| 1. |
- Amen, Rafael, et al.
(författare)
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Matching Design Tasks To Knowledge Based Software Tools
- 1999
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Ingår i: Proceedings of the 1999 ASME Design Engineering Technical Conferences.. - New York : American Society of Mechanical Engineers.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Ek, Weronica E., et al.
(författare)
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Tea and coffee consumption in relation to DNA methylation in four European cohorts
- 2017
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 26:16, s. 3221-3231
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Tidskriftsartikel (refereegranskat)abstract
- Lifestyle factors, such as food choices and exposure to chemicals, can alter DNA methylation and lead to changes in gene activity. Two such exposures with pharmacologically active components are coffee and tea consumption. Both coffee and tea has been suggested to play an important role in modulating disease-risk in humans by suppressing tumour progression, decreasing inflammation and influencing estrogen metabolism. These mechanisms may be mediated by changes in DNA methylation.To investigate if DNA methylation in blood is associated with coffee and tea consumption we performed a genome-wide DNA methylation study for coffee and tea consumption in four European cohorts (N = 3,096). DNA methylation was measured from whole blood at 421,695 CpG sites distributed throughout the genome and analysed in men and women both separately and together in each cohort. Meta-analyses of the results and additional regional-level analyses were performed.After adjusting for multiple testing, the meta-analysis revealed that two individual CpG-sites, mapping to DNAJC16 and TTC17, were differentially methylated in relation to tea consumption in women. No individual sites were associated in men or in the sex-combined analysis for tea or coffee. The regional analysis revealed that 28 regions were differentially methylated in relation to tea consumption in women. These regions contained genes known to interact with estradiol metabolism and cancer. No significant regions were found in the sex-combined and male-only analysis for either tea or coffee consumption.
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| 4. |
- Ran, Heng, 1981, et al.
(författare)
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Damaged Ro-Pax Vessel Time to Capsize
- 2012
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Ingår i: Proceedings of the 11th International Conference on the Stability of Ships and Ocean Waves. - 9786188016309 ; , s. 373-379
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Konferensbidrag (refereegranskat)abstract
- The time for a RoPax vessel (M.S. Estonia) to capsize after a hull breach event is investigated with both physical model experiments and computer based time domai simulations. A two compartment side damage is modelled and a series of tests at stationary head wind/wave is performed. A parabolic inflow velocity model is developed to simulate water ingression through the damaged opening. A two dimensional multi-model sloshing model, composed by a non-linear pendulum model near resonance and an acceleration ratio model at non-resonance, is used for calculating ingressed water transverse center of gravity in the damaged compartment and on car deck.
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| 10. |
- Sunnersjö, Staffan, et al.
(författare)
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A Transparent Design System for Iterative Product Development
- 2006
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Ingår i: Journal of Computing and Information Science in Engineering. - : ASME International. - 1530-9827 .- 1944-7078. ; 6:3, s. 300-307
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Tidskriftsartikel (refereegranskat)abstract
- Automated systems for variant design can be used for design iterations in order to guide the designer towards solutions that are optimized with respect to weight, cost, lead time, or other vital properties. In this work such a system for computational design problems is presented together with examples of its application. The system performs design computations, computed aided design model configuration, production process planning, and cost estimation. The design rules and algorithms are captured in knowledge "chunks," which are human readable as well as computer executable. The workflow governing the execution of these rules and algorithms is created using a dependency structure matrix (DSM) which is included in the system. Particular attention has been given to the need for transparency, modularity, and longevity of the system, which is a prerequisite for such a system to become a viable tool in industrial applications. Experiences from the proposed system indicate that the DSM workflow manager in combination with a human readable and modularized knowledge base provides clarity and transparency for both developer and user of the system.
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