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  • Wain, Louise V., et al. (författare)
  • Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
  • 2017
  • Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 70:3, s. E4-e19
  • Tidskriftsartikel (refereegranskat)abstract
    • Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
  • Evangelou, Evangelos, et al. (författare)
  • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
  • 2018
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
  • Tidskriftsartikel (refereegranskat)abstract
    • High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
  • Vu Trong, Thu, 1982-, et al. (författare)
  • Constellation of small quick-launch and self-deorbiting nano-satellites with AIS receivers for global ship traffic monitoring
  • 2011
  • Ingår i: 2nd Nano-Satellite Symposium, Tokyo, Japan, Mars 2011.
  • Konferensbidrag (refereegranskat)abstract
    • Since December 2004 the International Maritime Organization's International Convention for the Safety of Life at Sea requires that Automatic Identification System (AIS) has to be implemented on all international voyaging ships with gross tonnage of 300 or more tons, and on all passenger ships regardless of size. This stems from the need of collision avoidance, search-and-rescue operations and other maritime purposes. Ground-based AIS receiving station usually cannot cover ships over the horizon, but with space-based AIS signal receivers, the global ship monitoring became possible, providing data service for maritime administrations, cargo liners, and even navies. Since 2007, a number micro-satellites and nano-satellites have been launched for technical demonstration in this respect. However, at present the space-based global AIS data service is not fully operational and international cooperation is limited. In this paper, a constellation of 3 self-deorbiting nano-satellites, with a mass equivalent to 3U cubesats, carrying AIS receivers is proposed to complement the existing systems. The feasible study presented here showed that this mission can be realized at very low cost, and quick-launched. Three other important features of the mission are: international cooperation, making a practical use of smaller nano-satellites and taking the responsibility for deorbiting the satellites at the end of mission. It is also the hope that this mission will become a milestone that marks the maturity of smaller nanosats, and give the "student satellite" projects around the world a new dimension for real application and sustainable business application.
  • Warren, Helen R., et al. (författare)
  • Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
  • 2017
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 49:3, s. 403-415
  • Tidskriftsartikel (refereegranskat)abstract
    • Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
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