Sökning: WFRF:(Pye Stephen R.)
> (2018)
> Giwercman Aleksander >
Elevated luteinizin...
Elevated luteinizing hormone despite normal testosterone levels in older men-natural history, risk factors and clinical features
-
- Eendebak, Robert J.A.H. (författare)
- University of Manchester
-
- Ahern, Tomas (författare)
- University of Manchester
-
- Swiecicka, Agnieszka (författare)
- University of Manchester
-
visa fler...
-
- Pye, Stephen R. (författare)
- Christie NHS Foundation Trust
-
- O'Neill, Terence W. (författare)
- Christie NHS Foundation Trust
-
- Bartfai, Gyorgy (författare)
- University of Szeged
-
- Casanueva, Felipe F. (författare)
- Complejo Hospitalario Universitario de Santiago
-
- Maggi, Mario (författare)
- University of Florence
-
- Forti, Gianni (författare)
- University of Florence
-
- Giwercman, Aleksander (författare)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
-
- Han, Thang S. (författare)
- Royal Holloway University of London
-
- Słowikowska-Hilczer, Jolanta (författare)
- Medical University of Lodz
-
- Lean, Michael E.J. (författare)
- University of Glasgow
-
- Punab, Margus (författare)
- Tartu University Hospital
-
- Pendleton, Neil (författare)
- University of Manchester
-
- Keevil, Brian G. (författare)
- University Hospital of South Manchester NHS Foundation Trust
-
- Vanderschueren, Dirk (författare)
- Catholic University of Leuven
-
- Rutter, Martin K. (författare)
- Christie NHS Foundation Trust
-
- Tampubolon, Gindo (författare)
- University of Manchester
-
- Goodacre, Royston (författare)
- University of Manchester
-
- Huhtaniemi, Ilpo T. (författare)
- University of Turku
-
- Wu, Frederick C.W. (författare)
- University of Manchester
-
visa färre...
-
(creator_code:org_t)
- 2017-12-25
- 2018
- Engelska.
-
Ingår i: Clinical Endocrinology. - : Wiley. - 0300-0664. ; 88:3, s. 479-490
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://www.research...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Elevated luteinizing hormone (LH) with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the development of high LH (HLH, LH >9.4 U/L) in ageing men with normal T (T ≥ 10.5 nmol/L). Design, Patients and Measurements: We conducted a 4.3-year prospective observational study of 3369 community-dwelling European men aged 40-79 years. Participants were classified as follows: incident (i) HLH (n = 101, 5.2%); persistent (p) HLH (n = 128, 6.6%); reverted (r) HLH (n = 46, 2.4%); or persistent normal LH (pNLH, n = 1667, 85.8%). Potential predictors and changes in clinical features associated with iHLH and rHLH were analysed using regression models. Results: Age >70 years (OR = 4.12 [2.07-8.20]), diabetes (OR = 2.86 [1.42-5.77]), chronic pain (OR = 2.53 [1.34-4.77]), predegree education (OR = 1.79 [1.01-3.20]) and low physical activity (PASE ≤ 78, OR = 2.37 [1.24-4.50]) predicted development of HLH. Younger age (40-49 years, OR = 8.14 [1.35-49.13]) and nonsmoking (OR = 5.39 [1.48-19.65]) predicted recovery from HLH. Men with iHLH developed erectile dysfunction, poor health, cardiovascular disease (CVD) and cancer more frequently than pNLH men. In pHLH men, comorbidities, including CVD, developed more frequently, and cognitive and physical function deteriorated more, than in pNLH men. Men with HLH developed primary hypogonadism more frequently (OR = 15.97 [5.85-43.60]) than NLH men. Men with rHLH experienced a small rise in BMI. Conclusions: Elevation of LH with normal T is predicted by multiple factors, reverts frequently and is not associated with unequivocal evidence of androgen deficiency. High LH is a biomarker for deteriorating health in aged men who tend to develop primary hypogonadism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Ageing
- Hypogonadism
- Luteinizing hormone
- Physical function
- Testosterone
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Eendebak, Robert ...
-
Ahern, Tomas
-
Swiecicka, Agnie ...
-
Pye, Stephen R.
-
O'Neill, Terence ...
-
Bartfai, Gyorgy
-
visa fler...
-
Casanueva, Felip ...
-
Maggi, Mario
-
Forti, Gianni
-
Giwercman, Aleks ...
-
Han, Thang S.
-
Słowikowska-Hilc ...
-
Lean, Michael E. ...
-
Punab, Margus
-
Pendleton, Neil
-
Keevil, Brian G.
-
Vanderschueren, ...
-
Rutter, Martin K ...
-
Tampubolon, Gind ...
-
Goodacre, Roysto ...
-
Huhtaniemi, Ilpo ...
-
Wu, Frederick C. ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Annan medicin oc ...
-
och Gerontologi medi ...
- Artiklar i publikationen
-
Clinical Endocri ...
- Av lärosätet
-
Lunds universitet