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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Figlioli, G (author)
IFOM FIRC Inst Mol Oncol, Genome Diagnost Program, Milan, Italy,IFOM - The FIRC Institute of Molecular Oncology
Bogliolo, M (author)
Catucci, I (author)
show more...
Caleca, L (author)
Lasheras, SV (author)
Pujol, R (author)
Kiiski, JI (author)
Muranen, TA (author)
Barnes, DR (author)
Dennis, J (author)
Michailidou, K (author)
Bolla, MK (author)
Leslie, G (author)
Aalfs, CM (author)
Adank, MA (author)
Adlard, J (author)
Agata, S (author)
Cadoo, K (author)
Agnarsson, BA (author)
Ahearn, T (author)
Aittomaki, K (author)
Ambrosone, CB (author)
Andrews, L (author)
Anton-Culver, H (author)
Antonenkova, NN (author)
Arndt, V (author)
Arnold, N (author)
Aronson, KJ (author)
Arun, BK (author)
Asseryanis, E (author)
Auber, B (author)
Auvinen, P (author)
Azzollini, J (author)
Balmana, J (author)
Barkardottir, RB (author)
Barrowdale, D (author)
Barwell, J (author)
Freeman, LEB (author)
Beauparlant, CJ (author)
Beckmann, MW (author)
Behrens, S (author)
Benitez, J (author)
Berger, R (author)
Bermisheva, M (author)
Blanco, AM (author)
Blomqvist, C (author)
Bogdanova, NV (author)
Bojesen, A (author)
Bojesen, SE (author)
Bonanni, B (author)
Borg, A (author)
Brady, AF (author)
Brauch, H (author)
Brenner, Hermann (author)
German Cancer Research Centre
Bruning, T (author)
Burwinkel, B (author)
Buys, SS (author)
Caldes, T (author)
Caliebe, A (author)
Caligo, MA (author)
Campa, D (author)
Campbell, IG (author)
Canzian, F (author)
Castelao, JE (author)
Chang-Claude, J (author)
Chanock, SJ (author)
Claes, KBM (author)
Clarke, CL (author)
Collavoli, A (author)
Conner, TA (author)
Cox, DG (author)
Cybulski, C (author)
Czene, K (author)
Karolinska Institutet
Daly, MB (author)
de la Hoya, M (author)
Devilee, P (author)
Diez, O (author)
Ding, YC (author)
Dite, GS (author)
Ditsch, N (author)
Domchek, SM (author)
Dorfling, CM (author)
dos-Santos-Silva, I (author)
Durda, K (author)
Dwek, M (author)
Eccles, DM (author)
Ekici, AB (author)
Eliassen, AH (author)
Ellberg, Carolina (author)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Eriksson, M (author)
Karolinska Institutet
Evans, DG (author)
Fasching, PA (author)
IFOM - The FIRC Institute of Molecular Oncology
Figueroa, J (author)
Flyger, H (author)
Foulkes, WD (author)
Friebel, TM (author)
Friedman, E (author)
Gabrielson, M (author)
Karolinska Institutet
Gaddam, P (author)
Gago-Dominguez, M (author)
Gao, C (author)
Gapstur, SM (author)
Garber, J (author)
Garcia-Closas, M (author)
Garcia-Saenz, JA (author)
Gaudet, MM (author)
Gayther, SA (author)
Giles, GG (author)
Glendon, G (author)
Godwin, AK (author)
Goldberg, MS (author)
Goldgar, DE (author)
Guenel, P (author)
Gutierrez-Barrera, AM (author)
Haeberle, L (author)
Haiman, CA (author)
Hakansson, N (author)
Karolinska Institutet
Hall, Per (author)
Lund University,Lunds universitet,Karolinska Institutet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Hamann, U (author)
Harrington, PA (author)
Hein, A (author)
Heyworth, J (author)
Hillemanns, P (author)
Hollestelle, A (author)
Hopper, JL (author)
Hosgood, HD (author)
Howell, A (author)
Hu, CL (author)
Hulick, PJ (author)
Hunter, DJ (author)
Imyanitov, EN (author)
Isaacs, C (author)
Jakimovska, M (author)
Jakubowska, A (author)
James, P (author)
Janavicius, R (author)
Janni, W (author)
John, EM (author)
Jones, ME (author)
Jung, A (author)
Kaaks, R (author)
Karlan, BY (author)
Khusnutdinova, E (author)
Kitahara, CM (author)
Konstantopoulou, I (author)
Koutros, S (author)
Kraft, P (author)
Lambrechts, D (author)
Lazaro, C (author)
Le Marchand, L (author)
Lester, J (author)
Lesueur, F (author)
Lilyquist, J (author)
Loud, JT (author)
Lu, KRH (author)
Luben, RN (author)
Lubinski, J (author)
Mannermaa, A (author)
Manoochehri, M (author)
Manoukian, S (author)
Margolin, S (author)
Karolinska Institutet
Martens, JWM (author)
Maurer, T (author)
Mavroudis, D (author)
Mebirouk, N (author)
Meindl, A (author)
Menon, U (author)
Miller, A (author)
Montagna, M (author)
Nathanson, KL (author)
Neuhausen, SL (author)
Newman, WG (author)
Nguyen-Dumont, T (author)
Nielsen, FC (author)
Nielsen, S (author)
Nikitina-Zake, L (author)
Offit, K (author)
Olah, E (author)
Olopade, OI (author)
Olshan, AF (author)
Olson, JE (author)
Olsson, Håkan (author)
Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Osorio, A (author)
Ottini, L (author)
Peissel, B (author)
Peixoto, A (author)
Peto, J (author)
Plaseska-Karanfilska, D (author)
Pocza, T (author)
Presneau, N (author)
Pujana, MA (author)
Punie, K (author)
Rack, B (author)
Rantala, J (author)
Karolinska Institutet
Rashid, MU (author)
Rau-Murthy, R (author)
Rennert, G (author)
Lejbkowicz, F (author)
Rhenius, V (author)
Romero, A (author)
Rookus, MA (author)
Ross, EA (author)
Rossing, M (author)
Rudaitis, V (author)
Ruebner, M (author)
Saloustros, E (author)
Sanden, K (author)
Santamarina, M (author)
Scheuner, MT (author)
Schmutzler, RK (author)
Schneider, M (author)
Scott, C (author)
Senter, L (author)
Shah, M (author)
Sharma, P (author)
Shu, XO (author)
Simard, J (author)
Singer, CF (author)
Sohn, C (author)
Soucy, P (author)
Southey, MC (author)
Spinelli, JJ (author)
Steele, L (author)
Stoppa-Lyonnet, D (author)
Tapper, WJ (author)
Teixeira, MR (author)
Terry, MB (author)
Thomassen, M (author)
Thompson, J (author)
Thull, DL (author)
Tischkowitz, M (author)
Tollenaar, RAEM (author)
Torres, D (author)
Troester, MA (author)
Truong, T (author)
Tung, N (author)
Untch, M (author)
Vachon, CM (author)
van Rensburg, EJ (author)
van Veen, EM (author)
Vega, A (author)
Viel, A (author)
Wappenschmidt, B (author)
Weitzel, JN (author)
Wendt, C (author)
Wieme, G (author)
Wolk, Alicja (author)
Uppsala universitet,Karolinska Institutet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden
Yang, XHR (author)
Zheng, W (author)
Ziogas, A (author)
Zorn, KK (author)
Dunning, AM (author)
Lush, M (author)
Wang, Q (author)
McGuffog, L (author)
Parsons, MT (author)
Pharoah, PDP (author)
Fostira, F (author)
Toland, AE (author)
Andrulis, IL (author)
Ramus, SJ (author)
Swerdlow, AJ (author)
Greene, MH (author)
Chung, WK (author)
Milne, RL (author)
Chenevix-Trench, G (author)
Dork, T (author)
Schmidt, MK (author)
Easton, DF (author)
Radice, P (author)
Hahnen, E (author)
Antoniou, AC (author)
Couch, FJ (author)
Nevanlinna, H (author)
Surralles, J (author)
Peterlongo, P (author)
Balleine, R (author)
Baxter, R (author)
Braye, S (author)
Carpenter, J (author)
Dahlstrom, J (author)
Forbes, J (author)
Lee, CS (author)
Marsh, D (author)
Morey, A (author)
Pathmanathan, N (author)
Scott, R (author)
Simpson, P (author)
Spigelman, A (author)
Wilcken, N (author)
Yip, D (author)
Zeps, N (author)
Belotti, M (author)
Bertrand, O (author)
Birot, AM (author)
Buecher, B (author)
Caputo, S (author)
Dupre, A (author)
Fourme, E (author)
Gauthier-Villars, M (author)
Golmard, L (author)
Le Mentec, M (author)
Moncoutier, V (author)
de Pauw, A (author)
Saule, C (author)
Boutry-Kryza, N (author)
Calender, A (author)
Giraud, S (author)
Leone, M (author)
Bressac-de-Paillerets, B (author)
Caron, O (author)
Guillaud-Bataille, M (author)
Bignon, YJ (author)
Uhrhammer, N (author)
Bonadona, V (author)
Lasset, C (author)
Berthet, P (author)
Castera, L (author)
Vaur, D (author)
Bourdon, V (author)
Nogues, C (author)
Noguchi, T (author)
Popovici, C (author)
Remenieras, A (author)
Sobol, H (author)
Coupier, I (author)
Pujol, P (author)
Adenis, C (author)
Dumont, A (author)
Revillion, F (author)
Muller, D (author)
Barouk-Simonet, E (author)
Bonnet, F (author)
Bubien, V (author)
Longy, M (author)
Sevenet, N (author)
Gladieff, L (author)
Guimbaud, R (author)
Feillel, V (author)
Toulas, C (author)
Dreyfus, H (author)
Leroux, CD (author)
Peysselon, M (author)
Rebischung, C (author)
Legrand, C (author)
Baurand, A (author)
Bertolone, G (author)
Coron, F (author)
Faivre, L (author)
Jacquot, C (author)
Lizard, S (author)
Kientz, C (author)
Lebrun, M (author)
Prieur, F (author)
Fert-Ferrer, S (author)
Mari, V (author)
Venat-Bouvet, L (author)
Bezieau, S (author)
Delnatte, C (author)
Mortemousque, I (author)
Colas, C (author)
Coulet, F (author)
Soubrier, F (author)
Warcoin, M (author)
Bronner, M (author)
Sokolowska, J (author)
Collonge-Rame, MA (author)
Damette, A (author)
Gesta, P (author)
Lallaoui, H (author)
Chiesa, J (author)
Molina-Gomes, D (author)
Ingster, O (author)
Manouvrier-Hanu, S (author)
Lejeune, S (author)
Aghmesheh, M (author)
Greening, S (author)
Amor, D (author)
Gattas, M (author)
Botes, L (author)
Buckley, M (author)
Friedlander, M (author)
Koehler, J (author)
Meiser, B (author)
Saleh, M (author)
Salisbury, E (author)
Trainer, A (author)
Tucker, K (author)
Antill, Y (author)
Dobrovic, A (author)
Fellows, A (author)
Fox, S (author)
Harris, M (author)
Nightingale, S (author)
Phillips, K (author)
Sambrook, J (author)
Thorne, H (author)
Armitage, S (author)
Arnold, L (author)
Kefford, R (author)
Kirk, J (author)
Rickard, E (author)
Bastick, P (author)
Beesley, J (author)
Hayward, N (author)
Spurdle, A (author)
Walker, L (author)
Beilby, J (author)
Saunders, C (author)
Bennett, I (author)
Blackburn, A (author)
Bogwitz, M (author)
Gaff, C (author)
Lindeman, G (author)
Pachter, N (author)
Scott, C (author)
Sexton, A (author)
Visvader, J (author)
Taylor, J (author)
Winship, I (author)
Brennan, M (author)
Brown, M (author)
French, J (author)
Edwards, S (author)
Burgess, M (author)
Burke, J (author)
Patterson, B (author)
Butow, P (author)
Culling, B (author)
Caldon, L (author)
Callen, D (author)
Chauhan, D (author)
Eisenbruch, M (author)
Heiniger, L (author)
Chauhan, M (author)
Christian, A (author)
Dixon, J (author)
Kidd, A (author)
Cohen, P (author)
Colley, A (author)
Fenton, G (author)
Crook, A (author)
Dickson, R (author)
Field, M (author)
Cui, J (author)
Cummings, M (author)
Dawson, SJ (author)
DeFazio, A (author)
Delatycki, M (author)
Dudding, T (author)
Edkins, T (author)
Farshid, G (author)
Flanagan, J (author)
Fong, P (author)
Forrest, L (author)
Gallego-Ortega, D (author)
George, P (author)
Gill, G (author)
Kollias, J (author)
Haan, E (author)
Hart, S (author)
Jenkins, M (author)
Hunt, C (author)
Lakhani, S (author)
Lipton, L (author)
Lobb, L (author)
Mann, G (author)
McLachlan, SA (author)
O'Connell, S (author)
O'Sullivan, S (author)
Pieper, E (author)
Robinson, B (author)
Saunus, J (author)
Scott, E (author)
Shelling, A (author)
Williams, R (author)
Young, MA (author)
Genome One, Darlinghurst, NSW, Australia
show less...
 (creator_code:org_t)
2019-11-01
2019
English.
In: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 5, s. 38-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

arginine
arginine 658
ATM protein
BRCA1 protein
BRCA2 protein
butadiene diepoxide
checkpoint kinase 2
olaparib
partner and localizer of BRCA2
unclassified drug
Article
ATM protein gene
BRCA1 protein gene
BRCA2 protein gene
cell survival
checkpoint kinase 2 gene
chromosomal instability
chromosome fragility
controlled study
FANCM gene
female
gene
gene expression
gene mutation
genotype
human
informed consent
major clinical study
mRNA expression level
partner and localizer of BRCA2 gene
phenotype
priority journal
risk factor
sensitivity analysis
survival rate
triple negative breast cancer
Western blotting

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Figlioli, G
Bogliolo, M
Catucci, I
Caleca, L
Lasheras, SV
Pujol, R
show more...
Kiiski, JI
Muranen, TA
Barnes, DR
Dennis, J
Michailidou, K
Bolla, MK
Leslie, G
Aalfs, CM
Adank, MA
Adlard, J
Agata, S
Cadoo, K
Agnarsson, BA
Ahearn, T
Aittomaki, K
Ambrosone, CB
Andrews, L
Anton-Culver, H
Antonenkova, NN
Arndt, V
Arnold, N
Aronson, KJ
Arun, BK
Asseryanis, E
Auber, B
Auvinen, P
Azzollini, J
Balmana, J
Barkardottir, RB
Barrowdale, D
Barwell, J
Freeman, LEB
Beauparlant, CJ
Beckmann, MW
Behrens, S
Benitez, J
Berger, R
Bermisheva, M
Blanco, AM
Blomqvist, C
Bogdanova, NV
Bojesen, A
Bojesen, SE
Bonanni, B
Borg, A
Brady, AF
Brauch, H
Brenner, Hermann
Bruning, T
Burwinkel, B
Buys, SS
Caldes, T
Caliebe, A
Caligo, MA
Campa, D
Campbell, IG
Canzian, F
Castelao, JE
Chang-Claude, J
Chanock, SJ
Claes, KBM
Clarke, CL
Collavoli, A
Conner, TA
Cox, DG
Cybulski, C
Czene, K
Daly, MB
de la Hoya, M
Devilee, P
Diez, O
Ding, YC
Dite, GS
Ditsch, N
Domchek, SM
Dorfling, CM
dos-Santos-Silva ...
Durda, K
Dwek, M
Eccles, DM
Ekici, AB
Eliassen, AH
Ellberg, Carolin ...
Eriksson, M
Evans, DG
Fasching, PA
Figueroa, J
Flyger, H
Foulkes, WD
Friebel, TM
Friedman, E
Gabrielson, M
Gaddam, P
Gago-Dominguez, ...
Gao, C
Gapstur, SM
Garber, J
Garcia-Closas, M
Garcia-Saenz, JA
Gaudet, MM
Gayther, SA
Giles, GG
Glendon, G
Godwin, AK
Goldberg, MS
Goldgar, DE
Guenel, P
Gutierrez-Barrer ...
Haeberle, L
Haiman, CA
Hakansson, N
Hall, Per
Hamann, U
Harrington, PA
Hein, A
Heyworth, J
Hillemanns, P
Hollestelle, A
Hopper, JL
Hosgood, HD
Howell, A
Hu, CL
Hulick, PJ
Hunter, DJ
Imyanitov, EN
Isaacs, C
Jakimovska, M
Jakubowska, A
James, P
Janavicius, R
Janni, W
John, EM
Jones, ME
Jung, A
Kaaks, R
Karlan, BY
Khusnutdinova, E
Kitahara, CM
Konstantopoulou, ...
Koutros, S
Kraft, P
Lambrechts, D
Lazaro, C
Le Marchand, L
Lester, J
Lesueur, F
Lilyquist, J
Loud, JT
Lu, KRH
Luben, RN
Lubinski, J
Mannermaa, A
Manoochehri, M
Manoukian, S
Margolin, S
Martens, JWM
Maurer, T
Mavroudis, D
Mebirouk, N
Meindl, A
Menon, U
Miller, A
Montagna, M
Nathanson, KL
Neuhausen, SL
Newman, WG
Nguyen-Dumont, T
Nielsen, FC
Nielsen, S
Nikitina-Zake, L
Offit, K
Olah, E
Olopade, OI
Olshan, AF
Olson, JE
Olsson, Håkan
Osorio, A
Ottini, L
Peissel, B
Peixoto, A
Peto, J
Plaseska-Karanfi ...
Pocza, T
Presneau, N
Pujana, MA
Punie, K
Rack, B
Rantala, J
Rashid, MU
Rau-Murthy, R
Rennert, G
Lejbkowicz, F
Rhenius, V
Romero, A
Rookus, MA
Ross, EA
Rossing, M
Rudaitis, V
Ruebner, M
Saloustros, E
Sanden, K
Santamarina, M
Scheuner, MT
Schmutzler, RK
Schneider, M
Scott, C
Senter, L
Shah, M
Sharma, P
Shu, XO
Simard, J
Singer, CF
Sohn, C
Soucy, P
Southey, MC
Spinelli, JJ
Steele, L
Stoppa-Lyonnet, ...
Tapper, WJ
Teixeira, MR
Terry, MB
Thomassen, M
Thompson, J
Thull, DL
Tischkowitz, M
Tollenaar, RAEM
Torres, D
Troester, MA
Truong, T
Tung, N
Untch, M
Vachon, CM
van Rensburg, EJ
van Veen, EM
Vega, A
Viel, A
Wappenschmidt, B
Weitzel, JN
Wendt, C
Wieme, G
Wolk, Alicja
Yang, XHR
Zheng, W
Ziogas, A
Zorn, KK
Dunning, AM
Lush, M
Wang, Q
McGuffog, L
Parsons, MT
Pharoah, PDP
Fostira, F
Toland, AE
Andrulis, IL
Ramus, SJ
Swerdlow, AJ
Greene, MH
Chung, WK
Milne, RL
Chenevix-Trench, ...
Dork, T
Schmidt, MK
Easton, DF
Radice, P
Hahnen, E
Antoniou, AC
Couch, FJ
Nevanlinna, H
Surralles, J
Peterlongo, P
Balleine, R
Baxter, R
Braye, S
Carpenter, J
Dahlstrom, J
Forbes, J
Lee, CS
Marsh, D
Morey, A
Pathmanathan, N
Scott, R
Simpson, P
Spigelman, A
Wilcken, N
Yip, D
Zeps, N
Belotti, M
Bertrand, O
Birot, AM
Buecher, B
Caputo, S
Dupre, A
Fourme, E
Gauthier-Villars ...
Golmard, L
Le Mentec, M
Moncoutier, V
de Pauw, A
Saule, C
Boutry-Kryza, N
Calender, A
Giraud, S
Leone, M
Bressac-de-Paill ...
Caron, O
Guillaud-Bataill ...
Bignon, YJ
Uhrhammer, N
Bonadona, V
Lasset, C
Berthet, P
Castera, L
Vaur, D
Bourdon, V
Nogues, C
Noguchi, T
Popovici, C
Remenieras, A
Sobol, H
Coupier, I
Pujol, P
Adenis, C
Dumont, A
Revillion, F
Muller, D
Barouk-Simonet, ...
Bonnet, F
Bubien, V
Longy, M
Sevenet, N
Gladieff, L
Guimbaud, R
Feillel, V
Toulas, C
Dreyfus, H
Leroux, CD
Peysselon, M
Rebischung, C
Legrand, C
Baurand, A
Bertolone, G
Coron, F
Faivre, L
Jacquot, C
Lizard, S
Kientz, C
Lebrun, M
Prieur, F
Fert-Ferrer, S
Mari, V
Venat-Bouvet, L
Bezieau, S
Delnatte, C
Mortemousque, I
Colas, C
Coulet, F
Soubrier, F
Warcoin, M
Bronner, M
Sokolowska, J
Collonge-Rame, M ...
Damette, A
Gesta, P
Lallaoui, H
Chiesa, J
Molina-Gomes, D
Ingster, O
Manouvrier-Hanu, ...
Lejeune, S
Aghmesheh, M
Greening, S
Amor, D
Gattas, M
Botes, L
Buckley, M
Friedlander, M
Koehler, J
Meiser, B
Saleh, M
Salisbury, E
Trainer, A
Tucker, K
Antill, Y
Dobrovic, A
Fellows, A
Fox, S
Harris, M
Nightingale, S
Phillips, K
Sambrook, J
Thorne, H
Armitage, S
Arnold, L
Kefford, R
Kirk, J
Rickard, E
Bastick, P
Beesley, J
Hayward, N
Spurdle, A
Walker, L
Beilby, J
Saunders, C
Bennett, I
Blackburn, A
Bogwitz, M
Gaff, C
Lindeman, G
Pachter, N
Sexton, A
Visvader, J
Taylor, J
Winship, I
Brennan, M
Brown, M
French, J
Edwards, S
Burgess, M
Burke, J
Patterson, B
Butow, P
Culling, B
Caldon, L
Callen, D
Chauhan, D
Eisenbruch, M
Heiniger, L
Chauhan, M
Christian, A
Dixon, J
Kidd, A
Cohen, P
Colley, A
Fenton, G
Crook, A
Dickson, R
Field, M
Cui, J
Cummings, M
Dawson, SJ
DeFazio, A
Delatycki, M
Dudding, T
Edkins, T
Farshid, G
Flanagan, J
Fong, P
Forrest, L
Gallego-Ortega, ...
George, P
Gill, G
Kollias, J
Haan, E
Hart, S
Jenkins, M
Hunt, C
Lakhani, S
Lipton, L
Lobb, L
Mann, G
McLachlan, SA
O'Connell, S
O'Sullivan, S
Pieper, E
Robinson, B
Saunus, J
Scott, E
Shelling, A
Williams, R
Young, MA
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
NPJ breast cance ...
By the university
Karolinska Institutet
Uppsala University
Lund University

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