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Träfflista för sökning "WFRF:(Pfeiffer P.) ;pers:(Pfeiffer D.)"

Sökning: WFRF:(Pfeiffer P.) > Pfeiffer D.

  • Resultat 1-6 av 6
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1.
  • Pfeiffer, D., et al. (författare)
  • Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke
  • 2019
  • Ingår i: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 50:2, s. 298-304
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and Purpose-We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods-Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) and SiGN (Stroke Genetics Network)/ GISCOME (Genetics of Ischaemic Stroke Functional Outcome) networks. Genetic imbalance, defined as total number of protein-coding genes affected by copy number variations in an individual, was compared between patients with favorable (modified Rankin Scale score of 0-2) and unfavorable (modified Rankin Scale score of = 3) outcome after 3 months. Subgroup analyses were confined to patients with imbalance affecting ohnologs-a class of dose-sensitive genes, or to those with imbalance not affecting ohnologs. The association of imbalance with outcome was analyzed by logistic regression analysis, adjusted for age, sex, stroke subtype, stroke severity, and ancestry. Results-The study sample comprised 816 CADISP patients (age 44.2 +/- 10.3 years) and 2498 SiGN/GISCOME patients (age 67.7 +/- 14.2 years). Outcome was unfavorable in 122 CADISP and 889 SiGN/GISCOME patients. Multivariate logistic regression analysis revealed that increased genetic imbalance was associated with less favorable outcome in both samples (CADISP: P=0.0007; odds ratio=0.89; 95% CI, 0.82-0.95 and SiGN/GISCOME: P=0.0036; odds ratio=0.94; 95% CI, 0.91-0.98). The association was independent of age, sex, stroke severity on admission, stroke subtype, and ancestry. On subgroup analysis, imbalance affecting ohnologs was associated with outcome (CADISP: odds ratio=0.88; 95% CI, 0.80-0.95 and SiGN/GISCOME: odds ratio=0.93; 95% CI, 0.89-0.98) whereas imbalance without ohnologs lacked such an association. Conclusions-Increased genetic imbalance was associated with poorer functional outcome after IS in both study populations. Subgroup analysis revealed that this association was driven by presence of ohnologs in the respective copy number variations, suggesting a causal role of the deleterious effects of genetic imbalance.
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2.
  • Shergur J, Brown BA, Fedoseyev V, Koster U, Kratz KL, Sweryniak D, Walters WB, Wohr A, Fedorov D, Hannawald M, Hjorth-Jensen M, Mishin V, Pfeiffer B, Ressler JJ, Fynbo HOU, Hoff P, Mach H, Nilsson T, Wilhelmsen-Rolander K, Simon H, Bickley A and the ISOLD (författare)
  • Beta-Decay Studies of 135-137Sn using Selective Resonance Laser Ionization Techniques
  • 2002
  • Ingår i: Phys. Rev.. ; C65, s. 34313-
  • Tidskriftsartikel (refereegranskat)
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3.
  • Ball, A., et al. (författare)
  • Design, implementation and first measurements with the Medipix2-MXR detector at the Compact Muon Solenoid experiment
  • 2011
  • Ingår i: Journal of Instrumentation. - 1748-0221. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • The Medipix detector is the first device dedicated to measuring mixed-field radiation in the CMS (Compact Muon Solenoid) experiment cavern and able to distinguish between different particle types. Medipix2-MXR chips bump bonded to silicon sensors with various neutron conversion layers developed by the IEAP CTU in Prague were successfully installed for the 2008 LHC start-up in the CMS experimental and services caverns to measure the flux of various particle types, in particular neutrons. They have operated almost continuously during the 2010 run period, and the results shown here are from the proton run between the beginning of July and the end of October 2010. Clear signals are seen and different particle types have been observed during regular LHC luminosity running, and an agreement in the measured flux is found with the simulations. These initial results are promising, and indicate that these devices have the potential for further and future LHC and high energy physics applications as radiation monitoring devices for mixed field environments, including neutron flux monitoring. Further extensions are foreseen in the near future to increase the performance of the detector and its coverage for monitoring in CMS.
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4.
  • Pfeiffer, D., et al. (författare)
  • First measurements with new high-resolution gadolinium-GEM neutron detectors
  • 2016
  • Ingår i: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221 .- 1748-0221. ; 11
  • Tidskriftsartikel (refereegranskat)abstract
    • European Spallation Source instruments like the macromolecular diffractometer (NMX) require an excellent neutron detection efficiency, high-rate capabilities, time resolution, and an unprecedented spatial resolution in the order of a few hundred micrometers over a wide angular range of the incoming neutrons. For these instruments solid converters in combination with Micro Pattern Gaseous Detectors (MPGDs) are a promising option. A GEM detector with gadolinium converter was tested on a cold neutron beam at the IFE research reactor in Norway. The mu TPC analysis, proven to improve the spatial resolution in the case of B-10 converters, is extended to gadolinium based detectors. For the first time, a Gd-GEM was successfully operated to detect neutrons with a measured efficiency of 11.8% at a wavelength of 2 angstrom and a position resolution better than 250 mu m.
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5.
  • Sidiropoulou, O., et al. (författare)
  • Performance studies under high irradiation and ageing properties of resistive bulk Micromegas chambers at the new CERN Gamma Irradiation Facility
  • 2017
  • Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 845, s. 293-297
  • Tidskriftsartikel (refereegranskat)abstract
    • Resistive bulk Micromegas chambers, produced at CERN, have been installed at the new CERN Gamma Irradiation Facility (GIF++) in order to study the effects of ageing and to evaluate the detector behaviour under high irradiation. The chambers have an active area of 10×10cm2, strip pitch of 400μm and an amplification gap of 128μm. We present the detector performance as a function of the background rate of up to 20MHz/cm2.
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6.
  • Thuiner, P., et al. (författare)
  • Multi-GEM detectors in high particle fluxes
  • 2018
  • Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 174
  • Tidskriftsartikel (refereegranskat)abstract
    • Gaseous Electron Multipliers (GEM) are well known for stable operation at high particle fluxes. We present a study of the intrinsic limits of GEM detectors when exposed to veiy high particle fluxes of the order of MHz/mm2. We give an interpretation to the variations of the effective gain, which, as a function of the particle flux, first increases and then decreases. Wre also discuss the reduction of the ion back-flow with increasing flux. We present measurements and simulations of a triple GEM detector, describing its behaviour in terms of accumulation of positive ions that results in changes of the transfer fields and the amplification fields. The behaviour is expected to be common to all multi-stage amplification devices where the efficiency of transferring the electrons from one stage to the next one is not 100%.
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  • Resultat 1-6 av 6

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