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The 12p13.33/RAD52 ...
The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
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Delahaye-Sourdeix, Manon (author)
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Oliver, Javier (author)
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Timofeeva, Maria N (author)
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Gaborieau, Valérie (author)
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- Johansson, Mattias (author)
- Genetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France
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Chabrier, Amélie (author)
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Wozniak, Magdalena B (author)
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Brenner, Darren R (author)
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Vallée, Maxime P (author)
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Anantharaman, Devasena (author)
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Lagiou, Pagona (author)
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Holcátová, Ivana (author)
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Richiardi, Lorenzo (author)
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Kjaerheim, Kristina (author)
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Agudo, Antonio (author)
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Castellsagué, Xavier (author)
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Macfarlane, Tatiana V (author)
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Barzan, Luigi (author)
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Canova, Cristina (author)
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Thakker, Nalin S (author)
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Conway, David I (author)
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Znaor, Ariana (author)
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Healy, Claire M (author)
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Ahrens, Wolfgang (author)
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Zaridze, David (author)
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Szeszenia-Dabrowska, Neonilia (author)
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Lissowska, Jolanta (author)
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Fabianova, Eleonora (author)
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Mates, Ioan Nicolae (author)
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Bencko, Vladimir (author)
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Foretova, Lenka (author)
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Janout, Vladimir (author)
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Curado, Maria Paula (author)
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Koifman, Sergio (author)
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Menezes, Ana (author)
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Wünsch-Filho, Victor (author)
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Eluf-Neto, José (author)
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Boffetta, Paolo (author)
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Garrote, Leticia Fernández (author)
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Serraino, Diego (author)
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Lener, Marcin (author)
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Jaworowska, Ewa (author)
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Lubiński, Jan (author)
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Boccia, Stefania (author)
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Rajkumar, Thangarajan (author)
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Samant, Tanuja A (author)
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Mahimkar, Manoj B (author)
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Matsuo, Keitaro (author)
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Franceschi, Silvia (author)
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Byrnes, Graham (author)
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Brennan, Paul (author)
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McKay, James D (author)
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(creator_code:org_t)
- 2015-03-20
- 2015
- English.
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In: PLOS ONE. - : Public library science. - 1932-6203. ; 10:3
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https://doi.org/10.1...
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Delahaye-Sourdei ...
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Oliver, Javier
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Timofeeva, Maria ...
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Gaborieau, Valér ...
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Johansson, Matti ...
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Chabrier, Amélie
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show more...
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Wozniak, Magdale ...
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Brenner, Darren ...
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Vallée, Maxime P
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Anantharaman, De ...
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Lagiou, Pagona
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Holcátová, Ivana
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Richiardi, Loren ...
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Kjaerheim, Krist ...
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Agudo, Antonio
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Castellsagué, Xa ...
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Macfarlane, Tati ...
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Barzan, Luigi
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Canova, Cristina
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Thakker, Nalin S
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Conway, David I
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Znaor, Ariana
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Healy, Claire M
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Ahrens, Wolfgang
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Zaridze, David
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Szeszenia-Dabrow ...
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Lissowska, Jolan ...
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Fabianova, Eleon ...
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Mates, Ioan Nico ...
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Bencko, Vladimir
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Foretova, Lenka
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Janout, Vladimir
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Curado, Maria Pa ...
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Koifman, Sergio
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Menezes, Ana
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Wünsch-Filho, Vi ...
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Eluf-Neto, José
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Boffetta, Paolo
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Garrote, Leticia ...
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Serraino, Diego
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Lener, Marcin
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Jaworowska, Ewa
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Lubiński, Jan
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Boccia, Stefania
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Rajkumar, Thanga ...
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Samant, Tanuja A
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Mahimkar, Manoj ...
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Matsuo, Keitaro
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Franceschi, Silv ...
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Byrnes, Graham
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Brennan, Paul
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McKay, James D
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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PLOS ONE
- By the university
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Umeå University