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Search: WFRF:(Porcu E) > University of Gothenburg

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1.	Ahluwalia, T. S., et al. (author) Genome-wide association study of circulating interleukin 6 levels identifies novel loci 2021 In: Human molecular genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 30:5, s. 393-409 Journal article (peer-reviewed)abstract Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67428 (n(discovery)=52654 and n(replication)=14774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (P-combined=1.8x10(-11)), HLA-DRB1/DRB5 rs660895 on Chr6p21 (P-combined=1.5x10(-10)) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (P-combined=1.2x10(-122)). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
2.	Wood, AR, et al. (author) Defining the role of common variation in the genomic and biological architecture of adult human height 2014 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:11, s. 1173-1186 Journal article (peer-reviewed)
3.	Barban, N, et al. (author) Genome-wide analysis identifies 12 loci influencing human reproductive behavior 2016 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 48:12, s. 1462-1472 Journal article (peer-reviewed)
4.	Cleanthous, G., et al. (author) Regularity, continuity and approximation of isotropic Gaussian random fields on compact two-point homogeneous spaces 2020 In: Stochastic Processes and their Applications. - : Elsevier BV. - 0304-4149. ; 130:8, s. 4873-4891 Journal article (peer-reviewed)abstract Gaussian random fields defined over compact two-point homogeneous spaces are considered and Sobolev regularity and Hölder continuity are explored through spectral representations. It is shown how spectral properties of the covariance function associated to a given Gaussian random field are crucial to determine such regularities and geometric properties. Furthermore, fast approximations of random fields on compact two-point homogeneous spaces are derived by truncation of the series expansion, and a suitable bound for the error involved in such an approximation is provided. © 2020 Elsevier B.V.

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Porcu, E (4); Ohlsson, Claes, 1965 (3); Kanoni, S (3); Dedoussis, G. (3); Deloukas, P. (3); Kutalik, Z. (3); show more...; Lehtimaki, T. (3); Snieder, H. (3); Willemsen, G (2); Kaprio, J (2); Kivimaki, M (2); Tanaka, T. (2); Boomsma, DI (2); Amin, N (2); Magnusson, PKE (2); Albrecht, E (2); Trompet, S (2); Teumer, A (2); Gudnason, V (2); Hofman, A (2); Homuth, G (2); Montgomery, GW (2); Nalls, MA (2); Nauck, M (2); Uitterlinden, AG (2); Volzke, H (2); Martin, NG (2); van der Laan, SW (2); Froguel, P (2); Beekman, M (2); Nolte, IM (2); Lahti, J (2); Hamsten, A (2); Kumari, M (2); Boerwinkle, E (2); Eriksson, Joel (2); Kajantie, E. (2); McLachlan, S. (2); Deelen, J. (2); Grallert, H. (2); Mellstrom, D. (2); Muller-Nurasyid, M. (2); Raikkonen, K. (2); Scharnagl, H. (2); Van Heemst, D. (2); Vollenweider, P. (2); Waldenberger, M. (2); Marz, W. (2); Raitakari, O. (2); Campbell, H (2); show less...

University: University of Gothenburg (4)Undo refine; Uppsala University (3); Karolinska Institutet (3); Umeå University (1); Lund University (1); Stockholm School of Economics (1); show more...; Chalmers University of Technology (1); Högskolan Dalarna (1); show less...

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (3); Natural sciences (2)

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