| 1. |
- Aamodt, K., et al.
(författare)
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The ALICE experiment at the CERN LHC
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08002
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Forskningsöversikt (refereegranskat)abstract
- ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries, Its overall dimensions are 16 x 16 x 26 m(3) with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This paper describes in detail the detector components as installed for the first data taking in the summer of 2008.
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| 2. |
- Bruzzi, M, et al.
(författare)
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Radiation-hard semiconductor detectors for SuperLHC
- 2005
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 541:1-2, s. 189-201
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Tidskriftsartikel (refereegranskat)abstract
- An option of increasing the luminosity of the Large Hadron Collider (LHC) at CERN to 1035 cm-2 s-1 has been envisaged to extend the physics reach of the machine. An efficient tracking down to a few centimetres from the interaction point will be required to exploit the physics potential of the upgraded LHC. As a consequence, the semiconductor detectors close to the interaction region will receive severe doses of fast hadron irradiation and the inner tracker detectors will need to survive fast hadron fluences of up to above 1016cm-2. The CERN-RD50 project "Development of Radiation Hard Semiconductor Devices for Very High Luminosity Colliders" has been established in 2002 to explore detector materials and technologies that will allow to operate devices up to, or beyond, this limit. The strategies followed by RD50 to enhance the radiation tolerance include the development of new or defect engineered detector materials (SiC, GaN, Czochralski and epitaxial silicon, oxygen enriched Float Zone silicon), the improvement of present detector designs and the understanding of the microscopic defects causing the degradation of the irradiated detectors. The latest advancements within the RD50 collaboration on radiation hard semiconductor detectors will be reviewed and discussed in this work.
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| 3. |
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| 4. |
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| 5. |
- Piemonte, S., et al.
(författare)
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Serum sclerostin levels decline in post-menopausal women with osteoporosis following treatment with intermittent parathyroid hormone
- 2012
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Ingår i: Journal of Endocrinological Investigation. - : Springer. - 0391-4097 .- 1720-8386. ; 35:9, s. 866-868
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study was carried out in order to evaluate the effect of 18-month treatment with PTH (1-34) or PTH (1-84) on serum sclerostin levels in humans.Subjects and methods: We investigated 10 women with severe osteoporosis, previously treated with alendronate and 20 untreated osteoporotic women. Subjects with severe osteoporosis were randomly divided into 2 groups of 5 patients each; the first group was treated with 20 μg of PTH (1-34) and the second one with 100 μg of PTH (1-84) according to an open-label design. Fasting blood samples were collected at baseline and at 2, 4, and 24 h after hormone administration. The same protocol was followed at month 1, 6, 12, 18. Serum sclerostin levels were measured at each time point by a sandwich-type enzyme-linked immunosorbent assay.Results: Basal serum sclerostin levels were not significantly different between patients previously treated with alendronate and those never treated. No significant acute change of serum sclerostin levels was observed after PTH administration. Fitting a mixed effect regression model, we found a significant time effect (p=0.0012) using the sclerostin level as the response variable and the month of drug administration as a single covariate. Treatment with both PTH molecules induced a monthly mean reduction of sclerostin levels of 0.1956 pmol/l.Conclusions: Our results indicate that long-term therapy with PTH (1-34) or PTH (1-84) in women with osteoporosis previously treated with alendronate is associated with a reduction in circulating sclerostin levels. This is a putative mechanism through which PTH performs its anabolic action.
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| 6. |
- Swiderski, L., et al.
(författare)
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CsI:T1 Scintillation Pulse Shapes Measured with a SiPM Photodetector in a Liquid Nitrogen Cryostat
- 2016
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Ingår i: 2016 IEEE NUCLEAR SCIENCE SYMPOSIUM, MEDICAL IMAGING CONFERENCE AND ROOM-TEMPERATURE SEMICONDUCTOR DETECTOR WORKSHOP (NSS/MIC/RTSD). - : IEEE. - 9781509016426
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Konferensbidrag (refereegranskat)abstract
- A custom designed cryostat was constructed to measure the response of a CsI:T1 scintillator at temperatures close to the boiling point of liquid nitrogen (LN2). The scintillation light was collected by an HUV-HD SiPM from FBK with 6x6 mm(2) area and 25x25 mu m(2) cell pitch. The crystal size was 5x6x7 mm(3). All surfaces except the one facing the SiPM were covered with Teflon tape to enhance light collection by the photodetector. The performance of the experimental setup was verified at room temperature using analog electronics for signal processing. The crystal was mounted on a copper frame placed inside the LN2 cryostat. Since our goal was to measure the scintillation decay profiles, and the SiPM response at low temperatures becomes substantially slower than that observed at room temperature, the SiPM was mounted on a separate copper frame connected with the outer housing to keep it close to room temperature. The separation between the crystal surface and the SiPM was about 1.5 mm at room temperature, and it became smaller once the setup was cooled down to LN2 temperature, but even so the crystal and the photodetector were still separated. This approach allowed us to analyze scintillation pulse shapes of CsI:T1 at LN2 temperatures. An energy spectrum of 662 keV gamma-rays from a Cs-137 source was also recorded. The light yield of the CsI:T1 sample at LN2 temperature stands at about 6 % divided by 8 % of the value observed at room temperature.
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| 7. |
- Swiderski, L., et al.
(författare)
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CsLTl scintillation pulse shapes measured with a SiPM photodeteetor in a liquid nitrogen cryostat
- 2017
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Ingår i: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. - : Institute of Electrical and Electronics Engineers (IEEE).
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Konferensbidrag (refereegranskat)abstract
- A custom designed cryostat was constructed to measure the response of a CsI:Tl scintillator at temperatures close to the boiling point of liquid nitrogen (LN 2 ). The scintillation light was collected by an HUV-HD SiPM from FBK with 6×6 mm 2 area and 25×25 μm 2 cell pitch. The crystal size was 5×6×7 mm 3 . All surfaces except the one facing the SiPM were covered with Teflon tape to enhance light collection by the photodetector. The performance of the experimental setup was verified at room temperature using analog electronics for signal processing. The crystal was mounted on a copper frame placed inside the LN 2 cryostat. Since our goal was to measure the scintillation decay profiles, and the SiPM response at low temperatures becomes substantially slower than that observed at room temperature, the SiPM was mounted on a separate copper frame connected with the outer housing to keep it close to room temperature. The separation between the crystal surface and the SiPM was about 1.5 mm at room temperature, and it became smaller once the setup was cooled down to LN 2 temperature, but even so the crystal and the photodetector were still separated. This approach allowed us to analyze scintillation pulse shapes of CsI:Tl at LN 2 temperatures. An energy spectrum of 662 keV γ-rays from a 137 Cs source was also recorded. The light yield of the CsI:Tl sample at LN 2 temperature stands at about 6 % ÷ 8 % of the value observed at room temperature.
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| 8. |
- Swiderski, L., et al.
(författare)
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Scintillation response to gamma-rays measured at wide temperature range for Tl doped CsI with SiPM readout
- 2019
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : ELSEVIER SCIENCE BV. - 0168-9002 .- 1872-9576. ; 916, s. 32-36
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Tidskriftsartikel (refereegranskat)abstract
- A custom design cryostat was constructed to study the temperature dependence of relative light yield and non-proportionality trends of scintillators between -182 degrees C and +152 degrees C. CsI:Tl crystal response to gamma-rays and X-rays was investigated between 14 keV and 662 keV. Scintillation light was detected by a SiPM device, which was installed on a copper frame separated from the crystal and the cooling rod to enable operating the device at room temperature. The scintillation efficiency of CsI:Tl is peaked at about room temperature. The light yield of CsI:Tl at temperature close to liquid nitrogen boiling point is reduced by a factor of 15 in comparison to room temperature conditions. The non-proportionality of CsI:Tl scintillation response is high at low temperatures and is getting more proportional with increasing temperature.
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| 9. |
- Swiderski, L., et al.
(författare)
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Temperature Dependence of CsI:T1 Scintillation Pulse Shapes from-183 degrees C to+90 degrees C Measured with a SiPM Readout
- 2017
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Ingår i: 2017 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC). - : IEEE. - 9781538622827
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Konferensbidrag (refereegranskat)abstract
- A custom designed cryostat was constructed to measure the response of a CsI:T1 scintillator in temperature range from -183 degrees C up to +90 degrees C. The light readout was realized using a SiPM developed by FBK in near ultraviolet high density (NUV-HD) technology. The crystal and the SiPM were installed on separated copper frames. The crystal was cooled down by liquid nitrogen, while the SiPM was kept at temperature close to room temperature. A separation of 1 mm was kept between the crystal and the photodetector to ensure thermal isolation. The temperature of the crystal could be varied by heaters on the scintillator frame and was continuously monitored using a coil shaped resistance thermometer. The CsI:T1 scintillation decay profiles were recorded in the entire temperature range provided by the cryostat.
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| 10. |
- Swiderski, L., et al.
(författare)
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Temperature Dependence of CsI:Tl Scintillation Pulse Shapes from -183°C to +90°C Measured with a SiPM Readout
- 2018
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Ingår i: 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781538622827
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Konferensbidrag (refereegranskat)abstract
- A custom designed cryostat was constructed to measure the response of a CsI:Tl scintillator in temperature range from - 183 ^{circ}\mathrm {C} up to +90 ^{circ}\mathrm {C}. The light readout was realized using a SiPM developed by FBK in near ultraviolet high density (NUV-HD) technology. The crystal and the SiPM were installed on separated copper frames. The crystal was cooled down by liquid nitrogen, while the SiPM was kept at temperature close to room temperature. A separation of 1 mm was kept between the crystal and the photodetector to ensure thermal isolation. The temperature of the crystal could be varied by heaters on the scintillator frame and was continuously monitored using a coil shaped resistance thermometer. The CsI:Tl scintillation decay profiles were recorded in the entire temperature range provided by the cryostat.
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