significant proofs in terms of increased risk in humans of in vivo bystander effects of 210Po alpha particle radiation. More work has to been done in studying RBE and the mechanism of the bystander effect and its relevance to cancer induction in man.
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