| 1. |
|
|
| 2. |
- Uvnäs-Moberg, Kerstin, et al.
(författare)
-
Physiological effects induced by stimulation of cutaneous sensory nerves, with a focus on oxytocin
- 2022
-
Ingår i: Current Opinion in Behavioral Sciences. - : Elsevier BV. - 2352-1546. ; 43, s. 159-166
-
Tidskriftsartikel (refereegranskat)abstract
- Gentle touch is mediated by CT afferents and is linked to the experience of pleasure by effects in the insular cortex. It is also associated with some antistress effects, lower levels of anxiety and pain reduction. A similar effect pattern is induced by oxytocin. In the present article, we describe the structure of the hypothalamic oxytocinergic system, in particular the pathways involved in reduction of anxiety, stress and pain. We detail how oxytocin exerts powerful anti-stress effects by antagonizing the release of and effects of corticotrophin releasing factor (CRF) and noradrenaline (NA), the main central regulators of the hypothalamo-pituitary-adrenal (HPA) axis and of the autonomic nervous system. It is suggested that CT fibers connect to the oxytocin system, and that oxytocin mediates the decrease of sympathetic nerve activity, increase of parasympathetic nerve activity as well as the reduction of pain and anxiety, induced by gentle touch. Thus, by reducing stress, repeated activation of CT afferents may be linked to better health.
|
|
| 3. |
- Vargas-Martinez, F., et al.
(författare)
-
Neuropeptides as neuroprotective agents: Oxytocin a forefront developmental player in the mammalian brain
- 2014
-
Ingår i: Progress in Neurobiology. - : Elsevier BV. - 0301-0082 .- 1873-5118. ; 123, s. 37-78
-
Forskningsöversikt (refereegranskat)abstract
- Oxytocin (OT) plays a major role in the establishment of social bonds. Social bonds are linked to the activation of cell signaling pathways that promote neurotrophic and synaptic maturation, plasticity and memory changes. Anti-social behavior is often associated with abnormalities of cell signaling pathways and/or defective function of brain neurotransmitters within behavioral CNS circuits due to unproper environmental and social factors, such as, diet, stress, chemical, air pollution, and noise, during gestational period or/and during early postnatal development. OT exerts an important regulatory functions in maternity and parental behaviors, lactation, attachment, bonding, trust, and sensorial functions such as: homeostatic cardiovascular control, satiety, touch, pain, analgesia and sexual behavior. Noteworthy, OT displays important neuroprotective properties against fetal programmed hypertension when administered during early postnatal life, added to its known anabolic properties shown in adult rats, e.g. body weight control, reduces blood pressure, and increases analgesia. This review focuses on the new evidences supporting OT's role as a major neuroprotective nonapeptide provided by its quality to reverse hypertension programmed in utero by undernutrition. (C) 2014 Elsevier Ltd. All rights reserved.
|
|
| 4. |
|
|
