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Long-Term Effects o...
Long-Term Effects of Oxygen Therapy on Death or Hospitalization for Heart Failure in Patients With Suspected Acute Myocardial Infarction
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- Jernberg, T. (författare)
- Karolinska Institute,Danderyd Hospital
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- Lindahl, B. (författare)
- Uppsala University
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- Alfredsson, J. (författare)
- Linköping University
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- Berglund, E. (författare)
- Karolinska Institute
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- Bergstrom, O. (författare)
- Växjö Central Hospital
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- Engstrom, A. (författare)
- Kalmar County Hospital
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups
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- Herlitz, Johan, 1949 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital
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- Jumatate, Raluca (författare)
- Central Hospital Kristianstad
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- Kellerth, T. (författare)
- Örebro University Hospital
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- Lauermann, J. (författare)
- Ryhov County Hospital, Jönköping
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- Lindmark, K. (författare)
- Umeå University
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- Lingman, Markus, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Halmstad County Hospital
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- Ljung, L. (författare)
- Karolinska Institute,Stockholm South General Hospital
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- Nilsson, C. (författare)
- Ljungby lasarett
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- Omerovic, Elmir, 1968 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital
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- Pernow, J. (författare)
- Karolinska Institute,Karolinska University Hospital
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- Ravn-Fischer, Annica, 1974 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital
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- Sparv, David (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Yndigegn, Troels (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ostlund, O. (författare)
- Uppsala University
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- James, S. K. (författare)
- Uppsala University
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- Hofmann, R. (författare)
- Karolinska Institute
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2018
- 2018
- Engelska.
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Ingår i: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 0009-7322 .- 1524-4539. ; 138:24, s. 2754-2762
- Relaterad länk:
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https://www.ahajourn...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: In the DETO2X-AMI trial (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air in normoxemic patients presenting with suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report the prespecified secondary end points cardiovascular death and the composite of all-cause death and hospitalization for heart failure. METHODS: In this pragmatic, registry-based randomized clinical trial, we used a nationwide quality registry for coronary care for trial procedures and evaluated end points through the Swedish population registry (mortality), the Swedish inpatient registry (heart failure), and cause of death registry (cardiovascular death). Patients with suspected acute myocardial infarction and oxygen saturation of >= 90% were randomly assigned to receive either supplemental oxygen at 6 L/min for 6 to 12 hours delivered by open face mask or ambient air. RESULTS: A total of 6629 patients were enrolled. Acute heart failure treatment, left ventricular systolic function assessed by echocardiography, and infarct size measured by high-sensitive cardiac troponin T were similar in the 2 groups during the hospitalization period. All-cause death or hospitalization for heart failure within 1 year after randomization occurred in 8.0% of patients assigned to oxygen and in 7.9% of patients assigned to ambient air (hazard ratio, 0.99; 95% CI, 0.84-1.18; P=0.92). During long-term follow-up (median [range], 2.1 [1.0-3.7] years), the composite end point occurred in 11.2% of patients assigned to oxygen and in 10.8% of patients assigned to ambient air (hazard ratio, 1.02; 95% CI, 0.88-1.17; P=0.84), and cardiovascular death occurred in 5.2% of patients assigned to oxygen and in 4.8% assigned to ambient air (hazard ratio, 1.07; 95% CI, 0.87-1.33; P=0.52). The results were consistent across all predefined subgroups. CONCLUSIONS: Routine use of supplemental oxygen in normoxemic patients with suspected myocardial infarction was not found to reduce the composite of all-cause mortality and hospitalization for heart failure, or cardiovascular death within 1 year or during long-term follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- death
- heart failure
- hospitalization
- mortality
- myocardial infarction
- oxygen inhalation therapy
- intensive statin therapy
- acute coronary syndromes
- st-segment-elevation
- task-force
- management
- disease
- size
- supplementation
- inhalation
- guideline
- registries
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Jernberg, T.
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Lindahl, B.
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Alfredsson, J.
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Berglund, E.
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Bergstrom, O.
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Engstrom, A.
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visa fler...
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Erlinge, David
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Herlitz, Johan, ...
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Jumatate, Raluca
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Kellerth, T.
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Lauermann, J.
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Lindmark, K.
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Lingman, Markus, ...
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Ljung, L.
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Nilsson, C.
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Omerovic, Elmir, ...
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Pernow, J.
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Ravn-Fischer, An ...
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Sparv, David
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Yndigegn, Troels
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Ostlund, O.
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James, S. K.
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Hofmann, R.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Circulation
- Av lärosätet
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Göteborgs universitet
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Lunds universitet