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Up-Front Autologous...
Up-Front Autologous Stem-Cell Transplantation in Peripheral T-Cell Lymphoma : NLG-T-01
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d'Amore, Francesco (author)
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- Relander, Thomas (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Lauritzsen, Grete F. (author)
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Jantunen, Esa (author)
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- Hagberg, Hans (author)
- Uppsala universitet,Enheten för onkologi
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- Anderson, Harald (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Holte, Harald (author)
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- Osterborg, Anders (author)
- Karolinska Institutet
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Merup, Mats (author)
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Brown, Peter (author)
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Kuittinen, Outi (author)
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- Erlanson, Martin (author)
- Umeå universitet,Onkologi
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Ostenstad, Bjorn (author)
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Fagerli, Unn-Merete (author)
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Gadeberg, Ole V. (author)
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- Sundström, Christer (author)
- Uppsala universitet,Molekylär och morfologisk patologi,alafuzoff
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Delabie, Jan (author)
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Ralfkiaer, Elisabeth (author)
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Vornanen, Martine (author)
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Toldbod, Helle E. (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:25, s. 3093-3099
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Abstract
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- Purpose Systemic peripheral T-cell lymphomas (PTCLs) respond poorly to conventional therapy. To evaluate the efficacy of a dose-dense approach consolidated by up-front high-dose chemotherapy (HDT) and autologous stem-cell transplantation (ASCT) in PTCL, the Nordic Lymphoma Group (NLG) conducted a large prospective phase II study in untreated systemic PTCL. This is the final report, with a 5-year median follow-up, of the NLG-T-01 study. Patients and Methods Treatment-naive patients with PTCL age 18 to 67 years (median, 57 years) were included. Anaplastic lymphoma kinase (ALK) -positive anaplastic large-cell lymphoma (ALCL) was excluded. An induction regimen of six cycles of biweekly CHOEP (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone) was administered (in patients age > 60 years, etoposide was omitted). If in complete or partial remission, patients proceeded to consolidation with HDT/ASCT. Results Of 166 enrolled patients, 160 had histopathologically confirmed PTCL. The majority presented with advanced-stage disease, B symptoms, and elevated serum lactate dehydrogenase. A total of 115 underwent HDT/ASCT, with 90 in complete remission at 3 months post-transplantation. Early failures occurred in 26%. Treatment-related mortality was 4%. At 60.5 months of median follow-up, 83 patients were alive. Consolidated 5-year overall and progression-free survival (PFS) were 51% (95% CI, 43% to 59%) and 44% (95% CI, 36% to 52%), respectively. Best results were obtained in ALK-negative ALCL. Conclusion Dose-dense induction followed by HDT/ASCT was well tolerated and led to long-term PFS in 44% of treatment-naive patients with PTCL. This represents an encouraging outcome, particularly considering the high median age and adverse risk profile of the study population. Therefore, dose-dense induction and HDT/ASCT are a rational up-front strategy in transplantation-eligible patients with PTCL. J Clin Oncol 30: 3093-3099. (C) 2012 by American Society of Clinical Oncology
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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d'Amore, Frances ...
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Relander, Thomas
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Lauritzsen, Gret ...
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Jantunen, Esa
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Hagberg, Hans
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Anderson, Harald
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show more...
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Holte, Harald
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Osterborg, Ander ...
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Merup, Mats
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Brown, Peter
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Kuittinen, Outi
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Erlanson, Martin
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Ostenstad, Bjorn
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Fagerli, Unn-Mer ...
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Gadeberg, Ole V.
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Sundström, Chris ...
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Delabie, Jan
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Ralfkiaer, Elisa ...
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Vornanen, Martin ...
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Toldbod, Helle E ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Journal of Clini ...
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Uppsala University
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Lund University
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Karolinska Institutet
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Umeå University