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Sökning: WFRF:(Reszka E)

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  • Reszka, E, et al. (författare)
  • Epigenetic Changes in Neoplastic Mast Cells and Potential Impact in Mastocytosis
  • 2021
  • Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 22:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Systemic mastocytosis (SM) is a hematologic neoplasm with abnormal accumulation of mast cells in various organ systems such as the bone marrow, other visceral organs and skin. So far, only little is known about epigenetic changes contributing to the pathogenesis of SM. In the current article, we provide an overview of epigenetic changes that may occur and be relevant to mastocytosis, including mutations in genes involved in epigenetic processes, such as TET2, DNMT3A and ASXL1, and global and gene-specific methylation patterns in neoplastic cells. Moreover, we discuss methylation-specific pathways and other epigenetic events that may trigger disease progression in mast cell neoplasms. Finally, we discuss epigenetic targets and the effects of epigenetic drugs, such as demethylating agents and BET-targeting drugs, on growth and viability of neoplastic mast cells. The definitive impact of these targets and the efficacy of epigenetic therapies in advanced SM need to be explored in future preclinical studies and clinical trials.
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  • Sadowski, Janusz, et al. (författare)
  • GaAs-MnAs nanowires
  • 2011
  • Ingår i: Physica Status Solidi. B: Basic Research. - : Wiley. - 0370-1972. ; 248:7, s. 1576-1580
  • Tidskriftsartikel (refereegranskat)abstract
    • Different strategies for obtaining nanowires (NWs) with ferromagnetic properties using the molecular beam epitaxy (MBE) grown nanostructures combining GaAs and Mn were investigated. Four types of structures have been studied: (i) self-catalyzed GaAs: Mn NWs grown at low temperatures on GaAs(100) substrates; (ii) GaAs: Mn NWs grown at high temperatures on Si(100) substrates; (iii) GaAs-GaMnAs core-shell NW structures; (iv) GaAs-MnAs core-shell NW structures grown on Si(100). Structures of types (i), (iii), and (iv) exhibit ferromagnetic properties. Right: Scanning electron microscopy image of Mn doped GaAs NWs with Ga droplets at the tops, grown by MBE on oxidized Si(100) substrate in the autocatalytic growth mode. (C) 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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  • Resultat 1-6 av 6

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