| 1. |
- Björk, Ann-Kristin, et al.
(författare)
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Occupational allergic contact dermatitis to gloves, follow-up of investigated patients
- 2014
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 70:Suppl s1, s. 94-94
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: In the Department of Occupational and Environmental Dermatology there has been an increase in the inflow of patients, working as surgical nurses or surgeons. They have been referred due to presumed occupational contact dermatitis. Results from investigated patients have in part been presented previously, where the investigation has shownmultiple contact allergies caused by their occupational use of gloves. Allergens such as diphenylguanidine were found in the gloves and contact allergies to their rubber gloves were found. Many of the patients have been working for decades in their present occupation, but the hand dermatitis had often been present for less than a year. Objectives: To present a follow-up of patientswith hand dermatitis due to gloves. Methods: A follow-up of the patients and a structure for the investigation of the individual patient are given. Results: The cases will be presented with their contact allergies, howtheinvestigation isperformedandtheoutcomeof theprevention by avoiding gloves containing the allergens diagnosed in the individual patients. Conclusions: For health care personnel hand hygiene and the wearing of protective gloves are mandatory. Our findings indicate that the increased need to use rubber gloves and at the same time the exclusion of latex gloves give rise to new contact allergies which are clinically relevant. In the investigation, and the advice given to the patients, several factors have to be taken into consideration, including the fast change of glove material. The cases indicate the importance of close cooperation between chemists and dermatologists and the possibility to perform chemical analysis. Furthermore, and just as important for this patient group, is that with correct diagnosis and advice the contact dermatitis can actually heal completely and the patients continue in their work.
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| 2. |
- Li, Xuri, et al.
(författare)
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Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
- 2005
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Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 115:1, s. 118-127
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Tidskriftsartikel (refereegranskat)abstract
- The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
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| 3. |
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| 4. |
- Rosén, Gunnar, et al.
(författare)
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Samverkan : förutsättningar och möjligheter till stärkt arbetsmiljöarbete genom regional samverkan.
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rosén G, Hedlund A, Andersson I, Antonsson A, Bornberger-Dankvardt S, Klusell L, Pontén P. Samverkan. Förutsättningar och möjligheter till stärkt arbetsmiljöarbete genom regional eller lokal samverkan. Inom ramen för Tema SMARTA vid Arbetslivsinstitutet har ett delprojekt utgående från forskningsfrågan ”Hur bör en regional samverkan utformas för att stödja arbetsmiljöarbete i en region?” genomförts. Projektet har varit uppdelat i två etapper där den första delen givit förslag till en modell som beskriver hur en regional samverkan kring arbetsmiljöfrågor kan utvecklas från det att ett initiativ tas till avslut. Syftet med den andra etappen i projektet som redovisas i denna rapport har varit att ge stöd till aktörer, såväl drivande som medverkande, som avser att genom regional samverkan i projekt förbättra arbetsmiljö och arbetsmiljöarbete. Detta syfte nås genom att skapa underlag för utformning av stödmaterial. Den under första etappen beskrivna modellen för samverkan har använts som utgångspunkt för ett antal intervjuer av möjliga aktörer i en samverkan på en lokal nivå inom kommunen Borlänge och regionalt inom träbranschen i Bergslagen. Intervjuer har också gjorts på motsvarande sätt med centrala aktörer inom träbranschen och med personer som ingått i en referensgrupp. Förutom detta har också arbetsmöten genomförts tillsammans med centrala och regionala aktörer. Analysen av de samlade resultaten har genomförts i form av tre koncensusmöten där författarna deltagit. Den framtagna processmodellen ansågs av de intervjuade aktörerna ge en bra beskrivning av olika stadier i en samverkan. Intervjuerna av potentiella regionala och lokala aktörer visar på ett tydligt behov av och intresse för samverkan inom det aktuella området. Resultaten av dessa intervjuer tillsammans med övriga intervjuer och arbetsmöten visar vidare på vikten av att någon extern resurs kopplas in som drivande genom hela samverkan. De viktigaste förutsättningarna för en framgångsrik samverkan kan sammanfattas i åtta punkter: Förtroende och tillit; Gemensam värdegrund och tydliga mål; Egen nytta; Tydlighet; Interaktivitet; Tid; Resurser; Eldsjäl. Med utgångspunkt i resultaten bör ett fortsatt arbete inriktas mot att utveckla stödmaterial för intresserade aktörer samt att sprida kunskap genom kurser, seminarier etc.
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| 5. |
- Andersson, Ann-Catrin, et al.
(författare)
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Analysis of protein expression in cell microarrays : A tool for antibody-based proteomics
- 2006
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Ingår i: Journal of Histochemistry and Cytochemistry. - 0022-1554 .- 1551-5044. ; 54:12, s. 1413-1423
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Tidskriftsartikel (refereegranskat)abstract
- Tissue microarray (TMA) technology provides a possibility to explore protein expression patterns in a multitude of normal and disease tissues in a high-throughput setting. Although TMAs have been used for analysis of tissue samples, robust methods for studying in vitro cultured cell lines and cell aspirates in a TMA format have been lacking. We have adopted a technique to homogeneously distribute cells in an agarose gel matrix, creating an artificial tissue. This enables simultaneous profiling of protein expression in suspension- and adherent-grown cell samples assembled in a microarray. In addition, the present study provides an optimized strategy for the basic laboratory steps to efficiently produce TMAs. Presented modifications resulted in an improved quality of specimens and a higher section yield compared with standard TMA production protocols. Sections from the generated cell TMAs were tested for immunohistochemical staining properties using 20 well-characterized antibodies. Comparison of immunoreactivity in cultured dispersed cells and corresponding cells in tissue samples showed congruent results for all tested antibodies. We conclude that a modified TIVIA technique, including cell samples, provides a valuable tool for high-throughput analysis of protein expression, and that this technique can be used for global approaches to explore the human proteome.
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| 6. |
- Andersson, Ann-Catrin, et al.
(författare)
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Elevated levels of the human endogenous retrovirus ERV3 in human sebaceous glands
- 1996
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Ingår i: Journal of Investigative Dermatology. - : Elsevier BV. - 0022-202X .- 1523-1747. ; 106:1, s. 125-128
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Tidskriftsartikel (refereegranskat)abstract
- ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. Long terminal repeat-envelope (env) gene spliced mRNAs of 9 and 3.5 kb are widely expressed in human tissues and cells, but gag-pol mRNAs have not been found. Furthermore, the env gp70 gene contains an open reading frame throughout its length. The highest expression of ERV3 mRNA detected so far is in placenta and the lowest in choriocarcinoma cell lines. We have previously shown that the human monoblastic cell line U-937 and some normal and neoplastic tissues also express high levels of ERV3 env message by Northern blot analysis; however, this method does not distinguish between mRNA expression in different cell types in tissues. In this report, we have studied the ERV3 mRNA expression in specific cell types of human skin by in situ hybridization. We found high levels expression of ERV3 env mRNA in human sebaceous glands in normal skin and dermoid cysts of the ovary. In all glands, the expression is maximal in the periphery of the lobule and ceases towards the center in the region of characteristic holocrine secretion. Since it is known that the regulation of sebaceous glands is primarily via steroid hormones, particularly androgens, it is possible that expression of ERV3 is hormone dependent.
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| 7. |
- Andersson, Siv GE, et al.
(författare)
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The genome sequence of Rickettsia prowazekii and the origin of mitochondria
- 1998
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 396:6707, s. 133-140
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Tidskriftsartikel (refereegranskat)abstract
- We describe here the complete genome sequence (1,111,523 base pairs) of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus. This genome contains 834 protein-coding genes. The functional profiles of these genes show similarities to those of mitochondrial genes: no genes required for anaerobic glycolysis are found in either R. prowazekii or mitochondrial genomes, but a complete set of genes encoding components of the tricarboxylic acid cycle and the respiratory-chain complex is found in R. prowazekii. In effect, ATP production in Rickettsia is the same as that in mitochondria. Many genes involved in the biosynthesis and regulation of biosynthesis of amino acids and nucleosides in free-living bacteria are absent from R. prowazekii and mitochondria. Such genes seem to have been replaced by homologues in the nuclear (host) genome. The R. prowazekii genome contains the highest proportion of non-coding DNA (24%) detected so far in a microbial genome. Such non-coding sequences may be degraded remnants of 'neutralized' genes that await elimination from the genome. Phylogenetic analyses indicate that R. prowazekii is more closely related to mitochondria than is any other microbe studied so far.
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