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Identification of nine new susceptibility loci for endometrial cancer
-
- O'Mara, TA (author)
- QIMR Berghofer Medical Research Institute
- Glubb, DM (author)
- Amant, F (author)
- show more...
- Annibali, D (author)
- Ashton, K (author)
- Attia, J (author)
- Auer, PL (author)
- Beckmann, MW (author)
- Black, A (author)
- Bolla, MK (author)
- Brauch, H (author)
- Brenner, H (author)
- Brinton, L (author)
- Buchanan, DD (author)
- Burwinkel, B (author)
- Chang-Claude, J (author)
- Chanock, SJ (author)
- Chen, C (author)
- Chen, MM (author)
- Cheng, THT (author)
- Clarke, CL (author)
- Clendenning, M (author)
- Cook, LS (author)
- Couch, FJ (author)
- Cox, A (author)
- Crous-Bous, M (author)
- Day, F (author)
- Dennis, J (author)
- Depreeuw, J (author)
- Doherty, JA (author)
- Dork, T (author)
- Dowdy, SC (author)
- Durst, M (author)
- Ekici, AB (author)
- Fasching, PA (author)
- Fridley, BL (author)
- Friedenreich, CM (author)
- Fritschi, L (author)
- Fung, J (author)
- Garcia-Closas, M (author)
- Gaudet, MM (author)
- Giles, GG (author)
- Goode, EL (author)
- Gorman, M (author)
- Haiman, CA (author)
- Hankison, SE (author)
- Healey, CS (author)
- Hein, A (author)
- Hillemanns, P (author)
- Hodgson, S (author)
- Hoivik, EA (author)
- Holliday, EG (author)
- Hopper, JL (author)
- Hunter, DJ (author)
- Jones, A (author)
- Krakstad, C (author)
- Kristensen, VN (author)
- Lambrechts, D (author)
- Le Marchand, L (author)
- Liang, XL (author)
- Lissowska, J (author)
- Long, JR (author)
- Lu, LG (author)
- Magliocco, AM (author)
- Martin, L (author)
- McEvoy, M (author)
- Meindl, A (author)
- Michailidou, K (author)
- Milne, RL (author)
- Montgomery, GW (author)
- Nassir, R (author)
- Orlow, I (author)
- Otton, G (author)
- Palles, C (author)
- Perry, JRB (author)
- Peto, J (author)
- Pooler, L (author)
- Prescott, J (author)
- Proietto, T (author)
- Rebbeck, TR (author)
- Risch, HA (author)
- Rubner, M (author)
- Runnebaum, I (author)
- Sacerdote, C (author)
- Sarto, GE (author)
- Schumacher, F (author)
- Scott, RJ (author)
- Setiawan, VW (author)
- Shah, M (author)
- Sheng, X (author)
- Shu, XO (author)
- Southey, MC (author)
- Swerdlow, AJ (author)
- Trovik, J (author)
- Turman, C (author)
- Tyrer, JP (author)
- Vachon, C (author)
- Vanden Berg, D (author)
- Vanderstichele, A (author)
- Wang, ZM (author)
- Webb, PM (author)
- Wentzensen, N (author)
- Werner, HMJ (author)
- Winham, SJ (author)
- Xia, L (author)
- Xiang, YB (author)
- Yang, HP (author)
- Yu, H (author)
- Zheng, W (author)
- Pharoah, PDP (author)
- Dunning, AM (author)
- Kraft, P (author)
- De Vivo, I (author)
- Tomlinson, I (author)
- Easton, DF (author)
- Spurdle, AB (author)
- show less...
- (creator_code:org_t)
- 2018-08-09
- 2018
- English.
- In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 3166-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
- O'Mara, TA
- Glubb, DM
- Amant, F
- Annibali, D
- Ashton, K
- Attia, J
- show more...
- Auer, PL
- Beckmann, MW
- Black, A
- Bolla, MK
- Brauch, H
- Brenner, H
- Brinton, L
- Buchanan, DD
- Burwinkel, B
- Chang-Claude, J
- Chanock, SJ
- Chen, C
- Chen, MM
- Cheng, THT
- Clarke, CL
- Clendenning, M
- Cook, LS
- Couch, FJ
- Cox, A
- Crous-Bous, M
- Czene, K
- Day, F
- Dennis, J
- Depreeuw, J
- Doherty, JA
- Dork, T
- Dowdy, SC
- Durst, M
- Ekici, AB
- Fasching, PA
- Fridley, BL
- Friedenreich, CM
- Fritschi, L
- Fung, J
- Garcia-Closas, M
- Gaudet, MM
- Giles, GG
- Goode, EL
- Gorman, M
- Haiman, CA
- Hall, P
- Hankison, SE
- Healey, CS
- Hein, A
- Hillemanns, P
- Hodgson, S
- Hoivik, EA
- Holliday, EG
- Hopper, JL
- Hunter, DJ
- Jones, A
- Krakstad, C
- Kristensen, VN
- Lambrechts, D
- Le Marchand, L
- Liang, XL
- Lindblom, A
- Lissowska, J
- Long, JR
- Lu, LG
- Magliocco, AM
- Martin, L
- McEvoy, M
- Meindl, A
- Michailidou, K
- Milne, RL
- Mints, M
- Montgomery, GW
- Nassir, R
- Olsson, Håkan
- Orlow, I
- Otton, G
- Palles, C
- Perry, JRB
- Peto, J
- Pooler, L
- Prescott, J
- Proietto, T
- Rebbeck, TR
- Risch, HA
- Wolk, Alicja
- Rubner, M
- Runnebaum, I
- Sacerdote, C
- Sarto, GE
- Schumacher, F
- Scott, RJ
- Setiawan, VW
- Shah, M
- Sheng, X
- Shu, XO
- Southey, MC
- Swerdlow, AJ
- Tham, E
- Trovik, J
- Turman, C
- Tyrer, JP
- Vachon, C
- Vanden Berg, D
- Vanderstichele, ...
- Wang, ZM
- Webb, PM
- Wentzensen, N
- Werner, HMJ
- Winham, SJ
- Wolk, A
- Xia, L
- Xiang, YB
- Yang, HP
- Yu, H
- Zheng, W
- Pharoah, PDP
- Dunning, AM
- Kraft, P
- De Vivo, I
- Tomlinson, I
- Easton, DF
- Spurdle, AB
- Thompson, DJ
- show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Nature communica ...
- By the university
- Karolinska Institutet
- Uppsala University
- Lund University
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