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Sökning: WFRF:(Ramqvist Torbjörn)

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  • Bersani, Cinzia, et al. (författare)
  • A model using concomitant markers for predicting outcome in human papillomavirus positive oropharyngeal cancer
  • 2017
  • Ingår i: Oral Oncology. - Elsevier. - 1368-8375 .- 1879-0593. ; 68, s. 53-59
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Objective: Head-neck cancer therapy has become intensified. With radiotherapy alone, 3-year disease-free survival (DFS) is 80% for HPV-positive TSCC/BOTSCC and better for patients with favorable characteristics, suggesting therapy could be tapered for some, decreasing side-effects. Therefore, we built a model to predict progression-free survival for patients with HPV-positive TSCC and BOTSCC. Material and methods: TSCC/BOTSCC patients treated curatively between 2000 and 2011, with HPV16 DNA/E7 mRNA positive tumors examined for CD8(+) TILs, HPV16 mRNA and HLA class I expression were included. Patients were split randomly 65/35 into training and validation sets, and LASSO regression was used to select a model in the training set, the performance of which was evaluated in the validation set. Results: 258 patients with HPV DNA/E7 mRNA positive tumors could be included, 168 and 90 patients in the respective sets. No treatment improved prognosis compared to radiotherapy alone. CD8(+) TIL counts and young age were the strongest predictors of survival, followed by T-stage &lt;3 and presence of HPV16 E2 mRNA. The model had an area under curve (AUC) of 76%. A model where the presence of three of four of these markers defined good prognosis captured 56% of non-relapsing patients with a positive predictive value of 98% in the validation set. Furthermore, the model identified 35% of our cohort that was over-treated and could safely have received de-escalated therapy. Conclusion: CD8(+) TIL counts, age, T-stage and E2 expression could predict progression-free survival, identifying patients eligible for randomized trials with milder treatment, potentially reducing side effects without worsening prognosis.</p>
  • Bersani, Cinzia, et al. (författare)
  • MicroRNA-155,-185 and-193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma
  • 2018
  • Ingår i: Oral Oncology. - Elsevier. - 1368-8375 .- 1879-0593. ; 82, s. 8-16
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Objective: Three-year disease-free survival (DFS) is 80% for human papillomavirus (HPV) positive tonsillar and base of tongue cancer (TSCC/BOTSCC) treated with radiotherapy alone, and today's intensified therapy does not improve prognosis. More markers are therefore needed to more accurately identify patients with good prognosis or in need of alternative therapy. Here, microRNAs (miRs) 155, 185 and 193b were examined as potential prognostic markers in TSCC/BOTSCC.</p><p>Material and methods: 168 TSCC/BOTSCC patients diagnosed 2000-2013, with known data on HPV-status, CD8(+) tumour infiltrating lymphocytes, tumour staging and survival were examined for expression of miR-155, -185 and -193b using Real-Time PCR. Associations between miR expression and patient and tumour characteristics were analysed using univariate testing and multivariate regression.</p><p>Results: Tumours compared to normal tonsils showed decreased miR-155 and increased miR-193b expression. miR-155 expression was associated with HPV-positivity, low T-stage, high CD8(+) TIL counts and improved survival. miR-185 expression was associated with HPV-negativity and a tendency towards decreased survival, while miR-193b expression was associated with higher T-stage, male gender and lower CD8(+) TIL counts, but not with outcome. Upon Cox regression, miR-185 was the only miR significantly associated with survival. Combining miR-155 and miR-185 to predict outcome in HPV+ patients yielded an area under curve (AUC) of 71%.</p><p>Conclusion: Increased miR-155 expression was found as a positive predictor of survival, with the effect mainly due to its association with high CD8(+) TIL numbers, while miR-185 independently associated with decreased survival. Addition of these miRs to previously validated prognostic biomarkers could improve patient stratification accuracy.</p>
  • Dahlstrand, Hanna, et al. (författare)
  • Human papillomavirus accounts both for increased incidence and better prognosis in tonsillar cancer.
  • 2008
  • Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 28:2B, s. 1133-8
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The aim of this review is to present the current knowledge on the status and significance of human papillomavirus (HPV) in tonsillar cancer. An increase in the incidence of tonsillar cancer has been reported and recent data suggest that this increase is due to an increased proportion of HPV in these tumours. Furthermore, patients with HPV positive cancer have been shown to have a lower risk of relapse and longer survival compared to patients with HPV-negative tonsillar cancer. Tailoring individual treatment in tonsillar cancer may be of importance in order to reduce patient suffering as well as to increase patient survival. Finally, the fact that the presence of HPV-type 16 E6 and E7 mRNA has been ascertained in tonsillar cancer suggests that HPV-16 indeed is an aetiological factor associated with the disease and that preventive vaccination for this patient group should be discussed.</p>
  • Du, Juan, et al. (författare)
  • Prevalence of Oral Human Papillomavirus Infection among Youth, Sweden
  • 2012
  • Ingår i: Emerging Infectious Diseases. - Centers for Disease Control and Prevention. - 1080-6040 .- 1080-6059. ; 18:9, s. 1468-1471
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Human papillomavirus (HPV) causes cervical, head, and neck cancers. We studied 483 patients at a youth clinic in Stockholm, Sweden, and found oral HPV prevalence was 9.3% and significantly higher for female youth with than without cervical HPV infection (p = 0.043). Most oral HPV types matched the co-occurring cervical types.</p>
  • Eriksson, Mathilda, et al. (författare)
  • Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin
  • 2009
  • Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 29:1, s. 11-18
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>BACKGROUND:</strong></p> <p>The nano-sized right-handed coiled-coil (RHCC) protein, originating from the archaebacterium Staphylothermus marinus, is stable at high salt concentrations, high temperatures, high pressures and extremes of pH. Its crystal structure reveals four hydrophobic cavities which can incorporate heavy metals. Nano-sized compounds have been used to carry cytotoxic drugs to tumours, avoiding delivery to healthy tissue, in part due to enhanced permeability in tumour blood vessels (enhanced permeability and retention effect).</p> <p><strong>MATERIALS AND METHODS:</strong></p> <p>The ability of RHCC to carry the platinum-containing chemotherapeutic drug cisplatin to cells, while retaining the cytotoxic potential was tested both in vitro and in vivo.</p> <p><strong>RESULTS:</strong></p> <p>RHCC was able to bind and enter cells in vitro and was not severely toxic or immunogenic in mice. Moreover, RHCC incorporated cisplatin, without inhibiting the cytotoxic potential of the drug against tumour cell lines in vitro or in vivo.</p> <p><strong>CONCLUSION:</strong></p> <p>RHCC can be used as a carrier of cisplatin without abrogating the effect of the drug.</p>
  • Grün, Nathalie, et al. (författare)
  • Human papillomavirus prevalence in mouthwashes of patients undergoing tonsillectomy shows dominance of HPV69, without the corresponding finding in the tonsils.
  • 2017
  • Ingår i: Infectious diseases (London, England). - 2374-4243. ; 49:8, s. 588-593
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>BACKGROUND:</strong> The role of human papillomavirus (HPV) in tonsillar squamous cell carcinomas (TSCC) is of interest, since a considerable proportion of TSCC in Sweden and other Western countries is HPV positive. Nevertheless, the natural history of HPV in normal tonsils, and the progression from localized infection to pre-malignant lesion to cancer are poorly understood. The aim of this study was to investigate whether HPV types found in mouthwash samples correlated to those in tonsillar tissue from the same individuals undergoing tonsillectomy.</p><p><strong>METHODS:</strong> Mouthwash samples from 232 patients, aged 3-56 years, undergoing tonsillectomy, the majority with chronic tonsillitis, were collected at the time of surgery and analysed for the presence of 27 HPV types by a bead based multiplex assay.</p><p><strong>RESULTS:</strong> An HPV prevalence of 10.3% (24/232) was observed in mouthwash samples, with HPV 69 being the dominant type (10/24). Ten patients were positive for high risk HPV (HPV 16, 33, 35, 45, 56, 59). None of the tonsils resected from patients with HPV-positive mouthwash samples were positive for HPV.</p><p><strong>CONCLUSIONS:</strong> Despite an oral HPV prevalence of 10.3% in mouthwash samples from tonsillectomized patients, with dominance of HPV 69, none of the corresponding tonsillar samples exhibited the presence of HPV.</p>
  • Josefsson, Torbjörn, et al. (författare)
  • The history of early cereal cultivation in northernmost Fennoscandia as indicated by palynological research
  • 2014
  • Ingår i: Vegetation History and Archaeobotany. - Springer-Verlag New York. - 0939-6314 .- 1617-6278. ; 23:6, s. 821-840
  • Forskningsöversikt (refereegranskat)abstract
    • <p>The age of the introduction of cereal cultivation in northern Europe has long been debated by researchers from many disciplines, in particular archaeology and palaeoecology. Over the past 40 years extensive palynological data have been collected concerning pre-industrial land use in northern Fennoscandia. This paper reviews palynological studies that include records of fossil cereal pollen from northernmost Sweden, Finland and Norway at latitudes north of 63A degrees N. The geographical extent of known early cultivation sites is constantly expanding, with more than 100 records of cereal pollen pre-dating ad 1700. The oldest records of scattered cereal pollen derive from Neolithic times. Periods of continuous cultivation, indicated by cereal pollen recorded recurrently in the sediment profiles, derive from the Late Neolithic and Early Bronze Age. Collectively, the reviewed pollen records indicate that cereal cultivation was first introduced into areas close to the coast and later to the interior, and that it may have been practiced locally long before sedentary settlements based on intensive cultivation were established during medieval times. The data do not indicate a latitudinal spread of cultivation from south to north. However, methodological problems relating to pollen morphology of cereals, site characteristics and lack of connections to archaeologically excavated sites imply that the value of many early cereal pollen finds remains unclear. To increase our understanding of the context in which cereal cultivation was introduced in northernmost Fennoscandia, multidisciplinary studies integrating palaeoecology, archaeology and history are needed.</p>
  • Lindquist, David, et al. (författare)
  • Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7.
  • 2007
  • Ingår i: Molecular oncology. - 1878-0261. ; 1:3, s. 350-5
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>From 1970 to 2002 in the Stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases, indicating a possible role of HPV infection in this disease. We have now examined whether HPV and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of HPV-16 E6 and E7 mRNA could be ascertained. The presence of HPV-16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome. Moreover, E6 and/or E7 were expressed in almost all assessable HPV-16 positive cases, supporting an oncogenic role of HPV-16 in tonsillar cancer.</p>
  • Nordfors, Cecilia, et al. (författare)
  • Oral human papillomavirus prevalence in high school students of one municipality in Sweden
  • 2013
  • Ingår i: Scandinavian Journal of Infectious Diseases. - 0036-5548 .- 1651-1980. ; 45:11, s. 878-881
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The rise in human papillomavirus (HPV) infection has been suggested to be responsible for the increased incidence of oropharyngeal cancer in the Western world. This has boosted interest in oral HPV prevalence and whether HPV vaccines can prevent oral HPV infection. In a previous study we showed oral HPV prevalenceto be almost 10% in youth aged 15-23 y attending a youth clinic in Stockholm, Sweden. However, this may not be a generalizable sample within the Swedish population. Therefore, mouthwashes were used to investigate oral HPV prevalence in 335 Swedish high school students aged 17-21 y (median age 18 y), from 1municipality with 140,000 inhabitants. The presence of HPV DNA in the oral samples, as examined by a Luminex-based assay, was significantly lower in this cohort, only 1.8% (3.1% in females and 0.6% in males), as compared to our previous study.</p>
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