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Inverse association...
Inverse association of leptin levels with renal cell carcinoma : results from a case-control study
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Spyridopoulos, Themistoklis N. (author)
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Petridou, Eleni Th. (author)
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Dessypris, Nick (author)
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Terzidis, Agapios (author)
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- Skalkidou, Alkistis (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa
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Deliveliotis, Charalambos (author)
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Chrousos, George P. (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Hormones (Athens, Greece). - 1109-3099. ; 8:1, s. 39-46
- Related links:
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http://www.hormones....
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https://urn.kb.se/re...
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Abstract
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- OBJECTIVE: Leptin is primarily produced in adipose tissue and appears to play a modulatory role between metabolism and immunity. Given that obesity, a state of chronic inflammation, is an established risk factor for Renal Cell Carcinoma (RCC), we investigated the association between plasma leptin levels and RCC risk. DESIGN: This case-control study included 70 patients with newly diagnosed, histologically confirmed RCC and 280 age-, gender- and district of residence-matched controls. Anthropometric data, socio-demographic variables, medical history, lifestyle habits and dietary data were derived from a personal interview. Serum leptin and adiponectin levels were determined using standard commercial kits. Adjusted odds ratios for RCC risk were derived through multiple logistic regression analyses. RESULTS: Leptin levels were inversely associated with RCC risk (OR: 0.53, CI: 0.28- 0.99, p = 0.05), even after controlling for potential confounding factors, such as Body Mass Index (BMI), recent weight change, history of diabetes mellitus and other obesity related hormones, notably adiponectin. CONCLUSIONS: The precise mechanism linking obesity with RCC remains unclear; however, the inverse association of leptin with RCC might be attributed, at least in part, to hormonal cross-talk with complex neuron-endocrine and immune circuits. These findings, if confirmed in prospective and interventional studies, might further elucidate the underlying mechanisms.
Keyword
- Adiponectin
- Immunity
- Inflammation
- Leptin
- Obesity
- Renal cell carcinoma
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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