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Sökning: WFRF:(Poor F)

  • Resultat 1-10 av 16
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1.
  • 2017
  • swepub:Mat__t
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  • Smolen, JS, et al. (författare)
  • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update
  • 2023
  • Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 82:1, s. 3-18
  • Tidskriftsartikel (refereegranskat)abstract
    • To provide an update of the EULAR rheumatoid arthritis (RA) management recommendations addressing the most recent developments in the field.MethodsAn international task force was formed and solicited three systematic literature research activities on safety and efficacy of disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs). The new evidence was discussed in light of the last update from 2019. A predefined voting process was applied to each overarching principle and recommendation. Levels of evidence and strengths of recommendation were assigned to and participants finally voted on the level of agreement with each item.ResultsThe task force agreed on 5 overarching principles and 11 recommendations concerning use of conventional synthetic (cs) DMARDs (methotrexate (MTX), leflunomide, sulfasalazine); GCs; biological (b) DMARDs (tumour necrosis factor inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab including biosimilars), abatacept, rituximab, tocilizumab, sarilumab and targeted synthetic (ts) DMARDs, namely the Janus kinase inhibitors tofacitinib, baricitinib, filgotinib, upadacitinib. Guidance on monotherapy, combination therapy, treatment strategies (treat-to-target) and tapering in sustained clinical remission is provided. Safety aspects, including risk of major cardiovascular events (MACEs) and malignancies, costs and sequencing of b/tsDMARDs were all considered. Initially, MTX plus GCs is recommended and on insufficient response to this therapy within 3–6 months, treatment should be based on stratification according to risk factors; With poor prognostic factors (presence of autoantibodies, high disease activity, early erosions or failure of two csDMARDs), any bDMARD should be added to the csDMARD; after careful consideration of risks of MACEs, malignancies and/or thromboembolic events tsDMARDs may also be considered in this phase. If the first bDMARD (or tsDMARD) fails, any other bDMARD (from another or the same class) or tsDMARD (considering risks) is recommended. With sustained remission, DMARDs may be tapered but should not be stopped. Levels of evidence and levels of agreement were high for most recommendations.ConclusionsThese updated EULAR recommendations provide consensus on RA management including safety, effectiveness and cost.
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  • Armbrecht, G., et al. (författare)
  • Vertebral Scheuermann's disease in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over
  • 2015
  • Ingår i: Osteoporosis International. - : Springer Science and Business Media LLC. - 1433-2965 .- 0937-941X. ; 26:10, s. 2509-2519
  • Tidskriftsartikel (refereegranskat)abstract
    • The Summary In 27 centres across Europe, the prevalence of deforming spinal Scheuermann's disease in age-stratified population-based samples of over 10,000 men and women aged 50+ averaged 8 % in each sex, but was highly variable between centres. Low DXA BMD was un-associated with Scheuermann's, helping the differential diagnosis from osteoporosis. Introduction This study aims to assess the prevalence of Scheuermann's disease of the spine across Europe in men and women over 50 years of age, to quantitate its association with bone mineral density (BMD) and to assess its role as a confounder for the radiographic diagnosis of osteoporotic fracture. Methods In 27 centres participating in the population-based European Vertebral Osteoporosis Study (EVOS), standardised lateral radiographs of the lumbar and of the thoracic spine from T4 to L4 were assessed in all those of adequate quality. The presence of Scheuermann's disease, a confounder for prevalent fracture in later life, was defined by the presence of at least one Schmorl's node or irregular endplate together with kyphosis (sagittal Cobb angle > 40A degrees between T4 and T12) or a wedged-shaped vertebral body. Alternatively, the (rare) Edgren-Vaino sign was taken as diagnostic. The 6-point-per-vertebral-body (13 vertebrae) method was used to assess osteoporotic vertebral shape and fracture caseness. DXA BMD of the L2-L4 and femoral neck regions was measured in subsets. We also assessed the presence of Scheuermann's by alternative published algorithms when these used the radiographic signs we assessed. Results Vertebral radiographic images from 4486 men and 5655 women passed all quality checks. Prevalence of Scheuermann's varied considerably between centres, and based on random effect modelling, the overall European prevalence using our method was 8 % with no significant difference between sexes. The highest prevalences were seen in Germany, Sweden, the UK and France and low prevalences were seen in Hungary, Poland and Slovakia. Centre-level prevalences in men and women were highly correlated. Scheuermann's was not associated with BMD of the spine or hip. Conclusions Since most of the variation in population impact of Scheuermann's was unaccounted for by the radiological and anthropometric data, the search for new genetic and environmental determinants of this disease is encouraged.
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  • Günlü, Onur, et al. (författare)
  • Information Theoretic Methods for Future Communication Systems
  • 2023
  • Ingår i: Entropy. - : MDPI. - 1099-4300. ; 25:3
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • It is anticipated that future communication systems will involve the use of new technologies, requiring high-speed computations using large amounts of data, in order to take advantage of data-driven methods for improving services and providing reliability and other benefits [...]
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  • Günlü, Onur, et al. (författare)
  • Private Key and Decoder Side Information for Secure and Private Source Coding
  • 2022
  • Ingår i: Entropy. - : MDPI. - 1099-4300. ; 24:12
  • Tidskriftsartikel (refereegranskat)abstract
    • We extend the problem of secure source coding by considering a remote source whose noisy measurements are correlated random variables used for secure source reconstruction. The main additions to the problem are as follows: (1) all terminals noncausally observe a noisy measurement of the remote source; (2) a private key is available to all legitimate terminals; (3) the public communication link between the encoder and decoder is rate-limited; and (4) the secrecy leakage to the eavesdropper is measured with respect to the encoder input, whereas the privacy leakage is measured with respect to the remote source. Exact rate regions are characterized for a lossy source coding problem with a private key, remote source, and decoder side information under security, privacy, communication, and distortion constraints. By replacing the distortion constraint with a reliability constraint, we obtain the exact rate region for the lossless case as well. Furthermore, the lossy rate region for scalar discrete-time Gaussian sources and measurement channels is established. An achievable lossy rate region that can be numerically computed is also provided for binary-input multiple additive discrete-time Gaussian noise measurement channels.
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  • Günlü, Onur, et al. (författare)
  • Quality of Security Guarantees for and with Physical Unclonable Functions and Biometric Secrecy Systems
  • 2023
  • Ingår i: Entropy. - : MDPI. - 1099-4300. ; 25:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Unique digital circuit outputs, considered as physical unclonable function (PUF) circuit outputs, can facilitate a secure and reliable secret key agreement. To tackle noise and high correlations between the PUF circuit outputs, transform coding methods combined with scalar quantizers are typically applied to extract the uncorrelated bit sequences reliably. In this paper, we create realistic models for these transformed outputs by fitting truncated distributions to them. We also show that the state-of-the-art models are inadequate to guarantee a target reliability level for all PUF outputs, which also means that secrecy cannot be guaranteed. Therefore, we introduce a quality of security parameter to control the percentage of the PUF circuit outputs for which a target security level can be guaranteed. By applying the finite-length information theory results to a public ring oscillator output dataset, we illustrate that security guarantees can be provided for each bit extracted from any PUF device by eliminating only a small subset of PUF circuit outputs. Furthermore, we conversely show that it is not possible to provide reliability or security guarantees without eliminating any PUF circuit output. Our holistic methods and analyses can be applied to any PUF type, as well as any biometric secrecy system, with continuous-valued outputs to extract secret keys with low hardware complexity.
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  • Günlü, Onur, et al. (författare)
  • Secure and Private Distributed Source Coding With Private Keys and Decoder Side Information
  • 2023
  • Ingår i: IEEE Transactions on Information Forensics and Security. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1556-6013 .- 1556-6021. ; 18, s. 3803-3816
  • Tidskriftsartikel (refereegranskat)abstract
    • The distributed source coding problem is extended by positing that noisy measurements of a remote source are the correlated random variables that should be reconstructed at another terminal. We consider a secure and private distributed lossy source coding problem with two encoders and one decoder such that (i) all terminals noncausally observe a noisy measurement of the remote source; (ii) a private key is available to each legitimate encoder and all private keys are available to the decoder; (iii) rate-limited noiseless communication links are available between each encoder and the decoder; (iv) the amount of information leakage to an eavesdropper about the correlated random variables is defined as (v) secrecy leakage, and privacy leakage is measured with respect to the remote source; and (vi) two passive attack scenarios are considered, where a strong eavesdropper can access both communication links and a weak eavesdropper can choose only one of the links to access. Inner and outer bounds on the rate regions defined under secrecy, privacy, communication, and distortion constraints are derived for both passive attack scenarios. When one or both sources should be reconstructed reliably, the rate region bounds are simplified.
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10.
  • Günlü, Onur, et al. (författare)
  • Secure and Private Source Coding with Private Key and Decoder Side Information
  • 2022
  • Ingår i: 2022 IEEE INFORMATION THEORY WORKSHOP (ITW). - : IEEE. - 9781665483414 - 9781665483421 ; , s. 226-231
  • Konferensbidrag (refereegranskat)abstract
    • The problem of secure source coding with multiple terminals is extended by considering a remote source whose noisy measurements are the correlated random variables used for secure source reconstruction. The main additions to the problem include 1) all terminals noncausally observe a noisy measurement of the remote source; 2) a private key is available to all legitimate terminals; 3) the public communication link between the encoder and decoder is rate-limited; and 4) the secrecy leakage to the eavesdropper is measured with respect to the encoder input, whereas the privacy leakage is measured with respect to the remote source. Exact rate regions are characterized for a lossy source coding problem with a private key, remote source, and decoder side information under security, privacy, communication, and distortion constraints. By replacing the distortion constraint with a reliability constraint, we obtain the exact rate region also for the lossless case. Furthermore, the lossy rate region for scalar discrete-time Gaussian sources and measurement channels is established.
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