- Resic-Lindehammar, Sabina, et al.
Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
Ingår i: Acta Diabetologica. - Springer Milan. - 0940-5429 .- 1432-5233. ; 45:4, s. 231-235
- <p>The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1–18-year-old patients with type 1 diabetes newly diagnosed in 1986–1987 (<em>n</em> = 430), 1996–2000 (<em>n</em> = 342) and in 2003–2005 (<em>n</em> = 171). We tested the hypothesis that the <em>HLA DQ</em> genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for <em>DQ A1</em>* and <em>B1</em>* alleles. The most common type 1 diabetes HLA <em>DQA1*-B1*</em>genotype <em>0501-0201/0301-0302</em> was 36% (153/430) in 1986–1987 and 37% (127/342) in 1996–2000, but decreased to 19% (33/171) in 2003–2005 (<em>P</em> < 0.0001). The <em>0501-0201/0501-0201</em> genotype increased from 1% in 1986–1987 to 7% in 1996–2000 (<em>P</em> = 0.0047) and to 5% in 2003–2005 (<em>P</em> > 0.05). This study in 1–18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.</p>