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- Jung, Christian, et al.
(författare)
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A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention
- 2019
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Ingår i: Journal of critical care. - : W B SAUNDERS CO-ELSEVIER INC. - 0883-9441 .- 1557-8615. ; 52, s. 141-148
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to evaluate differences in outcome between patients admitted to intensive care unit (ICU) after elective versus acute surgery in a multinational cohort of very old patients (80 years; VIP). Predictors of mortality, with special emphasis on frailty, were assessed.Methods: In total, 5063 VIPs were induded in this analysis, 922 were admitted after elective surgery or intervention, 4141 acutely, with 402 after acute surgery. Differences were calculated using Mann-Whitney-U test and Wilcoxon test. Univariate and multivariable logistic regression were used to assess associations with mortality.Results: Compared patients admitted after acute surgery, patients admitted after elective surgery suffered less often from frailty as defined as CFS (28% vs 46%; p < 0.001), evidenced lower SOFA scores (4 +/- 5 vs 7 +/- 7; p < 0.001). Presence of frailty (CFS >4) was associated with significantly increased mortality both in elective surgery patients (7% vs 12%; p = 0.01), in acute surgery (7% vs 12%; p = 0.02).Conclusions: VIPs admitted to ICU after elective surgery evidenced favorable outcome over patients after acute surgery even after correction for relevant confounders. Frailty might be used to guide clinicians in risk stratification in both patients admitted after elective and acute surgery.
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- Balouet, J-C, et al.
(författare)
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Applied Dendroecology and Environmental Forensics. Characterizing and Age Dating Environmental Releases: : Fundamentals and Case Studies.
- 2007
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Ingår i: Environmental Forensics. - : Informa UK Limited. - 1527-5922 .- 1527-5930. ; 8:1-2, s. 1-17
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Tidskriftsartikel (refereegranskat)abstract
- Dendroecology, or the use of ring patterns to assess the age of trees and environmental factors controlling their growth, is a well-developed method in climatologic studies. This method holds great potential as a forensic tool for age dating, contamination assessment, and characterization of releases. Moreover, the method is independent of the physical presence of contamination at the time of sampling because it is focused on the effect rather than the cause. This review is one of the very few articles published to date exploring the forensic applicability of dendroecology. This article is organized in two parts: Part I describes the method principles and proposes a practical procedure for forensic applications; Part II exemplifies and validates the method through six case studies of successful forensic application (related to petroleum products and chlorinated solvent spills).
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- Carlan, C., et al.
(författare)
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Checkable Safety Cases : Enabling Automated Consistency Checks between Safety Work Products
- 2020
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Ingår i: Proceedings - 2020 IEEE 31st International Symposium on Software Reliability Engineering Workshops, ISSREW 2020. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728198705 ; , s. 295-302
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Konferensbidrag (refereegranskat)abstract
- In the automotive domain, the employment of agile development is currently hindered by the fact that the safety lifecycle, which implies the creation and maintenance of safety work products, is manually executed, being a complex and expensive process. Given a change in the system under consideration, ISO 26262 recommends that the impact of that change on the safety case of the system shall be assessed and that the safety case shall be correspondingly updated. To this end, in this paper, while assuming a model-based system and safety engineering context, we propose checkable safety case models, which are semantically rich safety case models integrated with system and safety engineering models (i.e., work products of a model-based safety lifecycle). The semantically rich specification and the model integration allow for automated consistency checks between the safety case and the system, specifically its engineering models. We exemplify our contributions via an in-vehicle driver assistance system for driving through intersections.
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