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The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract

Delahaye-Sourdeix, Manon (author)
Oliver, Javier (author)
Timofeeva, Maria N (author)
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Gaborieau, Valérie (author)
Johansson, Mattias (author)
Genetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France
Chabrier, Amélie (author)
Wozniak, Magdalena B (author)
Brenner, Darren R (author)
Vallée, Maxime P (author)
Anantharaman, Devasena (author)
Lagiou, Pagona (author)
Holcátová, Ivana (author)
Richiardi, Lorenzo (author)
Kjaerheim, Kristina (author)
Agudo, Antonio (author)
Castellsagué, Xavier (author)
Macfarlane, Tatiana V (author)
Barzan, Luigi (author)
Canova, Cristina (author)
Thakker, Nalin S (author)
Conway, David I (author)
Znaor, Ariana (author)
Healy, Claire M (author)
Ahrens, Wolfgang (author)
Zaridze, David (author)
Szeszenia-Dabrowska, Neonilia (author)
Lissowska, Jolanta (author)
Fabianova, Eleonora (author)
Mates, Ioan Nicolae (author)
Bencko, Vladimir (author)
Foretova, Lenka (author)
Janout, Vladimir (author)
Curado, Maria Paula (author)
Koifman, Sergio (author)
Menezes, Ana (author)
Wünsch-Filho, Victor (author)
Eluf-Neto, José (author)
Boffetta, Paolo (author)
Garrote, Leticia Fernández (author)
Serraino, Diego (author)
Lener, Marcin (author)
Jaworowska, Ewa (author)
Lubiński, Jan (author)
Boccia, Stefania (author)
Rajkumar, Thangarajan (author)
Samant, Tanuja A (author)
Mahimkar, Manoj B (author)
Matsuo, Keitaro (author)
Franceschi, Silvia (author)
Byrnes, Graham (author)
Brennan, Paul (author)
McKay, James D (author)
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 (creator_code:org_t)
2015-03-20
2015
English.
In: PLOS ONE. - : Public library science. - 1932-6203. ; 10:3
Related links:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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