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Sökning: WFRF:(Puhl M.)

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  • Schofield, James P. R., et al. (författare)
  • Stratification of asthma phenotypes by airway proteomic signatures
  • 2019
  • Ingår i: Journal of Allergy and Clinical Immunology. - Elsevier. - 0091-6749 .- 1097-6825. ; 144:1, s. 70-82
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Stratification by eosinophil and neutrophil counts increases our understanding of asthma and helps target therapy, but there is room for improvement in our accuracy in prediction of treatment responses and a need for better understanding of the underlying mechanisms. Objective: We sought to identify molecular subphenotypes of asthma defined by proteomic signatures for improved stratification. Methods: Unbiased label-free quantitative mass spectrometry and topological data analysis were used to analyze the proteomes of sputum supernatants from 246 participants (206 asthmatic patients) as a novel means of asthma stratification. Microarray analysis of sputum cells provided transcriptomics data additionally to inform on underlying mechanisms. Results: Analysis of the sputum proteome resulted in 10 clusters (ie, proteotypes) based on similarity in proteomic features, representing discrete molecular subphenotypes of asthma. Overlaying granulocyte counts onto the 10 clusters as metadata further defined 3 of these as highly eosinophilic, 3 as highly neutrophilic, and 2 as highly atopic with relatively low granulocytic inflammation. For each of these 3 phenotypes, logistic regression analysis identified candidate protein biomarkers, and matched transcriptomic data pointed to differentially activated underlying mechanisms. Conclusion: This study provides further stratification of asthma currently classified based on quantification of granulocytic inflammation and provided additional insight into their underlying mechanisms, which could become targets for novel therapies.
  • Engwall, Erik, et al. (författare)
  • Survey of cold ionospheric outflows in the magnetotail
  • 2009
  • Ingår i: Annales Geophysicae. - 0992-7689 .- 1432-0576. ; 27:8, s. 3185-3201
  • Tidskriftsartikel (refereegranskat)abstract
    • Low-energy ions escape from the ionosphere and constitute a large part of the magnetospheric content, especially in the geomagnetic tail lobes. However, they are normally invisible to spacecraft measurements, since the potential of a sunlit spacecraft in a tenuous plasma in many cases exceeds the energy-per-charge of the ions, and little is therefore known about their outflow properties far from the Earth. Here we present an extensive statistical study of cold ion outflows (0-60 eV) in the geomagnetic tail at geocentric distances from 5 to 19 R-E using the Cluster spacecraft during the period from 2001 to 2005. Our results were obtained by a new method, relying on the detection of a wake behind the spacecraft. We show that the cold ions dominate in both flux and density in large regions of the magnetosphere. Most of the cold ions are found to escape from the Earth, which improves previous estimates of the global outflow. The local outflow in the magnetotail corresponds to a global outflow of the order of 10(26) ions s(-1). The size of the outflow depends on different solar and magnetic activity levels.
  • Lindstrom, J., et al. (författare)
  • Take Action to Prevent Diabetes : The IMAGE Toolkit for the Prevention of Type 2 Diabetes in Europe
  • 2010
  • Ingår i: Hormone and Metabolic Research. - Wuppertal, Germany.. - 0018-5043. ; 42:Suppl 1, s. S37-S55
  • Tidskriftsartikel (refereegranskat)abstract
    • When we ask people what they value most, health is usually top of the list. While effective care is available for many chronic diseases, the fact remains that for the patient, the tax payer and the whole of society: Prevention is Better Than Cure. Diabetes and its complications are a serious threat to the survival and well-being of an increasing number of people. It is predicted that one in ten Europeans aged 20-79 will have developed diabetes by 2030. Once a disease of old age, diabetes is now common among adults of all ages and is beginning to affect adolescents and even children. Diabetes accounts for up to 18% of total healthcare expenditure in Europe. The Good News is That Diabetes is Preventable. Compelling evidence shows that the onset of diabetes can be prevented or delayed greatly in individuals at high risk (people with impaired glucose regulation). Clinical research has shown a reduction in risk of developing diabetes of over 50% following relatively modest changes in lifestyle that include adopting a healthy diet, increasing physical activity, and maintaining a healthy body weight. These results have since been reproduced in real-world prevention programmes. Even a delay of a few years in the progression to diabetes is expected to reduce diabetes-related complications, such as heart, kidney and eye disease and, consequently, to reduce the cost to society. A comprehensive approach to diabetes prevention should combine population based primary prevention with programmes targeted at those who are at high risk. This approach should take account of the local circumstances and diversity within modern society (e.g. social inequalities). The challenge goes beyond the healthcare system. We need to encourage collaboration across many different sectors: education providers, non-governmental organisations, the food industry, the media, urban planners and politicians all have a very important role to play.
  • Puhl-Quinn, P. A., et al. (författare)
  • Cluster and DMSP observations of SAID electric fields
  • 2007
  • Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 112:A5, s. A05219
  • Tidskriftsartikel (refereegranskat)abstract
    • [1] We report on magnetically conjugate Cluster and the Defense Meteorological Satellite Program (DMSP) satellite observations of subauroral ion drifts (SAID) during moderate geomagnetic activity levels on 8 April 2004. To our knowledge, the field-aligned separation of DMSP and Cluster (approximate to 28,000 km) is the largest separation ever analyzed with respect to the SAID phenomenon. Nonetheless, we show coherent, subauroral magnetosphere-ionosphere (MI) coupling along an entire field line in the post-dusk sector. The four Cluster satellites crossed SAID electric field channels with meridional magnitude E-M of 25 mV/m in situ and latitudinal extent Delta Lambda approximate to 0.5 degrees in the southern and northern hemispheres near 07:00 and 07:30 UT, respectively. Cluster was near perigee (R approximate to 4 R-E) and within 5 degrees (15 degrees) of the magnetic equator for the southern ( northern) crossing. The SAID were located near the plasmapause-within the ring current-plasmasphere overlap region. Downward field-aligned current signatures were observed across both SAID crossings. The most magnetically and temporally conjugate SAID field from DMSP F16A at 07:12 UT was practically identical in latitudinal size to that mapped from Cluster. Since the DMSP ion drift meter saturated at 3000 m/s (or similar to 114 mV/m) and the electrostatically mapped value for E-M from Cluster exceeded 300 mV/m, a magnitude comparison of E-M was not possible. Although the conjugate measurements show similar large-scale SAID features, the differences in substructure highlight the physical and chemical diversity of the conjugate regions.
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